Myrotoxin B

Myrotoxin B

Identifiers
CAS Number	99486-49-4  Y
3D model (JSmol)	Interactive image
PubChem CID	6540635
UNII	1PX13P7HGK  Y
InChI InChI=1S/C29H34O11/c1-15-10-20-27(12-18(15)37-16(2)30)13-35-25(33)24-28(40-24)8-9-34-17(23(28)32)6-4-5-7-22(31)39-19-11-21(38-20)29(14-36-29)26(19,27)3/h5-7,10,18-21,23-24,32H,4,8-9,11-14H2,1-3H3/b7-5-,17-6-/t18-,19+,20+,21+,23?,24+,26?,27+,28+,29-/m0/s1 Key: BDPRKFBFVAVFJK-YMQWBDTMSA-N
SMILES CC1=C[C@]2([H])[C@]([C@@](C)3[C@]4(CO4)[C@@]([H])(C[C@H]3OC5=O)O2)(CO[C@]([C@@H](O7)[C@]([C@H]/6O)7CCOC6=C/C/C=C\5)=O)C[C@@H]1OC(C)=O
Properties
Chemical formula	C29H34O11
Molar mass	558.580 g·mol−1
Melting point	195 to 197 °C (383 to 387 °F; 468 to 470 K) [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y  verify  (what is  YN ?) Infobox references

Myrotoxin B is a macrocyclic trichothecene first isolated in 1985. ^[1] It was tested on Swiss mice and found to be very toxic, though not the most toxic of the three toxins that were tested at that time. ^[2] It has also been isolated from Myrothecium roridum , a pathogen leaf spot that affects mulberry, though it is unknown if it is used as a pathotoxin. ^[3]

References

1. Jarvis, B. B.; Lee, Y.-W.; Cömezoḡlu, F. T.; Cömezoḡlu, S. N.; Bean, G. A. (1985). "Myrotoxins: a new class of macrocyclic trichothecenes". Tetrahedron Letters. 26 (40): 4859–62. doi:10.1016/S0040-4039(00)94970-0.
2. Schiefer, H. B.; Hancock, D. S.; Jarvis, B. B. (1989). "Toxicology of Novel Macrocyclic Trichothecenes, Baccharinoid B4, Myrotoxin B, and Roritoxin B". Zentralblatt für Veterinärmedizin. Reihe A. 36 (2): 152–60. doi:10.1111/j.1439-0442.1989.tb00715.x. ISSN   0514-7158. PMID   2501953.
3. Murakami, R.; Shirata, A. (2005). "Myrotoxin B Detection from Mulberry Leaves Infected with Myrothecium roridum, cause Myrothecium Leaf Spot of Mulberry, and Possible Roles in Pathogenicity" (pdf). Japanese Journal of Phytopathology. 71 (2): 91–100. doi: 10.3186/jjphytopath.71.91 .