NDST2

NDST2
Identifiers
Aliases	NDST2 , HSST2, NST2, N-deacetylase/N-sulfotransferase 2, N-deacetylase and N-sulfotransferase 2, N-HSST 2
External IDs	OMIM: 603268 MGI: 97040 HomoloGene: 20803 GeneCards: NDST2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	73,811,798 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	20,784,630 bp
RNA expression pattern
	Top expressed in
	spleen; ; blood; ; bone marrow; ; thymus; ; gastric mucosa; ; minor salivary gland; ; sural nerve; ; appendix; ; lymph node; ; monocyte;
	Top expressed in
	dermis; ; lip; ; Ankle joint; ; yolk sac; ; spermatocyte; ; cerebellar cortex; ; proximal tubule; ; molar; ; internal carotid artery; ; mirror;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; sulfotransferase activity ; catalytic activity ; hydrolase activity ; N-acetylglucosamine deacetylase activity ; [heparan sulfate-glucosamine N-sulfotransferase activity]; deacetylase activity ; heparan sulfate sulfotransferase activity ; heparan sulfate N-acetylglucosaminyltransferase activity ;
Cellular component	integral component of membrane ; Golgi membrane ; Golgi apparatus ; membrane ;
Biological process	metabolism ; heparan sulfate proteoglycan biosynthetic process ; heparin biosynthetic process ; glycosaminoglycan biosynthetic process ; regulation of angiotensin levels in blood ; cellular process ; sulfur compound metabolic process ; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	8509
	17423
	ENSG00000166507
	ENSMUSG00000039308
	P52849
	P52850
	NM_001330107 ; NM_003635
	NM_010811
	NP_001317036 ; NP_003626
	NP_034941
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 05, 2022

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.^[5]^[6]

Related Research Articles

Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. It is in this form that HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB, and tumour metastasis. HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One study suggests that cellular heparan sulfate has a role in SARS-CoV-2 Infection, particularly when the virus attaches with ACE2.

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 1 is an enzyme that catalyzes the chemical reaction

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.

Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.

Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.

Exostosin-like 1 is a protein that in humans is encoded by the EXTL1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166507 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039308 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Humphries DE, Lanciotti J, Karlinsky JB (Jul 1998). "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2". Biochem J. 332 (2): 303–7. doi:10.1042/bj3320303. PMC 1219482 . PMID 9601056.
↑ "Entrez Gene: NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2".

Esko JD, Selleck SB (2002). "Order out of chaos: assembly of ligand binding sites in heparan sulfate". Annu. Rev. Biochem. 71: 435–71. doi:10.1146/annurev.biochem.71.110601.135458. PMID 12045103.
Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J. Biol. Chem. 274 (5): 2690–5. doi: 10.1074/jbc.274.5.2690 . PMID 9915799.
Forsberg E, Pejler G, Ringvall M, et al. (1999). "Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme". Nature. 400 (6746): 773–6. Bibcode:1999Natur.400..773F. doi:10.1038/23488. PMID 10466727. S2CID 4428529.
Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns". Biochemistry. 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2". Glycobiology. 13 (1): 1–10. doi: 10.1093/glycob/cwg011 . PMID 12634318.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Duncan MB, Liu M, Fox C, Liu J (2006). "Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2". Biochem. Biophys. Res. Commun. 339 (4): 1232–7. doi:10.1016/j.bbrc.2005.11.142. PMID 16343444.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166507 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039308 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9601056-5] Humphries DE, Lanciotti J, Karlinsky JB (Jul 1998). "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2". Biochem J. 332 (2): 303–7. doi:10.1042/bj3320303. PMC 1219482 . PMID 9601056.

[entrez-6] "Entrez Gene: NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2".

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NDST2

Related Research Articles

References

Further reading