NEK3

NEK3
Identifiers
Aliases	NEK3 , HSPK36, NIMA related kinase 3
External IDs	OMIM: 604044; MGI: 1344371; HomoloGene: 1869; GeneCards: NEK3; OMA:NEK3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.3 Start 52,132,639 bp [1] End 52,159,861 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 A2|8 11.07 cM Start 22,618,299 bp [2] End 22,656,451 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gonad mucosa of transverse colon testicle right testis left testis C1 segment rectum corpus callosum Achilles tendon Top expressed in fossa medullary collecting duct trigeminal ganglion facial motor nucleus superior cervical ganglion urothelium condyle renal corpuscle transitional epithelium of urinary bladder lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding protein kinase activity protein binding kinase activity metal ion binding nucleotide binding transferase activity protein serine/threonine kinase activity Cellular component cell projection axon nucleus cytoplasm Biological process establishment of cell polarity cell cycle phosphorylation cell division neuron projection morphogenesis regulation of tubulin deacetylation protein phosphorylation mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4752 23954 Ensembl ENSG00000136098 ENSMUSG00000031478 UniProt P51956 Q9R0A5 RefSeq (mRNA) NM_001146099 NM_002498 NM_152720 NM_001162947 NM_011848 RefSeq (protein) NP_001139571 NP_002489 NP_689933 NP_001156419 NP_035978 Location (UCSC) Chr 13: 52.13 – 52.16 Mb Chr 8: 22.62 – 22.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase Nek3 is an enzyme that in humans is encoded by the NEK3 gene. ^{[5] [6] [7]}

In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000136098 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031478 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schultz SJ, Nigg EA (Feb 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID   8274451.
6. Schultz SJ, Fry AM, Sutterlin C, Ried T, Nigg EA (Oct 1994). "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans". Cell Growth Differ. 5 (6): 625–35. PMID   7522034.
7. "Entrez Gene: NEK3 NIMA (never in mitosis gene a)-related kinase 3".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Tanaka K, Nigg EA (1999). "Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators". J. Biol. Chem. 274 (19): 13491–7. doi: 10.1074/jbc.274.19.13491 . PMID   10224116.
• Kimura M, Okano Y (2002). "Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3)". Cytogenet. Cell Genet. 95 (3–4): 177–82. doi:10.1159/000059342. PMID   12063396. S2CID   25785949.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Miller SL, DeMaria JE, Freier DO, et al. (2005). "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor". Mol. Endocrinol. 19 (4): 939–49. doi: 10.1210/me.2004-0443 . PMID   15618286.
• Hernández M, Almeida TA (2007). "Is there any association between nek3 and cancers with frequent 13q14 deletion?". Cancer Invest. 24 (7): 682–8. doi:10.1080/07357900600981364. PMID   17118778. S2CID   33072654.
• Miller SL, Antico G, Raghunath PN, et al. (2007). "Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells". Oncogene. 26 (32): 4668–78. doi: 10.1038/sj.onc.1210264 . PMID   17297458.