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The Ness Foundation was a research charity based near Inverness, Scotland. It was active from 1999 and was a constituent partner of the University of the Highlands and Islands (UHI) until the foundation became insolvent and by 2008 and parts were then acquired by UHI.
The Highland Psychiatric Research Group had been founded in the 1980s with the involvement of Iain Glen, a consultant psychiatrist. [1] [2] Glen had an interest in cell membrane biochemistry, and theorised that there was a relationship to a group of mental health disorders. [2] [3]
The Ness Foundation was registered as a charity in 1998 [4] and the following year became an associate partner of the project that went on to become the UHI Millenium Institute. [5] Between 2001 and 2004 the Foundation was run by Dr. Brian M. Ross during which time the Foundation received support from the European Regional Development Fund and various other private and public partners. The ties between the University and the Ness Foundation grew closer with the Foundation contributing significantly to the total research output and income of UHI. It was involved with carrying out research into diagnosing conditions such as schizophrenia, bipolar disorder, autism spectrum disorder, developmental coordination disorder, dyslexia, depression and attention-deficit/hyperactivity disorder. [5] Its principal area of research was the relevance of lipids in these disorders but later this has been extended to include the role of genetics.
Through its wholly owned commercial subsidiary, Pan Diagnostics Limited, the foundation worked to develop a tool kit intended to enable early detection of people at a higher risk of serious mental illness. The kit consisting of a skin patch, breath test (measuring how a person's body breaks down Omega-3 fatty acid) and if these were positive a genetic test was also run. [6]
The foundation was a constituent partner of UHI when it became insolvent and by 2008 parts had been absorbed into UHI. [7] [8]
A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is also characterized by a clinically significant disturbance in an individual's cognition, emotional regulation, or behavior, often in a social context. Such disturbances may occur as single episodes, may be persistent, or may be relapsing–remitting. There are many different types of mental disorders, with signs and symptoms that vary widely between specific disorders. A mental disorder is one aspect of mental health.
Schizophrenia is a mental disorder characterized by hallucinations, delusions, disorganized thinking and behavior, and flat or inappropriate affect. Symptoms develop gradually and typically begin during young adulthood and are never resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a psychiatric history that includes the person's reported experiences, and reports of others familiar with the person. For a diagnosis of schizophrenia, the described symptoms need to have been present for at least six months or one month. Many people with schizophrenia have other mental disorders, especially depressive disorder, anxiety disorders, and obsessive–compulsive disorder.
Schizoaffective disorder is a mental disorder characterized by abnormal thought processes and an unstable mood. This diagnosis requires symptoms of both schizophrenia (psychosis) and a mood disorder: either bipolar disorder or depression. The main criterion is the presence of psychotic symptoms for at least two weeks without any mood symptoms. Schizoaffective disorder can often be misdiagnosed when the correct diagnosis may be psychotic depression, bipolar I disorder, schizophreniform disorder, or schizophrenia. This is a problem as treatment and prognosis differ greatly for most of these diagnoses. Many people with schizoaffective disorder have other mental disorders including anxiety disorders.
Ronald David Laing, usually cited as R. D. Laing, was a Scottish psychiatrist who wrote extensively on mental illness—in particular, psychosis and schizophrenia. Laing's views on the causes and treatment of psychopathological phenomena were influenced by his study of existential philosophy and ran counter to the chemical and electroshock methods that had become psychiatric orthodoxy. Laing took the expressed feelings of the individual patient or client as valid descriptions of personal experience rather than simply as symptoms of mental illness. Though associated in the public mind with the anti-psychiatry movement, he rejected the label. Laing regarded schizophrenia as the normal psychological adjustment to a dysfunctional social context, although later in life he revised his views.
Biological psychiatry or biopsychiatry is an approach to psychiatry that aims to understand mental disorder in terms of the biological function of the nervous system. It is interdisciplinary in its approach and draws on sciences such as neuroscience, psychopharmacology, biochemistry, genetics, epigenetics and physiology to investigate the biological bases of behavior and psychopathology. Biopsychiatry is the branch of medicine which deals with the study of the biological function of the nervous system in mental disorders.
The Institute of Psychiatry, Psychology & Neuroscience (IoPPN) is a centre for mental health and neuroscience research, education and training in Europe. It is dedicated to understanding, preventing and treating mental illness, neurological conditions, and other conditions that affect the brain. The IoPPN is a faculty of King's College London, England, and was previously known as the Institute of Psychiatry (IoP).
Professor Christos Pantelis is an Australian professor of medicine who is the Director of the Melbourne Neuropsychiatry Centre.
Rethink Mental Illness Is a British charity that seeks to improve the lives of people severely affected by mental illness through their networks of local groups and services, information and campaigns. Its stated goal is to make sure everyone severely affected by mental illness has a good quality of life.
