Mona Mostafa Mohamed

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Mona Mostafa Mohamed
Academic work
InstitutionsCairo University

Mona Mostafa Mohamed is an Egyptian doctor and head of the Cancer Biology Research Laboratory at Cairo University in Giza, Egypt. In 2005 she was granted the Avon Foundation-AACR International Scholar Award for her dedication to breast cancer research. Mohamed is known for her research on locally activated breast cancer, metastatic breast cancer, and inflammatory breast cancer.

Contents

Education and career

Mohamed has a B.S. (1991) and a Ph.D. (2002) from Cairo University. [1] She was a postdoctoral researcher at Wayne State School of Medicine from 2005 until 2007. [2] [ better source needed ] In 2007, she was awarded a start up fund from the Avon Foundation to create the first research lab in Egypt specific to studying breast cancer biology which is located at Cairo University. [3] As of 2022 she is an associate professor at Cairo University. [4]

Mohamed is known for her work in breast cancer, particularly on the role of multi functional enzymes. [5] Her research has examined the conditions for women with inflammatory breast cancer in Egypt, [6] and white blood cells from patients with inflammatory breast cancer. [7] [8]

Selected publications

Awards and honors

In 2005, Mohamed won the Avon Foundation International Scholar Award in Breast Cancer Research. [9] [10] In 2012, she was admitted into the United States' State Departments' Women in Science Hall of Fame for the Middle East and North Africa. [9] [11] [ better source needed ] In 2014 she was awarded the Arab Women Organization Prize in Science and Technology. [12] [ better source needed ]

Related Research Articles

<span class="mw-page-title-main">Metastasis</span> Spread of a disease inside a body

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<span class="mw-page-title-main">Tumor necrosis factor</span> Protein

Tumor necrosis factor is an adipokine and a cytokine. TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain.

Stromal cells, or mesenchymal stromal cells, are differentiating cells found in abundance within bone marrow but can also be seen all around the body. Stromal cells can become connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary. They are cells that support the function of the parenchymal cells of that organ. The most common stromal cells include fibroblasts and pericytes. The term stromal comes from Latin stromat-, "bed covering", and Ancient Greek στρῶμα, strôma, "bed".

<span class="mw-page-title-main">Oleocanthal</span> Chemical compound

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Intravasation is the invasion of cancer cells through the basement membrane into a blood or lymphatic vessel. Intravasation is one of several carcinogenic events that initiate the escape of cancerous cells from their primary sites. Other mechanisms include invasion through basement membranes, extravasation, and colonization of distant metastatic sites. Cancer cell chemotaxis also relies on this migratory behavior to arrive at a secondary destination designated for cancer cell colonization.

<span class="mw-page-title-main">Indoleamine 2,3-dioxygenase</span> Mammalian protein found in Homo sapiens

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols. Furthermore, there is data implicating a role for IDO1 in the modulation of vascular tone in conditions of inflammation via a novel pathway involving singlet oxygen.

<span class="mw-page-title-main">Colony stimulating factor 1 receptor</span> Protein found in humans

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Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors. They are heavily involved in cancer-related inflammation. Macrophages are known to originate from bone marrow-derived blood monocytes or yolk sac progenitors, but the exact origin of TAMs in human tumors remains to be elucidated. The composition of monocyte-derived macrophages and tissue-resident macrophages in the tumor microenvironment depends on the tumor type, stage, size, and location, thus it has been proposed that TAM identity and heterogeneity is the outcome of interactions between tumor-derived, tissue-specific, and developmental signals.

<span class="mw-page-title-main">Tumor microenvironment</span> Surroundings of tumors including nearby cells and blood vessels

The tumor microenvironment (TME) is a complex ecosystem surrounding a tumor, composed of a variety of non-cancerous cells including blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). Mutual interaction between cancer cells and the different components of the TME support its growth and invasion in healthy tissues which correlates with tumor resistance to current treatments and poor prognosis. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells.

