Morbidity and Mortality Weekly Report

Last updated

Publication history

MMWR has its roots in the establishment of the Public Health Service (PHS). On January 3, 1896, the Public Health Service began publishing Public Health Reports . Morbidity and mortality statistics were published in Public Health Reports until January 20, 1950, when they were transferred to a new publication of the PHS National Office of Vital Statistics called the Weekly Morbidity Report. In 1952, NOVS changed the name of this publication to the Morbidity and Mortality Weekly Report, which continues through the current day (2020).

Notable articles

Several notable articles have been published in the report including:

On the other hand, there have been articles that have been controversial, such as a report stating a low concerns for risks of elevated blood levels of lead in Washington, DC (April 2004). [10] The article was notable and later criticized [11] for not emphasizing the risks, and now is available together with two amending "notices to the readers" by CDC from 2010.

First report of AIDS

Five cases of Pneumocystis carinii pneumonia (PCP) were reported in what turned out to be the first reporting of AIDS in the medical literature (June 5, 1981). [12] Los Angeles-based general practitioner Joel Weisman and immunologist Michael S. Gottlieb of the UCLA Medical Center had encountered a series of gay male patients with symptoms that appeared to be immune system disorders including significant loss of weight and swollen lymph nodes, accompanied by fever and rashes, in addition to two patients with chronic diarrhea, depressed white blood cell counts and fungal infections. Gottlieb diagnosed these and a number of his other patients as having pneumocystis pneumonia. A report they jointly wrote and published in the June 5, 1981, issue of Morbidity and Mortality Weekly Report, described their patients as "5 young men, all active homosexuals, [who] were treated for biopsy-confirmed Pneumocystis carinii pneumonia at 3 different hospitals in Los Angeles, California" of which "[t]wo of the patients died" by the time of the original report. [13] This notice has been recognized as the first published report marking the official start of the AIDS pandemic and as "the first report on AIDS in the medical literature". [14]

Drinking water lead report controversy

Background

Between 2001 and 2003, various tests showed that the lead content in drinking water in Washington DC more that 10% of the tests were higher than 15 ppb (parts per billion), which was the "action level" fixed by U.S. Environmental Protection Agency (EPA) for stagnant first draw water, and not indicative of typical usage. Some of the tests were prompted by EPA's lead and copper rule, while others were conducted by professor Marc Edwards, while trying to find the causes of an increased rate of pinhole leaks in copper water pipes. He found some rather high values in a few households, sometimes exceeding 1250 PPM. [15] From 2002 on the matter started to be noted by news media. [16] [17]

Lead is well known to have toxic effects, especially for embryos and small children. Even in small doses, lead poisoning may lead to permanent intelligence deficiencies and concentration difficulties.

Report details

On March 30, 2004, an "MMWR dispatch", Blood Lead Levels in Residents of Homes with Elevated Lead in Tap Water – District of Columbia, 2004 was made available on the MMWR web site. It was then published by CDC as "MMWR Weekly, April 2, 2004 / 53(12); 268–270". [10] Its principal author was Mary Jean Brown, who was the head of the lead poisoning branch of CDC. The report "summarizes the results of the preliminary investigations, which indicated that the elevated water lead levels might have contributed to a small increase in blood lead levels (BLLs)". The report describes the background, and the various kinds of blood tests it employed, and explicitly states: "All blood tests were used in this analysis." There is no mention at all of any test results not being available, not even in the caveat section, where other potential sources of error are discussed.

The report concludes that the high amounts of lead in the drinking water may have led to a slight rise of the blood levels; however, it claimed that "no children were identified with BLLs >10 μg/dL, even in homes with the highest water lead levels". It notes that 10 μg/dL was "CDC's BLL of concern for children" since 1991. The report also claimed that the average levels were sinking with time. On the other hand, the report found some cases of children with BLLs > 5 μg/dL; and also stated that actually "no safe BLL has been identified". Therefore, the report recommends that efforts should be made to eliminate lead in children's blood entirely, and in particular, that the authorities should take measures to ensure that the amount of lead in drinking water always should be less than 15 PPM.

The report does not in itself provide any recommendations to the ordinary Washington, DC inhabitants, but it notes that the District of Columbia Department of Health has "recommended that young children and pregnant and breast-feeding women refrain from drinking unfiltered tap water".

Criticism of the report

The report later was strongly criticized, by Marc Edwards, some news media, and ultimately by the United States House Committee on Science, Space and Technology.

