N1-Methyl-4-pyridone-3-carboxamide

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N1-Methyl-4-pyridone-3-carboxamide
N-Methyl-4-pyridone-3-carboxamide.svg
Names
IUPAC name
1-Methyl-4-oxopyridine-3-carboxamide
Other names
4PY
Identifiers
3D model (JSmol)
PubChem CID
  • CN1C=CC(=O)C(=C1)C(=O)N
Properties
C7H8N2O2
Molar mass 152.153 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N1-Methyl-4-pyridone-3-carboxamide, also abbreviated as 4PY, is a breakdown product of niacin and NAD, [1] that is associated with an increased risk of cardiovascular disease. [2] It has 2 carbonyl groups that are close to each other. [3] [4] [5]

References

  1. ↑ Cosmetic Ingredient Review Expert Panel (2005). "Final report of the safety assessment of niacinamide and niacin". International Journal of Toxicology. 24 (Suppl 5): 1–31. doi:10.1080/10915810500434183. PMID   16596767. S2CID   208149068.
  2. ↑ Ferrell M, Wang Z, Anderson JT, Li XS, Witkowski M, DiDonato JA, Hilser JR, Hartiala JA, Haghikia A, Cajka T, Fiehn O, Sangwan N, Demuth I, König M, Steinhagen-Thiessen E, Landmesser U, Tang WH, Allayee H, Hazen SL (February 2024). "A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk". Nature Medicine. 30 (2): 424–434. doi:10.1038/s41591-023-02793-8. PMC   11841810 . PMID   38374343.
  3. ↑ "Cleveland Clinic-Led Study Discovers Link between High Levels of Niacin – a Common B Vitamin – and Heart Disease". 19 February 2024.
  4. ↑ "N1-Methyl-4-pyridone-3-carboxamide". Toxin and Toxin Target Database (T3DB). T3D4179.
  5. ↑ MasterJohn C (24 February 2024). "NMN Probably Won't Make You Live Forever". Substack.


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