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage.

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A cancer-associated fibroblast (CAF) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling of the extracellular matrix or by secreting cytokines. CAFs are a complex and abundant cell type within the tumour microenvironment; the number cannot decrease, as they are unable to undergo apoptosis.

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<span class="mw-page-title-main">Reduction-sensitive nanoparticles</span> Drug delivery method

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References

  1. "Dr. Mona Mostafa Mohamed's biography". Cairo University Scholars.
  2. "Mentorship with Dr. Sloane leads to new breast cancer research lab in Egypt". School of Medicine News. May 5, 2009. Retrieved 2022-10-29.
  3. Karim, Ahmed A.; Khalil, Radwa; Moustafa, Ahmed (2021-07-27). Female Pioneers from Ancient Egypt and the Middle East: On the Influence of History on Gender Psychology. Springer Nature. p. 55. ISBN   978-981-16-1413-2.
  4. "Mona Mostafa Mohamed". Cairo University. Retrieved 2022-12-17.
  5. Mohamed, Mona Mostafa; Sloane, Bonnie F. (2006). "multifunctional enzymes in cancer". Nature Reviews Cancer. 6 (10): 764–775. doi:10.1038/nrc1949. ISSN   1474-175X. PMID   16990854. S2CID   26463930.
  6. Mohamed, MM; El-Shinawi, M; Cavallo-Medved, D; Sobhy, M; Nouh, MA; Abdelwahab, SF; Sloane, BF (2009). "Monocytes/macrophages and natural killer cells characterize the tumor microenvironment of inflammatory breast cancer in Egyptian patients". Cancer Research. 69 (2_Supplement): 1054. doi:10.1158/0008-5472.sabcs-1054. ISSN   0008-5472.
  7. Mohamed, Mona M.; El-Ghonaimy, Eslam A.; Nouh, Mohamed A.; Schneider, Robert J.; Sloane, Bonnie F.; El-Shinawi, Mohamed (2014-01-01). "Cytokines secreted by macrophages isolated from tumor microenvironment of inflammatory breast cancer patients possess chemotactic properties". The International Journal of Biochemistry & Cell Biology. 46: 138–147. doi:10.1016/j.biocel.2013.11.015. ISSN   1357-2725. PMC   3928544 . PMID   24291763.
  8. Mohamed, Hossam Taha; El-Husseiny, Noura; El-Ghonaimy, Eslam A.; Ibrahim, Sherif Abdelaziz; Bazzi, Zainab A.; Cavallo-Medved, Dora; Boffa, Michael B.; El-Shinawi, Mohamed; Mohamed, Mona Mostafa (2018-03-01). "IL-10 correlates with the expression of carboxypeptidase B2 and lymphovascular invasion in inflammatory breast cancer: The potential role of tumor infiltrated macrophages". Current Problems in Cancer. SI: Cervical Cancer. 42 (2): 215–230. doi:10.1016/j.currproblcancer.2018.01.009. ISSN   0147-0272. PMID   29459177.
  9. 1 2 "Ambassador Patterson Honors Egyptian Women in Science". Targeted News Service; Washington, D.C. [Washington, D.C]. 23 April 2012 via ProQuest.
  10. Sciences (TWAS), The World Academy of; Alexandrina, Bibliotheca; Council, National Research; Studies, Division on Earth and Life; Sciences, Board on Life; Potential, Committee on Developing a Framework for an International Faculty Development Project on Education About Research in the Life Sciences with Dual Use (2013-07-28). Developing Capacities for Teaching Responsible Science in the MENA Region: Refashioning Scientific Dialogue. National Academies Press. ISBN   978-0-309-28639-8.
  11. "CAIRO - Mona Mostafa Mohamed". U.S. Embassy in Jordan. Retrieved 2022-10-29.
  12. "Mona Mostafa". Galala University. Retrieved 2022-03-14.