Narasin

Last updated
Narasin
Narasin.png
Clinical data
Other names(4S)-4-methyl-salinomycin
AHFS/Drugs.com International Drug Names
ATCvet code
Identifiers
  • (2R)-2-[(2R,3S,5S,6R)-6-[(1S,2S,3S,5R)-5- [(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyl-2-tetrahydropyranyl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]-3,5-dimethyl-2-tetrahydropyranyl]butanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.122.892 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C43H72O11
Molar mass 765.038 g·mol−1
3D model (JSmol)
  • O=C([C@@H](C)[C@@H](O)[C@H](C)[C@]5([H])O[C@]([C@@H](CC)C(O)=O)([H])[C@@H](C)C[C@@H]5C)[C@H](CC)[C@@]1([H])O[C@@]2(O[C@@]3(CC[C@]([C@]4([H])O[C@@H](C)[C@@](O)(CC)CC4)(C)O3)[C@H](O)C=C2)[C@H](C)C[C@@H]1C
  • InChI=1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1
  • Key:VHKXXVVRRDYCIK-CWCPJSEDSA-N
   (verify)

Narasin is a coccidiostat and antibacterial agent. [1] [2] It is a derivative of salinomycin with an additional methyl group. Narasin is produced by fermentation of a strain of Streptomyces aureofaciens . [3]

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References

  1. Gerhold RW, Fuller AL, Lollis L, Parr C, McDougald LR (March 2011). "The efficacy of anticoccidial products against Eimeria spp. in northern bobwhites". Avian Diseases. 55 (1): 59–64. doi:10.1637/9572-101310-Reg.1. PMID   21500637. S2CID   30943649.
  2. Fitzgerald PR, Mansfield ME (July 1989). "Effects of inoculations with Eimeria zuernii on young calves treated with decoquinate or narasin with or without dexamethasone". American Journal of Veterinary Research. 50 (7): 1056–1059. PMID   2774323.
  3. Anadón A, Martínez-Larrañaga MR (2014). "Veterinary Drugs Residues: Coccidiostats". Encyclopedia of Food Safety. pp. 63–75. doi:10.1016/B978-0-12-378612-8.00246-8. ISBN   9780123786135.