Michael Sternberg

Last updated

Mike Sternberg
Born
Michael Joseph Ezra Sternberg

(1951-06-24) 24 June 1951 (age 72) [1]
Alma mater
Awards
Scientific career
Fields
Institutions
Thesis Studies of Protein Conformation  (1977)
Doctoral advisor David Chilton Phillips [3]
Website www.imperial.ac.uk/people/m.sternberg

Michael Joseph Ezra Sternberg (born 24 June 1951) [1] is a professor at Imperial College London, where he is director of the Centre for Integrative Systems Biology and Bioinformatics [4] and Head of the Structural bioinformatics Group. [2] [5] [6] [7]

Contents

Education

Sternberg was educated at Hendon County Grammar School and Gonville and Caius College, Cambridge, where he was awarded a Bachelor of Arts degree in natural sciences (theoretical physics) in 1972. [1] He went on to do a Master of Science degree in Computing at Imperial College London followed by a DPhil degree from the University of Oxford (Wolfson College, Oxford) in 1978 for research supervised by David Chilton Phillips. [3] [8] [9] [10] [11] [12]

Career

After postdoctoral research at the University of Oxford, Sternberg became a Lecturer in the Department of Crystallography at Birkbeck College, London. He went on to work at the Imperial Cancer Research Fund and joined Imperial College in 2001. [1] [13] [14] [15] [16] He is the Director of the Centre for Integrative Systems Biology and Bioinformatics [4] at Imperial College.

Research

Sternberg's research interests are in protein structure prediction, protein function prediction, prediction of macromolecular docking and interactions, network modelling for systems biology and logic-based drug design. [13] [17] [18] [19] [20] [21] [22] [23] [24] [25]

He has authored or co-authored several books including From Cells to Atoms: an illustrated introduction to molecular biology, [26] Protein Engineering: a practical approach [27] and Protein Structure Prediction: a practical approach. [28]

During his DPhil research at Oxford he worked with Janet Thornton and they undertook some of the first systematic analyses of protein structure. They identified that the beta-alpha-beta unit in proteins is nearly always right handed and this explained remarkable similarities between protein structures.[ citation needed ]

His group, particularly Lawrence Kelley, have developed the widely used Phyre/Phyre2 web server [29] [30] [31] for protein structure prediction. This web resource has been used by over 100,000 distinct users worldwide.[ citation needed ]

Recently his PhD student Chris Yates developed SuSPect, [32] a novel powerful method to predict the phenotypic effects of Single-nucleotide polymorphisms and other amino acid variants.

Awards and honours

Sternberg was elected a Fellow of the Royal Society of Biology (FRSB) and a Fellow of the Institute of Biology (FIBiol). He is an associate editor of the Journal of Molecular Biology .

