U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini. It reaches its northernmost point at Elizabethton, Tennessee. Because of its unusual "north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each state: An alternate route to interstates in South Carolina, a major highway in North Carolina, and a scenic route in Tennessee.
North Carolina Highway 615 (NC 615) is a primary state highway in the U.S. state of North Carolina. It connects Knotts Island with mainland North Carolina via the Currituck–Knotts Island Ferry.
North Carolina Highway 82 (NC 82) is a primary state highway in the U.S. state of North Carolina. The highway traverses where the Battle of Averasborough took place and connects the towns of Erwin, Godwin and Falcon. Though the road is signed as east and west, it runs physically north from Erwin to US 13 to the south near Cooper.
North Carolina Highway 150 (NC 150) is a primary state highway in the U.S. state of North Carolina. It serves the Foothills and Piedmont Triad areas of the state, connecting the cities of Shelby, Mooresville, Salisbury and Winston-Salem.
North Carolina Highway 10 (NC 10) is a primary state highway in the U.S. state of North Carolina. Originally established as the state's central highway, from Murphy to Beaufort. Nowadays, it serves to connect the city of Newton with the nearby communities and towns in the foothills region.
North Carolina Highway 87 (NC 87) is a primary state highway in the U.S. state of North Carolina. NC 87 begins in the Atlantic coastal town of Southport and crosses into Virginia at the Virginia state line five miles (8 km) north of Eden in Rockingham County. At 240 miles (390 km) in length, NC 87 is the second longest state highway in the U.S. state of North Carolina. Labeled as a north–south route, NC 87 travels along a relatively straight southeast–northwest path, connecting Cape Fear region with the Piedmont and connecting the cities of Fayetteville, Sanford, and Burlington.
North Carolina Highway 101 (NC 101) is a primary state highway in the U.S. state of North Carolina that serves as a shortcut for U.S. Route 70 (US 70). It links Havelock to Beaufort, bypassing Morehead City. Most of the area along NC 101 is rural with many farms and swamps.
North Carolina Highway 46 (NC 46) is a primary state highway in the U.S. state of North Carolina; it is entirely in Northampton County. The route primarily connects the communities on the north side of Roanoke Rapids Lake and Lake Gaston, as well as the north side of the Roanoke River in the county.
North Carolina Highway 119 (NC 119) is a primary state highway in the U.S. state of North Carolina.
North Carolina Highway 62 (NC 62) is a primary state highway in the U.S. state of North Carolina. Primarily in the Piedmont Triad, it runs from NC 109 in Thomasville northeast to the Virginia state line in Milton.
North Carolina Highway 903 (NC 903) is a primary state highway in the U.S. state of North Carolina. It serves as predominantly rural highway in the Inner Banks region and arterial road in and around Greenville. The road covers a total of 200 miles (320 km), in a zigzag pattern through the state.
North Carolina Highway 242 (NC 242) is a primary state highway in the U.S. state of North Carolina. It traverses from Cerro Gordo to Benson, connecting the cities of Bladenboro, Elizabethtown, and Roseboro.
North Carolina Highway 306 (NC 306) is a primary state highway in the U.S. state of North Carolina. The highway provides a link between Havelock, Minnesott Beach, and Grantsboro. The route is primarily rural, and uses two free ferries to cross the Neuse and Pamlico Rivers before reaching NC 92/NC 99 near Gaylord.
North Carolina Highway 181 (NC 181) is a primary state highway in the U.S. state of North Carolina. It runs north–south from Morganton to Newland.
North Carolina Highway 93 (NC 93) is a primary state highway in the U.S. state of North Carolina. It runs from the Virginia state line to the community of Twin Oaks, entirely in Alleghany County.
North Carolina Highway 217 (NC 217) is a primary state highway in the U.S. state of North Carolina. The highway connects the town of Linden to nearby Erwin to Fayetteville.
North Carolina Highway 308 (NC 308) is a primary state highway in the U.S. state of North Carolina. It serves mainly to connect the city of Windsor to communities and towns in eastern Bertie County.
