NUDT9

NUDT9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q33, 1QVJ
Identifiers
Aliases	NUDT9 , NUDT10, nudix hydrolase 9
External IDs	OMIM: 606022; MGI: 1921417; HomoloGene: 11435; GeneCards: NUDT9; OMA:NUDT9 - orthologs
Gene location (Mouse) Chr. Chromosome 5 (mouse) [1] Band 5|5 E5 Start 104,194,172 bp [1] End 104,213,245 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans body of pancreas middle temporal gyrus duodenum parotid gland right adrenal gland rectum jejunal mucosa left adrenal gland glomerulus Top expressed in saccule otic placode otic vesicle vestibular membrane of cochlear duct seminiferous tubule fetal liver hematopoietic progenitor cell sciatic nerve interventricular septum extensor digitorum longus muscle plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity ADP-ribose diphosphatase activity ADP-sugar diphosphatase activity adenosine-diphosphatase activity Cellular component mitochondrial matrix intracellular anatomical structure extracellular exosome mitochondrion cell junction nuclear membrane Biological process nucleobase-containing small molecule catabolic process IDP catabolic process ADP catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53343 74167 Ensembl n/a ENSMUSG00000029310 UniProt Q9BW91 Q8BVU5 RefSeq (mRNA) NM_001248011 NM_024047 NM_198038 NM_028794 RefSeq (protein) NP_001234940 NP_076952 NP_932155 NP_083070 Location (UCSC) n/a Chr 5: 104.19 – 104.21 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene. ^{[4] [5] [6]}

References

1. GRCm38: Ensembl release 89: ENSMUSG00000029310 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (May 2001). "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology". Nature. 411 (6837): 595–9. Bibcode:2001Natur.411..595P. doi:10.1038/35079100. PMID   11385575. S2CID   4338852.
5. Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM (Jan 2003). "NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase". J Biol Chem. 278 (3): 1794–801. doi: 10.1074/jbc.M205601200 . PMID   12427752.
6. "Entrez Gene: NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9".

Further reading

• Lin S, Gasmi L, Xie Y, et al. (2002). "Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose)". Biochim. Biophys. Acta. 1594 (1): 127–35. doi:10.1016/S0167-4838(01)00296-5. PMID   11825615.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang HT, Yan ZQ, Hu XB, et al. (2004). "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 35 (8): 747–51. PMID   12897971.
• Shen BW, Perraud AL, Scharenberg A, Stoddard BL (2003). "The crystal structure and mutational analysis of human NUDT9". J. Mol. Biol. 332 (2): 385–98. doi:10.1016/S0022-2836(03)00954-9. PMID   12948489.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Carloto A, Costas MJ, Cameselle JC, et al. (2006). "The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2". Biochim. Biophys. Acta. 1760 (10): 1545–51. doi:10.1016/j.bbagen.2006.06.003. PMID   16860484.