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Acyl-CoA thioesterase 9 is a protein that is encoded by the human ACOT9 gene. It is a member of the acyl-CoA thioesterase superfamily, which is a group of enzymes that hydrolyze Coenzyme A esters. There is no known function, however it has been shown to act as a long-chain thioesterase at low concentrations, and a short-chain thioesterase at high concentrations.
Acyl-CoA:lysocardiolipin acyltransferase-1 (ALCAT1) is a polyglycerophospholipid acyltransferase of the endoplasmic reticulum which is primarily known for catalyzing the acylation of monolysocardiolipin back into cardiolipin, although it does catalyze the acylation of other polyglycerophospholipids.
References
- ↑ Schlame M, Rüstow B (December 1990). "Lysocardiolipin formation and reacylation in isolated rat liver mitochondria". The Biochemical Journal. 272 (3): 589–95. doi:10.1042/bj2720589. PMC 1149749 . PMID 2268287.
- ↑ Ma BJ, Taylor WA, Dolinsky VW, Hatch GM (October 1999). "Acylation of monolysocardiolipin in rat heart". Journal of Lipid Research. 40 (10): 1837–45. doi: 10.1016/S0022-2275(20)34900-2 . PMID 10508203.
- ↑ Taylor WA, Hatch GM (April 2003). "Purification and characterization of monolysocardiolipin acyltransferase from pig liver mitochondria". The Journal of Biological Chemistry. 278 (15): 12716–21. doi: 10.1074/jbc.M210329200 . PMID 12569106.
- 1 2 3 Taylor WA, Hatch GM (October 2009). "Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)". The Journal of Biological Chemistry. 284 (44): 30360–71. doi: 10.1074/jbc.M109.048322 . PMC 2781591 . PMID 19737925.
- ↑ Danos M, Taylor WA, Hatch GM (February 2008). "Mitochondrial monolysocardiolipin acyltransferase is elevated in the surviving population of H9c2 cardiac myoblast cells exposed to 2-deoxyglucose-induced apoptosis". Biochemistry and Cell Biology. 86 (1): 11–20. doi:10.1139/O07-156. PMID 18364741.
- ↑ Saini-Chohan HK, Holmes MG, Chicco AJ, Taylor WA, Moore RL, McCune SA, Hickson-Bick DL, Hatch GM, Sparagna GC (August 2009). "Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure". Journal of Lipid Research. 50 (8): 1600–8. doi: 10.1194/jlr.M800561-JLR200 . PMC 2724040 . PMID 19001357.
- ↑ Taylor WA, Mejia EM, Mitchell RW, Choy PC, Sparagna GC, Hatch GM (2012). "Human trifunctional protein alpha links cardiolipin remodeling to beta-oxidation". PLOS ONE. 7 (11): e48628. Bibcode:2012PLoSO...748628T. doi: 10.1371/journal.pone.0048628 . PMC 3494688 . PMID 23152787.
- ↑ Mutter T, Dolinsky VW, Ma BJ, Taylor WA, Hatch GM (March 2000). "Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart". The Biochemical Journal. 346 Pt 2 (2): 403–6. doi:10.1042/0264-6021:3460403. PMC 1220866 . PMID 10677359.