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Michel Kahaleh is an American gastroenterologist and an expert in therapeutic endoscopy.
He is a Professor of Medicine, and is currently the Clinical Director of Gastroenterology, Chief of Endoscopy, and Director of the Pancreas Program at the Department of Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey. [1] He is the Founder and Director of the Therapeutic Endoscopic Ultrasound Society. [2] He is the Founder and CEO of the non-profit organization Innovative Digestive Health Education & Research Inc. (IDHER) since 2018 [3] He is also the Founder and CEO of the non-profit organization Foundation for Interventional and Therapeutic Endoscopy (FITE) since 2020 [4]
Trained in Erasme Hospital, University of Brussels by Michel Cremer and Jacques Deviere, he became the leader of the Pancreatico-Biliary group at the University of Virginia before joining Weill Cornell Medical College as the Chief of Endoscopy and Pancreas Program Director in July 2011. In January 2018, Kahaleh joined Rutgers Robert Wood Johnson University as clinical director of gastroenterology and chief of endoscopy. Kahaleh's research is focused on interventional endoscopy, and the use of new devices to diagnose and treat various gastrointestinal disorders.
Kahaleh has conducted 30 clinical research studies [5] since 15 years and published 320 papers [6] and 200 national and international scientific presentations. [7]
Kahaleh has been involved in in-vivo projects aiming at improving minimally invasive procedures such as per-oral endoscopic myotomy (POEM) [8] [9] for achalasia, [10] gallbladder drainage, [11] biliary [12] and pancreatic [13] [14] decompression. He is credited with creating a new endoscopic approach for biliary obstructions in altered anatomy patients called EUS-directed transgastric endoscopic retrograde cholangiopancreatography (EDGE). [15] [16] [17]
He helped develop and validate new diagnostic criteria for improving accuracy in diagnosis of bile duct cancer using confocal laser endomicroscopy [18] [19] [20] [21] called the Paris classification. [22] [23] He led a team of expert endoscopists to develop and validate the Monaco classification [24] diagnostic criteria for bile duct cancer using the SpyGlass® Direct Visualization System for cholangioscopy.
Kahaleh was one of the first to publish on radio frequency ablation (RFA) for bile duct cancer and pancreatic cancer therapy using Nagy Habib's probe in the United States. He was the first to publish a clinical trial on photodynamic therapy (PDT) in the United States for bile duct cancer. [25] [26] He was the first to conduct a pre-clinical study of a radio frequency ablation probe using endoscopic ultrasound (EUS-RFA) meant for treating pancreatic cancer. [27] The EUS-RFA probe was created by Nagy Habib and has been successfully used in humans after the pre-clinical study. [28]
Kahaleh has further published papers on additional minimally invasive endoscopic treatment for several conditions including pancreatic fluid collections, [29] gastroparesis, [30] gastric outlet obstruction, [31] obesity weight loss procedures, [32] esophageal tumors [33] [34] and others.
Kahaleh has created a personalized training program which allowed him to train physicians on endoscopic submucosal dissection (ESD) and POEM in the US, Italy, Spain, Colombia, Nicaragua, Ecuador, Mexico and Argentina. [35]
Dr. Kahaleh is the Founder and Director of the Therapeutic Endoscopic Ultrasound Society. [2] He is the Founder and CEO of the non-profit organization Innovative Digestive Health Education & Research Inc. (IDHER) since 2018 [3] He is also the Founder and CEO of the non-profit organization Foundation for Interventional and Therapeutic Endoscopy (FITE) since 2020 [4]
As the Founder of the Therapeutic Endoscopic Ultrasound Society, [36] along with colleague co-founder Todd Baron, Kahaleh and Monica Gaidhane have hosted the annual consortium on Therapeutic EUS during the Digestive Disease Week for the past 9 years. [37]
As the Founder of the Innovative Digestive Health Education & Research Inc. (IDHER), [3] along with co-founder Monica Gaidhane, Kahaleh has directed many continuing medical education conferences for Advanced Endoscopy including the annual Mid-Atlantic Gastrointestinal Interventional Course (MAGIC), [38] annual Mid-Atlantic Bariatric Endoscopy Course (MALBEC) [39] and annual Emerging Pancreatic Innovations Course (EPIC) [40] for the past 4 years.
