NDUFC1

NDUFC1
Identifiers
Aliases	NDUFC1 , KFYI, NADH:ubiquinone oxidoreductase subunit C1
External IDs	OMIM: 603844 MGI: 1913627 HomoloGene: 1865 GeneCards: NDUFC1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	139,302,551 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	51,316,409 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; right ventricle; ; thoracic diaphragm; ; biceps brachii; ; body of tongue; ; kidney tubule; ; vastus lateralis muscle; ; retinal pigment epithelium; ; vena cava; ; triceps brachii muscle;
	Top expressed in
	digastric muscle; ; extraocular muscle; ; sternocleidomastoid muscle; ; myocardium of ventricle; ; temporal muscle; ; triceps brachii muscle; ; right ventricle; ; atrioventricular valve; ; thoracic diaphragm; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NADH dehydrogenase (ubiquinone) activity ;
Cellular component	integral component of membrane ; mitochondrial inner membrane ; respirasome ; membrane ; mitochondrion ; mitochondrial respiratory chain complex I ;
Biological process	mitochondrial electron transport, NADH to ubiquinone ; mitochondrial respiratory chain complex I assembly ;
	Sources:Amigo / QuickGO
Orthologs
	4717
	66377
	ENSG00000109390
	ENSMUSG00000037152
	O43677
	Q9CQY9
NM_002494 ; NM_001184986 ; NM_001184987 ; NM_001184988 ; NM_001184989 ;
	NM_001184990 ; NM_001184991
	NM_025523
NP_001171915 ; NP_001171916 ; NP_001171917 ; NP_001171918 ; NP_001171919 ;
	NP_001171920 ; NP_002485
	NP_079799
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial is an enzyme that in humans is encoded by the NDUFC1 gene.^[5]^[6]^[7]

Related Research Articles

NAD(P)H dehydrogenase, quinone 2, also known as QR2, is a protein that in humans is encoded by the NQO2 gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions of quinones. Its mechanism of reduction is through a ping-pong mechanism involving its FAD cofactor. Initially in a reductive phase NQO2 binds to reduced dihydronicotinamide riboside (NRH) electron donor, and mediates a hydride transfer from NRH to FAD. Then, in an oxidative phase, NQO2 binds to its quinone substrate and reduces the quinone to a dihydroquinone. Besides the two catalytic FAD, NQO2 also has two zinc ions. It is not clear whether the metal has a catalytic role. NQO2 is a paralog of NQO1

NQO2 is a homodimer. NQO2 can be inhibited by resveratrol. One of QR2's binding sites responds to 2-iodomelatonin, and has been referred to as MT₃.

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 is an enzyme that in humans is encoded by the NDUFA13 gene. The NDUFA13 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 is an enzyme that in humans is encoded by the NDUFA5 gene. The NDUFA5 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6, also known as complex I-B17, is a protein that in humans is encoded by the NDUFB6 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6, is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFV3 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 is a protein that in humans is encoded by the GNG5 gene.

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 is an enzyme that in humans is encoded by the NDUFA6 gene. The NDUFA6 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 is an enzyme that in humans is encoded by the NDUFB9 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9 is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain.

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 is a protein that in humans is encoded by the NDUFA2 gene. The NDUFA2 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Mutations in the NDUFA2 gene are associated with Leigh's syndrome.

NADH dehydrogenase [ubiquinone] 1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene.

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 is an enzyme that in humans is encoded by the NDUFA8 gene. The NDUFA8 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 is an enzyme that in humans is encoded by the NDUFS5 gene.

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 is an enzyme that in humans is encoded by the NDUFB1 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial is an enzyme that in humans is encoded by the NDUFB2 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, also known as complex I-B18, is an enzyme that in humans is encoded by the NDUFB7 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7 is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 is an enzyme that in humans is encoded by the NDUFB10 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10 is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain.

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial is an enzyme that in humans is encoded by the NDUFB11 gene. NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11 is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is also known as Complex I and is the largest of the five complexes of the electron transport chain. NDUFB11 mutations have been associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency.

In molecular biology, the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7 family of proteins form a part of NADH dehydrogenase. In mammals, it is encoded by the NDUFA7 gene.

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 is an enzyme that in humans is encoded by the NDUFA7 gene. The NDUFA7 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109390 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037152 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ton C, Hwang DM, Dempsey AA, Liew CC (Jan 1998). "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits". Biochem Biophys Res Commun. 241 (2): 589–94. doi:10.1006/bbrc.1997.7707. PMID 9425316.
↑ Emahazion T, Beskow A, Gyllensten U, Brookes AJ (Nov 1998). "Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain". Cytogenet Cell Genet. 82 (1–2): 115–9. doi:10.1159/000015082. PMID 9763677. S2CID 46818955.
↑ "Entrez Gene: NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa".

NDUFC1

Related Research Articles

References

Further reading