OBSL1

OBSL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CPC, 2E6P, 2E6Q, 2LU7, 2LVC, 2WP3, 2WWK, 2WWM, 3KNB
Identifiers
Aliases	OBSL1 , obscurin like 1, obscurin like cytoskeletal adaptor 1
External IDs	OMIM: 610991; MGI: 2138628; HomoloGene: 28013; GeneCards: OBSL1; OMA:OBSL1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q35 Start 219,550,728 bp [1] End 219,571,859 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C4 Start 75,455,954 bp [2] End 75,483,096 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis left ovary right ovary right lobe of thyroid gland left lobe of thyroid gland right adrenal cortex right uterine tube apex of heart right hemisphere of cerebellum Top expressed in yolk sac internal carotid artery external carotid artery fossa muscle of thigh condyle vas deferens renal corpuscle genital tubercle medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal anchor activity protein binding structural constituent of muscle actin filament binding muscle alpha-actinin binding structural molecule activity conferring elasticity Cellular component Z discdkac 3M complex intercalated disc M band centrosome microtubule organizing center cytoskeleton cytoplasm Golgi apparatus perinuclear region of cytoplasm muscle myosin complex cytosol striated muscle thin filament sarcomere Biological process protein localization to Golgi apparatus cardiac myofibril assembly microtubule cytoskeleton organization cytoskeleton organization regulation of mitotic nuclear division positive regulation of dendrite morphogenesis Golgi organization striated muscle contraction actin filament organization sarcomere organization striated muscle myosin thick filament assembly post-translational protein modification muscle contraction skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly cardiac muscle tissue morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23363 98733 Ensembl ENSG00000124006 ENSMUSG00000026211 UniProt O75147 D3YYU8 RefSeq (mRNA) NM_001173408 NM_001173431 NM_015311 NM_178884 NM_001310679 RefSeq (protein) NP_001166879 NP_001166902 NP_056126 NP_001297608 NP_849215 NP_001390042 NP_001390043 Location (UCSC) Chr 2: 219.55 – 219.57 Mb Chr 1: 75.46 – 75.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Obscurin-like protein 1 is a protein that in humans is encoded by the OBSL1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000124006 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026211 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
6. "Entrez Gene: OBSL1 obscurin-like 1".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Geisler SB, Robinson D, Hauringa M, et al. (2007). "Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin". Genomics. 89 (4): 521–31. doi:10.1016/j.ygeno.2006.12.004. PMC   1885211 . PMID   17289344.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.

External links

• GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
• OMIM entries on 3-M syndrome
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Obscurin-like protein 1 (OBSL1)