Related Research Articles

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References

  1. 1 2 3 4 "STERNBERG, Prof. Michael Joseph Ezra" . Who's Who . Vol. 2014 (online Oxford University Press  ed.). A & C Black.(Subscription or UK public library membership required.)
  2. 1 2 Michael Sternberg publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  3. 1 2 Sternberg, Michael Joseph Ezra (1977). Studies of protein conformation (DPhil thesis). University of Oxford.
  4. 1 2 "Imperial College London".
  5. ↑ Michael Sternberg's publications indexed by the Scopus bibliographic database. (subscription required)
  6. ↑ Michael J. E. Sternberg at DBLP Bibliography Server OOjs UI icon edit-ltr-progressive.svg
  7. ↑ Michael Sternberg publications indexed by Microsoft Academic
  8. ↑ Cohen, F. E.; Sternberg, M. J.; Phillips, D. C.; Kuntz, I. D.; Kollman, P. A. (1980). "A diffusion--collision--adhesion model for the kinetics of myoglobin refolding". Nature. 286 (5773): 632–4. Bibcode:1980Natur.286..632C. doi:10.1038/286632a0. PMID   7402344. S2CID   4348559.
  9. ↑ Artymiuk, P. J.; Blake, C. C.; Grace, D. E.; Oatley, S. J.; Phillips, D. C.; Sternberg, M. J. (1979). "Crystallographic studies of the dynamic properties of lysozyme". Nature. 280 (5723): 563–8. Bibcode:1979Natur.280..563A. doi:10.1038/280563a0. PMID   460438. S2CID   32299121.
  10. ↑ Sternberg, M. J.; Grace, D. E.; Phillips, D. C. (1979). "Dynamic information from protein crystallography. An analysis of temperature factors from refinement of the hen egg-white lysozyme structure". Journal of Molecular Biology. 130 (3): 231–52. doi:10.1016/0022-2836(79)90539-4. PMID   469942.
  11. ↑ Phillips, D. C.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1978). "An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenase". Journal of Molecular Biology. 119 (2): 329–51. doi:10.1016/0022-2836(78)90440-0. PMID   633372.
  12. ↑ Phillips, D. C.; Rivers, P. S.; Sternberg, M. J.; Thornton, J. M.; Wilson, I. A. (1977). "An analysis of the three-dimensional structure of chicken triose phosphate isomerase". Biochemical Society Transactions. 5 (3): 642–7. doi:10.1042/bst0050642. PMID   902882.
  13. 1 2 Michael Sternberg, Imperial College London
  14. ↑ Sternberg, M. J.; Thornton, J. M. (1978). "Prediction of protein structure from amino acid sequence". Biochemical Society Transactions. 6 (6): 1119–23. doi:10.1042/bst0061119. PMID   744369.
  15. ↑ Sternberg, M. J.; Thornton, J. M. (1978). "Prediction of protein structure from amino acid sequence". Nature. 271 (5640): 15–20. Bibcode:1978Natur.271...15S. doi:10.1038/271015a0. PMID   342964. S2CID   4160357.
  16. ↑ Blundell, T. L.; Sibanda, B. L.; Sternberg, M. J.; Thornton, J. M. (1987). "Knowledge-based prediction of protein structures and the design of novel molecules". Nature. 326 (6111): 347–52. Bibcode:1987Natur.326..347B. doi:10.1038/326347a0. PMID   3550471. S2CID   4330510.
  17. ↑ Wass, M. N.; Barton, G.; Sternberg, M. J. E. (2012). "Comb Func: Predicting protein function using heterogeneous data sources". Nucleic Acids Research. 40 (Web Server issue): W466–W470. doi:10.1093/nar/gks489. PMC   3394346 . PMID   22641853.
  18. ↑ Kelley, L. A.; MacCallum, R. M.; Sternberg, M. J. E. (2000). "Enhanced genome annotation using structural profiles in the program 3D-PSSM". Journal of Molecular Biology. 299 (2): 501–522. doi:10.1006/jmbi.2000.3741. PMID   10860755.
  19. ↑ Gabb, H. A.; Jackson, R. M.; Sternberg, M. J. E. (1997). "Modelling protein docking using shape complementarity, electrostatics and biochemical information". Journal of Molecular Biology. 272 (1): 106–20. doi:10.1006/jmbi.1997.1203. PMID   9299341.