Marc Edwards initiated a study, which included investigating health aspects. At first, he was sponsored by EPA; but when they interrupted their support, he financed it out of his own pocket. He claimed that this study, employing raw data also available to the CDC study, had found clear evidence of a correlation between rather high amounts of lead in the water on the one hand, and rather high amounts of lead in the blood of children on the other. Specifically, there were cases known to him, of children with BBL clearly exceeding 10 μg/dL; but these cases were absent from the material presented in the MMWR. Marc Edwards and pediatrician Dana Best of Children's National Medical Center in Washington, actually found a marked increase in high-level results from 2001 to 2004, among small children. [18] The results of Marc Edwards et al. came from analysis of the same raw data as those underlying the 2004 CDC report. In 2007, Edwards wrote to the CDC's associate director of science, James Stephens, questioning the report's conclusions and methodology, and the competence of its principal author. In 2008, Stephens answered him: "We have examined CDC's role in the study and have found no evidence of misconduct." [18]

According to Salon, there was an evident dip in critical year 2003 (when the lead in the drinking water peaked), in the data present in the CDC files, there were test results for 15,755 children in 2002, only 9,765 children in 2003, and 18,038 children in 2004, At the time, Mary Jean Brown had questioned the dip, and had gotten the answer that it was due to a private laboratory not having reported the low values they had found. She had accepted the answer. [18] Salon also claimed that the CDC had found a link between lead pipes and high childhood blood lead levels in the district in 2007, but had not publicized the study. [18] [19]

In 2009, the United States House of Representatives' Science and Technology Committee opened a congressional investigation into the 2004 CDC report. [19] Investigators found that although the CDC and city health department reported dangerous lead levels in 193 children in 2003, the actual number was 486 according to records taken directly from the testing laboratories. [19] In 2010, in their final report, the committee concluded that the CDC knowingly used flawed data in drafting the report, leading to "scientifically indefensible" claims in the 2004 paper. [11] It also cited the CDC for failing to publicize later research showing that the harm was more serious than the 2004 report suggested. [11]

Response to the criticism

The CDC did not withdraw the report, but in 2010 amended it with two "notices to the readers", with the following explanations. The CDC maintained that the report essentially is correct, but admitted that the presentation was misleading, as regards the absence of data, and as regards the claim that no children with BLLs above the alert threshold 10 μg/dL were found. That claim, they stated, "was misleading because it referred only to data from the cross-sectional study and did not reflect findings of concern from the separate longitudinal study that showed that children living in homes serviced by a lead water pipe were more than twice as likely as other DC children to have had a blood lead level ≥10 μg/dL". Moreover, the CDC emphasizes, that the original report did warn for negative effects on health of the BLLs it did report, did note that there are no safe known limits, and did demand actions for reducing the level of lead in drinking water. They also maintain, that the overall trend was towards sinking BLLs, even when the full data set is taken into consideration. [10]

Political pressure during the COVID-19 pandemic

During the COVID-19 pandemic in the United States, MMWR came under pressure from political appointees at the Department of Health and Human Services (HHS) to modify its reporting so as not to conflict with what President Donald Trump was saying about the pandemic. [20] Starting in June 2020, Michael Caputo, the HHS assistant secretary for public affairs, and his chief advisor Paul Alexander tried to change, delay, suppress, and retroactively edit MMWR stories about the effectiveness of potential treatments for COVID-19, the transmissibility of the virus, and other issues where the president had taken a public stance. [20] Alexander tried unsuccessfully to get personal approval of all issues of MMWR before they went out. [21] Caputo claimed this oversight was necessary because MMWR reports were being tainted by "political content"; he demanded to know the political leanings of the scientists who reported that hydroxychloroquine had little benefit as a treatment while Trump was saying the opposite. [20] In emails to the head of CDC, Alexander accused CDC scientists of attempting to "hurt the president" and writing "hit pieces on the administration". [22] On September 14, 2020, the Select Subcommittee on the Coronavirus Crisis of the U.S. House of Representatives requested "transcribed interviews" with seven CDC and HHS personnel "to determine the scope of political interference with CDC's scientific reports and other efforts to combat the pandemic, the impact of this interference on CDC's mission, whether this interference is continuing, and the steps that Congress may need to take to stop it before more Americans die needlessly." [23] [24]

An analysis of studies in MMWR [25] found the agency promoted the effectiveness of masks using unreliable data with conclusions unsupported by evidence. The journal made positive findings about the efficacy of masks 75 percent of the time, despite only 30 percent of studies testing masks, and less than 15 percent having “statistically significant results.” Researchers said that political involvement and lack of accountability by outside experts unaffiliated with the CDC could influence the journal’s ability to evaluate scientific data objectively.