Dr. Kahaleh helped develop the Foundation for Interventional and Therapeutic Endoscopy (FITE) [4] to fulfill unmet needs of Interventional and Therapeutic Endoscopists.
All three of his non-profit organizations focus on education, practice, research and improving patient outcomes with minimally invasive treatments. [2] [3] [4]
Gastroenterology is the branch of medicine focused on the digestive system and its disorders. The digestive system consists of the gastrointestinal tract, sometimes referred to as the GI tract, which includes the esophagus, stomach, small intestine and large intestine as well as the accessory organs of digestion which include the pancreas, gallbladder, and liver. The digestive system functions to move material through the GI tract via peristalsis, break down that material via digestion, absorb nutrients for use throughout the body, and remove waste from the body via defecation. Physicians who specialize in the medical specialty of gastroenterology are called gastroenterologists or sometimes GI doctors. Some of the most common conditions managed by gastroenterologists include gastroesophageal reflux disease, gastrointestinal bleeding, irritable bowel syndrome, inflammatory bowel disease (IBD) which includes Crohn's disease and ulcerative colitis, peptic ulcer disease, gallbladder and biliary tract disease, hepatitis, pancreatitis, colitis, colon polyps and cancer, nutritional problems, and many more.
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique that combines the use of endoscopy and fluoroscopy to diagnose and treat certain problems of the biliary or pancreatic ductal systems. It is primarily performed by highly skilled and specialty trained gastroenterologists. Through the endoscope, the physician can see the inside of the stomach and duodenum, and inject a contrast medium into the ducts in the biliary tree and pancreas so they can be seen on radiographs.
Gastrointestinal diseases refer to diseases involving the gastrointestinal tract, namely the esophagus, stomach, small intestine, large intestine and rectum, and the accessory organs of digestion, the liver, gallbladder, and pancreas.
Common bile duct stone, also known as choledocholithiasis, is the presence of gallstones in the common bile duct (CBD). This condition can cause jaundice and liver cell damage. Treatments include choledocholithotomy and endoscopic retrograde cholangiopancreatography (ERCP).
Magnetic resonance cholangiopancreatography (MRCP) is a medical imaging technique. It uses magnetic resonance imaging to visualize the biliary and pancreatic ducts non-invasively. This procedure can be used to determine whether gallstones are lodged in any of the ducts surrounding the gallbladder.
Endoscopic ultrasound (EUS) or echo-endoscopy is a medical procedure in which endoscopy is combined with ultrasound to obtain images of the internal organs in the chest, abdomen and colon. It can be used to visualize the walls of these organs, or to look at adjacent structures. Combined with Doppler imaging, nearby blood vessels can also be evaluated.
Double-balloon enteroscopy, also known as push-and-pull enteroscopy, is an endoscopic technique for visualization of the small bowel. It was developed by Hironori Yamamoto in 2001. It is novel in the field of diagnostic gastroenterology as it is the first endoscopic technique that allows for the entire gastrointestinal tract to be visualized in real time.
Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is inflammation of the bile duct, usually caused by bacteria ascending from its junction with the duodenum. It tends to occur if the bile duct is already partially obstructed by gallstones.
Postcholecystectomy syndrome (PCS) describes the presence of abdominal symptoms after a cholecystectomy.
Hemosuccus pancreaticus is a rare cause of hemorrhage in the gastrointestinal tract. It is caused by a bleeding source in the pancreas, pancreatic duct, or structures adjacent to the pancreas, such as the splenic artery, that bleed into the pancreatic duct, which is connected with the bowel at the duodenum, the first part of the small intestine. Patients with hemosuccus may develop symptoms of gastrointestinal hemorrhage, such as blood in the stools, maroon stools, or melena, which is a dark, tarry stool caused by digestion of red blood cells. They may also develop abdominal pain. It is associated with pancreatitis, pancreatic cancer and aneurysms of the splenic artery. Hemosuccus may be identified with endoscopy (esophagogastroduodenoscopy), where fresh blood may be seen from the pancreatic duct. Alternatively, angiography may be used to inject the celiac axis to determine the blood vessel that is bleeding. This may also be used to treat hemosuccus, as embolization of the end vessel may terminate the hemorrhage. However, a distal pancreatectomy—surgery to remove of the tail of the pancreas—may be required to stop the hemorrhage.
