NDST3

Last updated
NDST3
Identifiers
Aliases NDST3 , HSST3, N-deacetylase/N-sulfotransferase 3, N-deacetylase and N-sulfotransferase 3
External IDs OMIM: 603950; MGI: 1932544; HomoloGene: 3513; GeneCards: NDST3; OMA:NDST3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004784

NM_001293682
NM_031186

RefSeq (protein)

NP_004775

NP_001280611
NP_112463

Location (UCSC) Chr 4: 118.03 – 118.26 Mb Chr 3: 123.32 – 123.48 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. [5] [6] It catalyses the reaction:

Contents

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[ heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H+ + N-sulfo-α-D-glucosaminyl-[heparan sulfate](n) [7]

This is a step in the production of heparin. [7]

Clinical significance

Mutations in NDST3 have been linked to schizophrenia. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164100 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027977 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J Biol Chem. 274 (5): 2690–5. doi: 10.1074/jbc.274.5.2690 . PMID   9915799.
  6. "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".
  7. 1 2 "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". www.uniprot.org. Retrieved 2020-01-15.
  8. Zhang, C; Lu, W; Wang, Z; Ni, J; Zhang, J; Tang, W; Fang, Y (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese". Translational Psychiatry. 6 (1): e701. doi:10.1038/tp.2015.199. ISSN   2158-3188. PMC   5068873 . PMID   26731438.

Further reading