OXSR1

OXSR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2V3S, 2VWI, 3DAK
Identifiers
Aliases	OXSR1 , OSR1, oxidative stress responsive 1, oxidative stress responsive kinase 1
External IDs	OMIM: 604046 MGI: 1917378 HomoloGene: 31288 GeneCards: OXSR1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,255,484 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	119,151,493 bp
RNA expression pattern
	Top expressed in
	body of tongue; ; saphenous vein; ; gastrocnemius muscle; ; embryo; ; ganglionic eminence; ; deltoid muscle; ; bone marrow; ; monocyte; ; secondary oocyte; ; biceps brachii;
	Top expressed in
	skeletal muscle tissue; ; quadriceps femoris muscle; ; cumulus cells; ; knee joint; ; triceps brachii muscle; ; ankle; ; medullary collecting duct; ; gastrocnemius muscle; ; thoracic diaphragm; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	magnesium ion binding ; protein kinase activity ; protein binding ; kinase activity ; metal ion binding ; nucleotide binding ; transferase activity ; ATP binding ; protein serine/threonine kinase activity ; identical protein binding ; protein kinase binding ;
Cellular component	extracellular exosome ; cytoplasm ; cytosol ;
Biological process	response to oxidative stress ; negative regulation of potassium ion transmembrane transport ; cellular hypotonic response ; phosphorylation ; negative regulation of potassium ion transmembrane transporter activity ; protein phosphorylation ; peptidyl-threonine phosphorylation ; intracellular signal transduction ; regulation of mitotic cell cycle ; signal transduction ; stress-activated protein kinase signaling cascade ; activation of protein kinase activity ; regulation of apoptotic process ; osmosensory signaling pathway ; positive regulation of T cell chemotaxis ; chemokine (C-C motif) ligand 21 signaling pathway ; chemokine (C-X-C motif) ligand 12 signaling pathway ; protein autophosphorylation ; cellular response to chemokine ;
	Sources:Amigo / QuickGO
Orthologs
	9943
	108737
	ENSG00000172939
	ENSMUSG00000036737
	O95747
	Q6P9R2
	NM_005109
	NM_133985 ; NM_001359582
	NP_005100
	NP_598746 ; NP_001346511
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 17, 2022

Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.^[5]^[6]

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.^[6]

Related Research Articles

The sodium-chloride symporter (also known as Na⁺-Cl⁻ cotransporter, NCC or NCCT, or as the thiazide-sensitive Na⁺-Cl⁻ cotransporter or TSC) is a cotransporter in the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron. It is a member of the SLC12 cotransporter family of electroneutral cation-coupled chloride cotransporters. In humans, it is encoded by the SLC12A3 gene (solute carrier family 12 member 3) located in 16q13.

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.

WNK , also known as WNK1, is an enzyme that is encoded by the WNK1 gene. WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family. The predominant role of WNK1 is the regulation of cation-Cl⁻ cotransporters (CCCs) such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl symporter (NKCC1), and potassium chloride cotransporter (KCC1) located within the kidney. CCCs mediate ion homeostasis and modulate blood pressure by transporting ions in and out of the cell. WNK1 mutations as a result have been implicated in blood pressure disorders/diseases; a prime example being familial hyperkalemic hypertension (FHHt).

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.

Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. It is of the Src family of tyrosine kinases.

Serine/threonine protein kinase WNK4 also known as WNK lysine deficient protein kinase 4 or WNK4, is an enzyme that in humans is encoded by the WNK4 gene. Missense mutations cause a genetic form of pseudohypoaldosteronism type 2, also called Gordon syndrome.

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.

Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.

Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.

Serine/threonine-protein kinase LMTK1 is an enzyme that in humans is encoded by the (AATK) gene.

Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172939 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036737 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tamari M, Daigo Y, Nakamura Y (Apr 1999). "Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3". J Hum Genet. 44 (2): 116–20. doi: 10.1007/s100380050121 . PMID 10083736.
1 2 "Entrez Gene: OXSR1 oxidative-stress responsive 1".

Daigo Y, Isomura M, Nishiwaki T, et al. (1999). "Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3". DNA Res. 6 (1): 37–44. doi: 10.1093/dnares/6.1.37 . PMID 10231028.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID 10470851.
Piechotta K, Lu J, Delpire E (2003). "Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)". J. Biol. Chem. 277 (52): 50812–9. doi: 10.1074/jbc.M208108200 . PMID 12386165.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Chen W, Yazicioglu M, Cobb MH (2004). "Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily". J. Biol. Chem. 279 (12): 11129–36. doi: 10.1074/jbc.M313562200 . PMID 14707132.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Moriguchi T, Urushiyama S, Hisamoto N, et al. (2006). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1". J. Biol. Chem. 280 (52): 42685–93. doi: 10.1074/jbc.M510042200 . PMID 16263722.
Cusick JK, Xu LG, Bin LH, et al. (2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1". Biochem. Biophys. Res. Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.
Vitari AC, Thastrup J, Rafiqi FH, et al. (2006). "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1". Biochem. J. 397 (1): 223–31. doi:10.1042/BJ20060220. PMC 1479760 . PMID 16669787.
Anselmo AN, Earnest S, Chen W, et al. (2006). "WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells". Proc. Natl. Acad. Sci. U.S.A. 103 (29): 10883–8. Bibcode:2006PNAS..10310883A. doi: 10.1073/pnas.0604607103 . PMC 1544143 . PMID 16832045.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Villa F, Goebel J, Rafiqi FH, et al. (2007). "Structural insights into the recognition of substrates and activators by the OSR1 kinase". EMBO Rep. 8 (9): 839–45. doi:10.1038/sj.embor.7401048. PMC 1973955 . PMID 17721439.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172939 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036737 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10083736-5] Tamari M, Daigo Y, Nakamura Y (Apr 1999). "Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3". J Hum Genet. 44 (2): 116–20. doi: 10.1007/s100380050121 . PMID 10083736.

[entrez-6] 1 2 "Entrez Gene: OXSR1 oxidative-stress responsive 1".

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OXSR1

Related Research Articles

References

Further reading