NADSYN1

NADSYN1
Identifiers
Aliases	NADSYN1 , NAD synthetase 1, VCRL3
External IDs	OMIM: 608285; MGI: 1926164; HomoloGene: 6098; GeneCards: NADSYN1; OMA:NADSYN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.4 Start 71,453,109 bp [1] End 71,524,107 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F5 Start 143,349,321 bp [2] End 143,376,586 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube granulocyte mucosa of transverse colon anterior pituitary minor salivary glands left ovary right lung skin of leg rectum body of stomach Top expressed in duodenum jejunum proximal tubule yolk sac right kidney left lobe of liver epithelium of small intestine colon ileum human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity protein binding ATP binding glutaminase activity NAD+ synthase (glutamine-hydrolyzing) activity Cellular component cytoplasm cytosol Biological process nitrogen compound metabolic process NAD metabolic process NAD biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55191 78914 Ensembl ENSG00000172890 ENSMUSG00000031090 UniProt Q6IA69 Q711T7 RefSeq (mRNA) NM_018161 NM_030221 NM_001308092 NM_001308095 RefSeq (protein) NP_060631 NP_001295024 NP_084497 Location (UCSC) Chr 11: 71.45 – 71.52 Mb Chr 7: 143.35 – 143.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutamine-dependent NAD(+) synthetase is an enzyme that in humans is encoded by the NADSYN1 gene. ^{[5] [6]}

Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD). ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000172890 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031090 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hara N, Yamada K, Terashima M, Osago H, Shimoyama M, Tsuchiya M (Mar 2003). "Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency". J Biol Chem. 278 (13): 10914–21. doi: 10.1074/jbc.M209203200 . PMID   12547821.
6. "Entrez Gene: NADSYN1 NAD synthetase 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.