Nick Hoogenraad | |
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Born | Nicolaas Johannes Hoogenraad |
Alma mater | University of Melbourne |
Children | 2 |
Awards | ASBMB Lemberg Medal AMRAD/Pharmacia Biotechnology Medal Leach Protein Chemistry Medal Officer of the Order of Australia Charles La Trobe Distinguished Chair in Biochemistry |
Scientific career | |
Fields | Agricultural biochemistry Medical biochemistry Mitochondrial biochemistry |
Institutions | University of Melbourne Stanford University La Trobe University |
Thesis | Studies on the Contribution of Rumen Bacteria to the Nutritional Requirements of Sheep (1969) |
Doctoral advisor | Frank Hird |
Website | https://scholars.latrobe.edu.au/njhoogenraad |
Professor Nick Hoogenraad, AO is an Australian biochemist. [1] He is currently Emeritus Professor of Biochemistry at La Trobe University. [2] Hoogenraad's work led to the discovery of the mitochondrial unfolded protein response. [3]
Hoogenraad completed a bachelor of agricultural science, by the end of which time he had "fallen in love with biochemistry", partly due to reading The Origin of Life by Soviet biochemist Alexander Oparin. [4] He completed his Ph.D. under agricultural biochemist Frank Hird, using biochemical and electron microscopy techniques to compile the first atlas of the bacteria in the rumen of sheep. Working with the rumen bacteria was unpleasant and another member of Hird's lab, Max Marginson, started calling Hoogenraad "rumencrud" in allusion to this. This behaviour stopped after Hoogenraad placed some foul-smelling butyric acid on Marginson's jacket. [4]
He began work as a postdoctoral researcher in the Pediatric department at Stanford University in 1969, becoming Assistant Professor in Human Biology in 1971, and returning for a year as visiting professor in 1979. He returned to Australia in 1974 after being hired by Bruce Stone to join the new department of Biochemistry at La Trobe University. He became Head of Biochemistry when Stone retired in 1993. In 1998 he was appointed Head of the School of Molecular Sciences [4] which was restructured multiple times, and by his retirement in 2014 contained three departments: Biochemistry and Genetics, Chemistry and Physics, and Pharmacy and Applied Science. [5] Hoogenraad also served as the founding director of the La Trobe Institute for Molecular Science from 2009 to 2014. [6] An auditorium in the LIMS1 building is named after him. [5] His latest research interest is cachexia. [7]
Allan Charles Wilson FRS AAA&S was a professor of biochemistry at the University of California, Berkeley, a pioneer in the use of molecular approaches to understand evolutionary change and reconstruct phylogenies, and a revolutionary contributor to the study of human evolution. He was one of the most significant figures in post-war biology; his work attracted a great deal of attention both from within and outside the academic world. He is the only New Zealander to have won the MacArthur Fellowship.
Hartmut Michel is a German biochemist, who received the 1988 Nobel Prize in Chemistry for determination of the first crystal structure of an integral membrane protein, a membrane-bound complex of proteins and co-factors that is essential to photosynthesis.
Peter Walter is a German-American molecular biologist and biochemist. He is currently the Director of the Bay Area Institute of Science at Altos Labs and an emeritus professor at the Department of Biochemistry and Biophysics of the University of California, San Francisco (UCSF). He was a Howard Hughes Medical Institute (HHMI) Investigator until 2022.
Gregory A. Petsko is an American biochemist and member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. He is currently Professor of Neurology at the Ann Romney Center for Neurologic Diseases at Harvard Medical School and Brigham and Women's Hospital. He formerly had an endowed professorship in Neurology and Neuroscience at Weill Cornell Medical College and is still an adjunct professor of Biomedical Engineering at Cornell University, and is also the Gyula and Katica Tauber Professor, Emeritus, in biochemistry and chemistry at Brandeis University. On October 24, 2023, in a ceremony in the East Room of the White House, President Joe Biden presented Gregory Petsko and eight others with the National Medal of Science, the highest honor the United States can bestow on a scientist and engineer.
