NDST3

NDST3
Identifiers
Aliases	NDST3 , HSST3, N-deacetylase/N-sulfotransferase 3, N-deacetylase and N-sulfotransferase 3
External IDs	OMIM: 603950 MGI: 1932544 HomoloGene: 3513 GeneCards: NDST3
Gene location (Human)
Chr.	Chromosome 4 (human)
End	118,258,634 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	123,690,853 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; putamen; ; cerebellar hemisphere; ; stomach; ; superior frontal gyrus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; corpus callosum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; sulfotransferase activity ; catalytic activity ; hydrolase activity ; [heparan sulfate-glucosamine N-sulfotransferase activity]; heparan sulfate N-acetylglucosaminyltransferase activity ; deacetylase activity ; heparan sulfate sulfotransferase activity ;
Cellular component	integral component of membrane ; Golgi membrane ; Golgi apparatus ; membrane ; cellular component ;
Biological process	metabolism ; heparin biosynthetic process ; heparan sulfate proteoglycan biosynthetic process ; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ; glycosaminoglycan biosynthetic process ; sulfur compound metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	9348
	83398
	ENSG00000164100
	ENSMUSG00000027977
	O95803
	Q9EQH7
	NM_004784
	NM_001293682 ; NM_031186
	NP_004775
	NP_001280611 ; NP_112463
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 24, 2021

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene.^[5]^[6] It catalyses the reaction:

Clinical significance

Mutations in NDST3 have been linked to schizophrenia.^[8]

Related Research Articles

Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. It is in this form that HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB, and tumour metastasis. HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One study suggests that cellular heparan sulfate has a role in SARS-CoV-2 Infection, particularly when the virus attaches with ACE2.

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 1 is an enzyme that catalyzes the chemical reaction

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 2 is an enzyme that catalyzes the chemical reaction

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

Galactose-3-O-sulfotransferase 4 is an enzyme that in humans is encoded by the GAL3ST4 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene. EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164100 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027977 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J Biol Chem. 274 (5): 2690–5. doi: 10.1074/jbc.274.5.2690 . PMID 9915799.
↑ "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".
1 2 "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". www.uniprot.org. Retrieved 2020-01-15.
↑ Zhang, C; Lu, W; Wang, Z; Ni, J; Zhang, J; Tang, W; Fang, Y (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese". Translational Psychiatry. 6 (1): e701. doi:10.1038/tp.2015.199. ISSN 2158-3188. PMC 5068873 . PMID 26731438.

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Aikawa J, Grobe K, Tsujimoto M, Esko JD (2001). "Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4". J. Biol. Chem. 276 (8): 5876–82. doi: 10.1074/jbc.M009606200 . PMID 11087757.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
Boutry M, Vassarotti A, Ghislain M, et al. (1984). "Isolation of the structural genes for the alpha and beta subunits of the mitochondrial ATPase from the fission yeast Schizosaccharomyces pombe". J. Biol. Chem. 259 (5): 2840–4. doi: 10.1016/S0021-9258(17)43223-6 . PMID 6230352.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164100 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027977 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9915799-5] Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J Biol Chem. 274 (5): 2690–5. doi: 10.1074/jbc.274.5.2690 . PMID 9915799.

[entrez-6] "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".

[:0-7] 1 2 "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". www.uniprot.org. Retrieved 2020-01-15.

[8] Zhang, C; Lu, W; Wang, Z; Ni, J; Zhang, J; Tang, W; Fang, Y (January 2016). "A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese". Translational Psychiatry. 6 (1): e701. doi:10.1038/tp.2015.199. ISSN 2158-3188. PMC 5068873 . PMID 26731438.

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NDST3

Contents

Clinical significance

Related Research Articles

References

Further reading