NDUFC2

NDUFC2
Identifiers
Aliases	NDUFC2 , B14.5b, CI-B14.5b, HLC-1, NADHDH2, NADH:ubiquinone oxidoreductase subunit C2, MC1DN36
External IDs	OMIM: 603845; MGI: 1344370; HomoloGene: 3344; GeneCards: NDUFC2; OMA:NDUFC2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q14.1 Start 78,068,297 bp [1] End 78,079,862 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E1 Start 97,049,210 bp [2] End 97,057,009 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal cortex right adrenal cortex muscle of thigh mucosa of transverse colon olfactory zone of nasal mucosa buccal mucosa cell right lobe of thyroid gland left lobe of thyroid gland ganglionic eminence Top expressed in facial motor nucleus atrioventricular valve endocardial cushion medial ganglionic eminence anterior horn of spinal cord intercostal muscle digastric muscle brown adipose tissue lobe of cerebellum mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function NADH dehydrogenase (ubiquinone) activity Cellular component cytoplasm integral component of membrane mitochondrial inner membrane mitochondrial respiratory chain complex I respirasome membrane mitochondrion plasma membrane azurophil granule membrane Biological process mitochondrial electron transport, NADH to ubiquinone neutrophil degranulation mitochondrial respiratory chain complex I assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4718 68197 Ensembl ENSG00000151366 ENSMUSG00000030647 UniProt O95298 Q9CQ54 RefSeq (mRNA) NM_004549 NM_001204054 NM_001204055 NM_024220 RefSeq (protein) NP_001190983 NP_001190984 NP_004540 NP_077182 Location (UCSC) Chr 11: 78.07 – 78.08 Mb Chr 7: 97.05 – 97.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NADH dehydrogenase [ubiquinone] 1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene. ^{[5] [6]}

The NDUF2 gene encodes one of the subunits of complex I, the first and largest complex of the mitochondrial respiratory chain. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000151366 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030647 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Loeffen JL, Triepels RH, van den Heuvel LP, Schuelke M, Buskens CA, Smeets RJ, Trijbels JM, Smeitink JA (Jan 1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem Biophys Res Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID   9878551.
6. "Entrez Gene: NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa".

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.