  20. ↑ Barton, G. J.; Sternberg, M. J. (1987). "A strategy for the rapid multiple alignment of protein sequences. Confidence levels from tertiary structure comparisons". Journal of Molecular Biology. 198 (2): 327–37. doi:10.1016/0022-2836(87)90316-0. PMID   3430611.
  21. ↑ Zvelebil, M. J.; Barton, G. J.; Taylor, W. R.; Sternberg, M. J. (1987). "Prediction of protein secondary structure and active sites using the alignment of homologous sequences". Journal of Molecular Biology. 195 (4): 957–61. doi:10.1016/0022-2836(87)90501-8. PMID   3656439.
  22. ↑ King, R. D.; Sternberg, M. J. E. (1996). "Identification and application of the concepts important for accurate and reliable protein secondary structure prediction". Protein Science. 5 (11): 2298–2310. doi:10.1002/pro.5560051116. PMC   2143286 . PMID   8931148.
  23. ↑ Lewis, T. E.; Sillitoe, I; Andreeva, A; Blundell, T. L.; Buchan, D. W.; Chothia, C; Cozzetto, D; Dana, J. M.; Filippis, I; Gough, J; Jones, D. T.; Kelley, L. A.; Kleywegt, G. J.; Minneci, F; Mistry, J; Murzin, A. G.; Ochoa-Montaño, B; Oates, M. E.; Punta, M; Rackham, O. J.; Stahlhacke, J; Sternberg, M. J.; Velankar, S; Orengo, C (2015). "Genome3D: Exploiting structure to help users understand their sequences". Nucleic Acids Research. 43 (Database issue): D382–6. doi:10.1093/nar/gku973. PMC   4384030 . PMID   25348407.
  24. ↑ Radivojac, P.; Clark, W. T.; Oron, T. R.; Schnoes, A. M.; Wittkop, T.; Sokolov, A.; Graim, K.; Funk, C.; Verspoor, K.; Ben-Hur, A.; Pandey, G.; Yunes, J. M.; Talwalkar, A. S.; Repo, S.; Souza, M. L.; Piovesan, D.; Casadio, R.; Wang, Z.; Cheng, J.; Fang, H.; Gough, J.; Koskinen, P.; Törönen, P.; Nokso-Koivisto, J.; Holm, L.; Cozzetto, D.; Buchan, D. W. A.; Bryson, K.; Jones, D. T.; et al. (2013). "A large-scale evaluation of computational protein function prediction". Nature Methods. 10 (3): 221–227. doi:10.1038/nmeth.2340. PMC   3584181 . PMID   23353650.
  25. ↑ Lewis, T. E.; Sillitoe, I; Andreeva, A; Blundell, T. L.; Buchan, D. W.; Chothia, C; Cuff, A; Dana, J. M.; Filippis, I; Gough, J; Hunter, S; Jones, D. T.; Kelley, L. A.; Kleywegt, G. J.; Minneci, F; Mitchell, A; Murzin, A. G.; Ochoa-Montaño, B; Rackham, O. J.; Smith, J; Sternberg, M. J.; Velankar, S; Yeats, C; Orengo, C (2013). "Genome3D: A UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains". Nucleic Acids Research. 41 (Database issue): D499–507. doi:10.1093/nar/gks1266. PMC   3531217 . PMID   23203986.
  26. ↑ From Cells to Atoms: an illustrated introduction to molecular biology ISBN   0632008881
  27. ↑ Protein Engineering: a practical approach ISBN   0199631387
  28. ↑ Protein Structure Prediction: a practical approach ISBN   0199634963|
  29. ↑ Kelley, L. A.; Sternberg, M. J. E. (2009). "Protein structure prediction on the Web: A case study using the Phyre server". Nature Protocols. 4 (3): 363–71. doi:10.1038/nprot.2009.2. hdl: 10044/1/18157 . PMID   19247286. S2CID   12497300.
  30. ↑ Bennett-Lovsey, R. M.; Herbert, A. D.; Sternberg, M. J. E.; Kelley, L. A. (2007). "Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre". Proteins: Structure, Function, and Bioinformatics. 70 (3): 611–625. doi:10.1002/prot.21688. PMID   17876813. S2CID   23530683.
  31. ↑ "Redirecting to Phyre2".
  32. ↑ Yates, C. M.; Filippis, I; Kelley, L. A.; Sternberg, M. J. (2014). "SuSPect: Enhanced prediction of single amino acid variant (SAV) phenotype using network features". Journal of Molecular Biology. 426 (14): 2692–701. doi:10.1016/j.jmb.2014.04.026. PMC   4087249 . PMID   24810707.
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