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References

  1. ↑ Morbidity and Mortality Weekly Report: About Us, Centers for Disease Control and Prevention. Retrieved July 24, 2009.
  2. ↑ Morbidity and Mortality Weekly Report Staff, Centers for Disease Control and Prevention. Retrieved February 1, 2019.
  3. ↑ MMWR Weekly: Past Volumes (1982–2010)
  4. ↑ Centers for Disease Control Prevention (CDC) (5 September 2003). "Public health dispatch: multistate outbreak of hepatitis A among young adult concert attendees – United States, 2003". MMWR Morb Mortal Wkly Rep. 52 (35): 844–5. PMID   12966361.
  5. ↑ O' Neil, John. "VITAL SIGNS: HAZARDS; Outbreak on the Concert Circuit", The New York Times , September 9, 2003. Retrieved July 24, 2009.
  6. ↑ via Associated Press. "National Briefing | Science and Health; Count Of 'choking Game' Fatalities", The New York Times , February 15, 2008. Retrieved July 24, 2009.
  7. ↑ Bakalar, Nicholas. "Northwest Fishery Posts Highest Fatality Rate", The New York Times , May 13, 2008. Retrieved July 24, 2009.
  8. ↑ Bakalar, Nicholas. "Smoking Ban Improves a City's Health", The New York Times , January 12, 2009.
  9. ↑ Centers for Disease Control Prevention (CDC) (24 April 2009). "Swine Influenza A (H1N1) Infection in Two Children – Southern California, March–April 2009". MMWR Morb Mortal Wkly Rep. 58 (15): 400–2. PMID   19390508.
  10. 1 2 3 Centers for Disease Control Prevention (CDC) (2 April 2004). "Blood Lead Levels in Residents of Homes with Elevated Lead in Tap Water – District of Columbia, 2004". MMWR Morb Mortal Wkly Rep. 53 (12): 268–270. PMID   15057194.
  11. 1 2 3 Leonnig, Carol D. (May 20, 2010). "CDC mislead District residents about lead levels in water, House probe finds". The Washington Post. Washington, DC. Retrieved June 22, 2011.
  12. ↑ Centers for Disease Control Prevention (CDC) (1 June 2001). "First report of AIDS" (PDF). MMWR Morb Mortal Wkly Rep. 50 (21): 429. PMID   11478306. Reprint of 5 June 1981 report.
  13. ↑ Centers for Disease Control Prevention (CDC) (30 August 1996). "Pneumocystis pneumonia – Los Angeles. 1981". MMWR Morb Mortal Wkly Rep. 45 (34): 729–733. PMID   8778581. As PDF Reprint of the June 4, 1981 report.
  14. ↑ via Associated Press . "Doctor Who Co-Authored First AIDS Report Dies", The New York Times , July 23, 2009. Retrieved July 24, 2009.[ dead link ]
  15. ↑ Home-Douglas, Pierre (November 2004). "The Water Guy". Prism. 14 (3). American Society for Engineering Education. Retrieved June 15, 2011.
  16. ↑ Levin, Josh (October 18, 2002). "Plumbing the Depths: the EPA finds too much lead in D.C. tap water". Washington City Paper. Washington, DC.
  17. ↑ Nakamura, David (January 31, 2004). "Water in D.C. Exceeds EPA Lead Limit". Washington Post. Washington, DC. p. A01.
  18. 1 2 3 4 Renner, Rebecca (April 10, 2009). "Health agency covered up lead harm". Salon.com . Salon Media Group. Retrieved June 15, 2011.
  19. 1 2 3 Leonnig, Carol D. (August 4, 2009). "D.C., U.S. Underreported Number of Kids With High Lead Levels by More Than Half". Washington Post . Washington, DC. Retrieved June 22, 2011.
  20. 1 2 3 Diamond, Dan (September 11, 2020). "Trump officials interfered with CDC reports on Covid-19". Politico. Retrieved 14 September 2020.
  21. ↑ Sun, Lena H. (September 12, 2020). "Trump officials seek greater control over CDC reports on coronavirus". The Washington Post. Retrieved 14 September 2020.
  22. ↑ "Political Appointees Meddled in C.D.C.'s 'Holiest of the Holy' Health Reports". The New York Times. September 12, 2020. Retrieved 14 September 2020.
  23. ↑ "Select Subcommittee on the Coronavirus Crisis of the U. S. House of Representatives September 14th, 2020 letter to Secretary Azar and Director Redfield". documentcloud.org. 2020-09-16. Archived from the original on 2020-09-16. Retrieved 2020-09-16. (...) to determine the scope of political interference with CDC's scientific reports and other efforts to combat the pandemic, the impact of this interference on CDC's mission, whether this interference is continuing, and the steps that Congress may need to take to stop it before more Americans die needlessly.
  24. ↑ Craggs, Samantha (2020-09-15). "Trump adviser tied to efforts to downplay COVID-19 not on McMaster's payroll, university says". CBC.CA. Canadian Broadcast Corporation. Archived from the original on 2020-09-15. Retrieved 2020-09-15. Alexander is scheduled to appear before a congressional subcommittee on Sept. 24, and bring any emails or reports related to COVID-19 deaths and infections, hydroxychloroquine and the impact the virus has on children. He did not respond to a request for an interview from CBC News. The committee will grill him about his recent demands on behalf of the Trump administration to alter weekly Centers for Disease Control and Prevention (CDC) reports – alterations that appear to downplay the impact of the pandemic on schools. In one email, the Washington Post reports, Alexander accused the CDC of writing "hit pieces on the administration" with its Morbidity and Mortality Weekly Report.
  25. ↑ "An analysis of studies pertaining to masks in Morbidity and Mortality Weekly Report: Characteristics and quality of all studies from 1978 to 2023". 2023-07-11. medRxiv   10.1101/2023.07.07.23292338v1 .
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