NDUFC1

NDUFC1
Identifiers
Aliases	NDUFC1 , KFYI, NADH:ubiquinone oxidoreductase subunit C1
External IDs	OMIM: 603844; MGI: 1913627; HomoloGene: 1865; GeneCards: NDUFC1; OMA:NDUFC1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q31.1 Start 139,266,880 bp [1] End 139,302,551 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 C Start 51,312,098 bp [2] End 51,316,409 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla right ventricle thoracic diaphragm Skeletal muscle tissue of rectus abdominis biceps brachii beta cell body of tongue Skeletal muscle tissue of biceps brachii kidney tubule vastus lateralis muscle Top expressed in muscle of thigh right kidney digastric muscle extraocular muscle sternocleidomastoid muscle myocardium of ventricle temporal muscle triceps brachii muscle right ventricle atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function NADH dehydrogenase (ubiquinone) activity Cellular component integral component of membrane mitochondrial inner membrane respirasome membrane mitochondrion mitochondrial respiratory chain complex I Biological process mitochondrial electron transport, NADH to ubiquinone mitochondrial respiratory chain complex I assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4717 66377 Ensembl ENSG00000109390 ENSMUSG00000037152 UniProt O43677 Q9CQY9 RefSeq (mRNA) NM_002494 NM_001184986 NM_001184987 NM_001184988 NM_001184989 NM_001184990 NM_001184991 NM_025523 RefSeq (protein) NP_001171915 NP_001171916 NP_001171917 NP_001171918 NP_001171919 NP_001171920 NP_002485 NP_079799 Location (UCSC) Chr 4: 139.27 – 139.3 Mb Chr 3: 51.31 – 51.32 Mb PubMed search [3] [4]
Wikidata
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NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial is an enzyme that in humans is encoded by the NDUFC1 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000109390 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037152 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ton C, Hwang DM, Dempsey AA, Liew CC (Jan 1998). "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits". Biochem Biophys Res Commun. 241 (2): 589–94. doi:10.1006/bbrc.1997.7707. PMID   9425316.
6. Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet. 82 (1–2): 115–9. doi:10.1159/000015082. PMID   9763677. S2CID   46818955.
7. "Entrez Gene: NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID   9878551.
• Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi: 10.1073/pnas.95.14.8175 . PMC   20949 . PMID   9653160.