Therapeutic endoscopy is the medical term for an endoscopic procedure during which treatment is carried out via the endoscope. This contrasts with diagnostic endoscopy, where the aim of the procedure is purely to visualize a part of the gastrointestinal, respiratory or urinary tract in order to aid diagnosis. In practice, a procedure which starts as a diagnostic endoscopy may become a therapeutic endoscopy depending on the findings, such as in cases of upper gastrointestinal bleeding, or the finding of polyps during colonoscopy.
Sphincter of Oddi dysfunction refers to a group of functional disorders leading to abdominal pain due to dysfunction of the Sphincter of Oddi: functional biliary sphincter of Oddi and functional pancreatic sphincter of Oddi disorder. The sphincter of Oddi is a sphincter muscle, a circular band of muscle at the bottom of the biliary tree which controls the flow of pancreatic juices and bile into the second part of the duodenum. The pathogenesis of this condition is recognized to encompass stenosis or dyskinesia of the sphincter of Oddi ; consequently the terms biliary dyskinesia, papillary stenosis, and postcholecystectomy syndrome have all been used to describe this condition. Both stenosis and dyskinesia can obstruct flow through the sphincter of Oddi and can therefore cause retention of bile in the biliary tree and pancreatic juice in the pancreatic duct.
Peter B. Cotton is a British Gastroenterologist best known for his advancement in digestive disease, pioneering and naming the ERCP procedure and creating the Digestive Disease Center at the Medical University of South Carolina.
Amit Prabhakar Maydeo is an Indian gastroenterologist and endoscopy expert known for his pioneering efforts on therapeutic endoscopy and endoscopic retrograde cholangiopancreatography (ERCP). In 2013, he was honoured by the Government of India with the Padma Shri, the fourth highest civilian award, for his contributions to the fields of medicine and medical education. His son, Dr. Rohan Maydeo, is a surgeon from MGM Medical College and Hospital, Aurangabad.
Todd Huntley Baron is an American gastroenterologist who is Professor of Medicine at the University of North Carolina School of Medicine. Additionally, he currently serves as the Director of Advanced Therapeutic Endoscopy within UNC's Division of Gastroenterology and Hepatology. He is known for his publishing in the field of gastroenterology particularly in endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasound (EUS) and other advanced endoscopic procedures. He has developed interventional endoscopic techniques for the care of patients with gastrointestinal, liver and other medical conditions. He was the first to describe endoscopic drainage of the gallbladder, placement of a colonic stent, and endoscopic pancreatic necrosectomy.
In medicine, endoscopic sleeve gastroplasty (ESG) is a minimally-invasive, non-surgical (incisionless), endoscopic weight loss procedure that is part of the field of endoscopic bariatric therapies. To perform ESG, a physician sutures a patient’s stomach into a narrower, smaller tube-like configuration. The result is a more restricted stomach that forces patients to feel fuller sooner, eating fewer calories, which facilitates weight loss.
Pancreatic mucinous cystic neoplasm (MCN) is a type of cystic lesion that occurs in the pancreas. Amongst individuals undergoing surgical resection of a pancreatic cyst, about 23 percent were mucinous cystic neoplasms. These lesions are benign, though there is a high rate of progression to cancer. As such, surgery should be pursued when feasible. The rate of malignancy present in MCN is about 10 percent. If resection is performed before invasive malignancy develops, prognosis is excellent. The extent of invasion is the single most important prognostic factor in predicting survival.
Nib Soehendra is a German surgeon known for numerous contributions to the field of endoscopy and therapeutic endoscopy.
Kenneth Frank Binmoeller is a medical doctor and author of multiple scientific contributions and over 300 publications, as well as the inventor of the lumen-apposing metal stent (LAMS) and AXIOS System. These are medical devices used to relieve blockages while creating a direct connection between two bodily structures. He practices in the field of Gastroenterology with a specialty of Advanced Endoscopic Intervention. Binmoeller has been published for his innovations in medical devices and training in the field of Endoscopy.
Biliary endoscopic sphincterotomy is a procedure where the sphincter of Oddi and the segment of the common bile duct where it enters the duodenum are cannulated and then cut with a sphincterotome, a device that includes a wire which cuts with an electric current (electrocautery).
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