The biopsychiatry controversy is a dispute over which viewpoint should predominate and form a basis of psychiatric theory and practice. The debate is a criticism of a claimed strict biological view of psychiatric thinking. Its critics include disparate groups such as the antipsychiatry movement and some academics.
Peter McGuffin was a Northern Irish psychiatrist and geneticist from Belfast.
The Brain & Behavior Research Foundation (BBRF) is a nonprofit 501(c)(3) organization that funds mental health research. It was originally called the National Alliance for Research on Schizophrenia & Depression, or NARSAD. It received its nonprofit ruling in 1981.
Irving Isadore Gottesman was an American professor of psychology who devoted most of his career to the study of the genetics of schizophrenia. He wrote 17 books and more than 290 other publications, mostly on schizophrenia and behavioral genetics, and created the first academic program on behavioral genetics in the United States. He won awards such as the Hofheimer Prize for Research, the highest award from the American Psychiatric Association for psychiatric research. Lastly, Gottesman was a professor in the psychology department at the University of Minnesota, where he received his Ph.D.
Childhood schizophrenia is similar in characteristics of schizophrenia that develops at a later age, but has an onset before the age of 13 years, and is more difficult to diagnose. Schizophrenia is characterized by positive symptoms that can include hallucinations, delusions, and disorganized speech; negative symptoms, such as blunted affect and avolition and apathy, and a number of cognitive impairments. Differential diagnosis is problematic since several other neurodevelopmental disorders, including autism spectrum disorder, language disorder, and attention deficit hyperactivity disorder, also have signs and symptoms similar to childhood-onset schizophrenia.
The diagnosis of schizophrenia, a psychotic disorder, is based on criteria in either the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, or the World Health Organization's International Classification of Diseases (ICD). Clinical assessment of schizophrenia is carried out by a mental health professional based on observed behavior, reported experiences, and reports of others familiar with the person. Diagnosis is usually made by a psychiatrist. Associated symptoms occur along a continuum in the population and must reach a certain severity and level of impairment before a diagnosis is made. Schizophrenia has a prevalence rate of 0.3-0.7% in the United States.
The Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard is a multi-disciplinary biomedical research program located in Cambridge, Massachusetts that studies the biological basis of psychiatric disease.
The Lieber Institute for Brain Development (LIBD) is a nonprofit research center located in Baltimore, Maryland, that studies brain development issues such as schizophrenia and autism. The cause of most neuropsychiatric disorders remains unknown and current therapies such as antipsychotics and antidepressants treat symptoms rather than the underlying illness. Lieber is working to unravel the biological basis of these brain disorders and is developing therapies to treat or prevent their development.
Benjamin Michael Neale is a statistical geneticist with a specialty in psychiatric genetics. He is an institute member at the Broad Institute as well as an associate professor at both Harvard Medical School and the Analytic and Translational Genetics Unit at Massachusetts General Hospital. Neale specializes in genome-wide association studies (GWAS). He was responsible for the data analysis of the first GWAS on attention-deficit/hyperactivity-disorder, and he developed new analysis software such as PLINK, which allows for whole-genome data to be analyzed for specific gene markers. Related to his work on GWAS, Neale is the lead of the ADHD psychiatric genetics and also a member of the Psychiatric GWAS Consortium analysis committee.
Ming Tso Tsuang is an American psychiatrist and Distinguished Professor of Psychiatry at the University of California, San Diego. He is considered a pioneering researcher in the genetic epidemiology of schizophrenia and other severe mental disorders. Tsuang has authored and co-authored more than 600 publications and serves as founding and senior editor of the American Journal of Medical Genetics Part B.
Michael C. O'Donovan is a Scottish psychiatric geneticist who researches the genetics of schizophrenia. He is a clinical professor in the Division of Psychological Medicine and Clinical Neurosciences and the deputy director of the MRC Centre for Neuropsychiatric Genetics and Genomics at the Cardiff University School of Medicine in Cardiff, Wales. He also leads the Schizophrenia Group of the Psychiatric Genomics Consortium. Educated at Glasgow University, he also serves as Academic Psychiatry Lead for the Royal College of Psychiatrists in Wales. He was lead author of a 2014 study in Nature which identified over 100 genetic loci associated with an increased risk of schizophrenia. The study, the largest of its kind undertaken at the time, was covered extensively in the media. It was also praised by Thomas Insel, the then-director of the National Institute of Mental Health, who described the study as "a big step forward".
Thara Rangaswamy is a psychiatrist in India, the co-founder of an NGO called SCARF based in Chennai, India. She is a researcher in schizophrenia and community mental health. In 2020, she received the SIRS Outstanding Clinical and Community Research Award of SIRS, an apex body for work on schizophrenia in Florence, Italy.
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