Nfat activating protein with itam motif 1

NFAM1
Identifiers
Aliases	NFAM1 , CNAIP, bK126B4.4, NFAT activating protein with ITAM motif 1
External IDs	OMIM: 608740 MGI: 1921289 HomoloGene: 12528 GeneCards: NFAM1
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.2 Start 42,380,407 bp [1] End 42,432,403 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 82,992,973 bp [2] End 83,033,306 bp [2]
Gene ontology Molecular function • transmembrane signaling receptor activity Cellular component • integral component of membrane • membrane • cell membrane • azurophil granule membrane Biological process • positive regulation of B cell receptor signaling pathway • cell surface receptor signaling pathway • positive regulation of sequence-specific DNA binding transcription factor activity • GO:0007243 intracellular signal transduction • inflammatory response • regulation of B cell differentiation • signal transduction • positive regulation of cytokine production • neutrophil degranulation • B cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	150372	74039
Ensembl	ENSG00000235568	ENSMUSG00000058099
UniProt	Q8NET5	Q8R4V1
RefSeq (mRNA)	NM_145912 NM_001318323 NM_001371362	NM_001271411 NM_001271412 NM_001271413 NM_001271414 NM_028728
RefSeq (protein)	NP_001305252 NP_666017 NP_001358291	NP_001258340 NP_001258341 NP_001258342 NP_001258343 NP_083004
Location (UCSC)	Chr 22: 42.38 – 42.43 Mb	Chr 15: 82.99 – 83.03 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

NFAT activating protein with ITAM motif 1 is a protein that in humans is encoded by the NFAM1 gene. ^[5]

Function

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000235568 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058099 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NFAT activating protein with ITAM motif 1" . Retrieved 2018-03-13.

Further reading

• Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z (May 2003). "Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway". J. Biol. Chem. 278 (19): 16797–801. doi: 10.1074/jbc.M211060200 . PMID   12615919.
• Nilsson LM, Sun ZW, Nilsson J, Nordström I, Chen YW, Molkentin JD, Wide-Swensson D, Hellstrand P, Lydrup ML, Gomez MF (March 2007). "Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation" (PDF). Am. J. Physiol., Cell Physiol. 292 (3): C1167–78. doi:10.1152/ajpcell.00590.2005. PMID   17079331.
• Manley K, O'Hara BA, Atwood WJ (March 2008). "Nuclear factor of activated T-cells (NFAT) plays a role in SV40 infection". Virology. 372 (1): 48–55. doi:10.1016/j.virol.2007.10.029. PMC   2289909 . PMID   18031784.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.