NAT10

NAT10
Identifiers
Aliases	NAT10 , ALP, NET43, N-acetyltransferase 10, Kre33
External IDs	OMIM: 609221; MGI: 2138939; HomoloGene: 6785; GeneCards: NAT10; OMA:NAT10 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p13 Start 34,105,617 bp [1] End 34,147,670 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E2 Start 103,551,601 bp [2] End 103,591,615 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve skin of leg skin of abdomen ventricular zone right ovary left ovary Achilles tendon body of pancreas tonsil right uterine tube Top expressed in spermatocyte epiblast neural layer of retina yolk sac primitive streak spermatid tail of embryo Paneth cell lens ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding acyltransferase activity protein binding ATP binding N-acetyltransferase activity tRNA binding tRNA N-acetyltransferase activity rRNA cytidine N-acetyltransferase activity RNA binding DNA polymerase binding Cellular component nucleolus membrane nucleus telomerase holoenzyme complex nucleoplasm midbody 90S preribosome Biological process rRNA processing negative regulation of telomere maintenance via telomerase tRNA processing ncRNA processing rRNA metabolic process rRNA modification tRNA wobble cytosine modification tRNA acetylation rRNA acetylation involved in maturation of SSU-rRNA ribosomal small subunit biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55226 98956 Ensembl ENSG00000135372 ENSMUSG00000027185 UniProt Q9H0A0 Q8K224 RefSeq (mRNA) NM_001144030 NM_024662 NM_153126 RefSeq (protein) NP_001137502 NP_078938 NP_694766 Location (UCSC) Chr 11: 34.11 – 34.15 Mb Chr 2: 103.55 – 103.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

N-acetyltransferase 10 is an enzyme that in humans is encoded by the NAT10 gene. ^{[5] [6]} NAT10 moderates the formation of N4-acetylcytidine RNA modifications on tRNA, rRNA, and mRNA. ^{[7] [8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000135372 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027185 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lv J, Liu H, Wang Q, Tang Z, Hou L, Zhang B (Nov 2003). "Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT". Biochemical and Biophysical Research Communications. 311 (2): 506–13. doi:10.1016/j.bbrc.2003.09.235. PMID   14592445.
6. "Entrez Gene: NAT10 N-acetyltransferase 10".
7. Jin, Gehui; Xu, Mingqing; Zou, Mengsha; Duan, Shiwei (June 2020). "The Processing, Gene Regulation, Biological Functions, and Clinical Relevance of N4-Acetylcytidine on RNA: A Systematic Review". Molecular Therapy - Nucleic Acids. 20: 13–24. doi:10.1016/j.omtn.2020.01.037.
8. Liu, Rucong; Wubulikasimu, Zibaguli; Cai, Runze; Meng, Fanyi; Cui, Qinghua; Zhou, Yuan; Li, Yang (8 September 2023). "NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells". Nucleic Acids Research. 51 (16): 8514–8531. doi:10.1093/nar/gkad628.
9. Tardu, Mehmet; Jones, Joshua D.; Kennedy, Robert T.; Lin, Qishan; Koutmou, Kristin S. (19 July 2019). "Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs". ACS Chemical Biology. 14 (7): 1403–1409. doi:10.1021/acschembio.9b00369.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID   11214970.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (Nov 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Liu H, Ling Y, Gong Y, Sun Y, Hou L, Zhang B (Jun 2007). "DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation". Molecular and Cellular Biochemistry. 300 (1–2): 249–58. doi:10.1007/s11010-006-9390-5. PMID   17180247. S2CID   2589666.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Chi YH, Haller K, Peloponese JM, Jeang KT (Sep 2007). "Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes" (PDF). The Journal of Biological Chemistry. 282 (37): 27447–58. doi: 10.1074/jbc.M703098200 . PMID   17631499. S2CID   44621298.