Irwin Fridovich was an American biochemist who, together with his graduate student Joe M. McCord, discovered the enzymatic activity of copper-zinc superoxide dismutase (SOD),—to protect organisms from the toxic effects of superoxide free radicals formed as a byproduct of normal oxygen metabolism. Subsequently, Fridovich's research group also discovered the manganese-containing and the iron-containing SODs from Escherichia coli and the mitochondrial MnSOD (SOD2), now known to be an essential protein in mammals. He spent the rest of his career studying the biochemical mechanisms of SOD and of biological superoxide toxicity, using bacteria as model systems. Fridovich was also Professor Emeritus of Biochemistry at Duke University.
Franz-Ulrich Hartl is a German biochemist and the current Executive Director of the Max Planck Institute of Biochemistry. He is known for his pioneering work in chaperone-mediated protein folding.
Steven G. Clarke, an American biochemist, is a director of the UCLA Molecular Biology Institute, a professor of chemistry and biochemistry at UCLA biochemistry department. Clarke heads a laboratory at UCLA's department of chemistry and biochemistry. Clarke is famous for his work on molecular damage and discoveries of novel molecular repair mechanisms.
Charles Tanford was a German-born protein biochemist. He died in York, England, on October 1, 2009.
Leann Tilley is Professor of Biochemistry and Molecular Biology in the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne.
The La Trobe Institute for Molecular Science (LIMS) is an Australian institute based at La Trobe University in Melbourne. It contains research groups in life sciences, physical sciences, and applied sciences (pharmacy) and teaches undergraduate and graduate courses in these areas through the School of Molecular Sciences. Established in 2009, the institute has been led by Professor Andrew Hill since 2017.
Peter Bordier Høj is a Danish-Australian academic and Vice-Chancellor and President of the University of Adelaide. Peter Høj is one of the longest serving Australian Vice-Chancellors having served for 16 years across three universities. He has previously served as Vice-Chancellor and President of the University of Queensland and the University of South Australia. Educated at the University of Copenhagen, Høj completed a Bachelor of Science where he majored in biochemistry and chemistry, a Master of Science in biochemistry and genetics and a Doctor of Philosophy in Photosynthesis. He has worked in Denmark and Australia as a researcher and published multiple scientific articles. Høj has also served on a number of different company boards in a variety of roles, including current roles on the boards of CSIRO, Wine Australia and of the Australian Cancer Research Foundation. In 2017 he was elected chair of the Group of Eight, a lobby group that represents Australia’s research-intensive universities. He was the vice-chancellor of the University of Queensland from 2012-2020.
The mitochondrial unfolded protein response (UPRmt) is a cellular stress response related to the mitochondria. The UPRmt results from unfolded or misfolded proteins in mitochondria beyond the capacity of chaperone proteins to handle them. The UPRmt can occur either in the mitochondrial matrix or in the mitochondrial inner membrane. In the UPRmt, the mitochondrion will either upregulate chaperone proteins or invoke proteases to degrade proteins that fail to fold properly. UPRmt causes the sirtuin SIRT3 to activate antioxidant enzymes and mitophagy.
Tracy Palmer is a professor of microbiology in the Biosciences Institute at Newcastle University in Tyne & Wear, England. She is known for her work on the twin-arginine translocation (Tat) pathway.
Lynn Dalgarno is an Australian geneticist known for the discovery of the Shine-Dalgarno sequence with his graduate student, John Shine.
Casper Hoogenraad is a Dutch Cell Biologist who specializes in molecular neuroscience. The focus of his research is the basic molecular and cellular mechanisms that regulate the development and function of the brain. As of January 2020, he serves as Vice President of Neuroscience at Genentech Research and Early Development.
Alan Lambowitz is a professor for the University of Texas at Austin in Molecular Biosciences and Oncology and has been instrumental in many bio-molecular processes and concepts, such as intron splicing and mitochondrial ribosomal assembly.
Eilika Weber-Ban is a German biochemist. Her research considers protein degradation pathways. She was elected to the European Molecular Biology Organization in 2021.
Bruce Arthur Stone AM was an Australian biochemist and the foundation Professor of Biochemistry at La Trobe University.
Francis John Raymond Hird, better known as Frank Hird or, in print, F. J. R. Hird, was an Australian agricultural biochemist. He was the third head of the Department of Biochemistry at the University of Melbourne (1968–1974).
Marietta Tuena Sangri , was a Mexican physician, professor, biochemist and researcher. She is a member of the National System of Researchers.