Placing ovarian tissue strips into the preserving solution
Oncofertility is a subfield that bridges oncology and reproductive research to support fertility preservation in cancer survivors. Cancer treatments, such as chemotherapy, radiation, and surgery, may reduce or destroy a person's ability to have children later in life. Oncofertility also encompasses reproductive issues after cancer treatment, such as family planning, complex contraception, hormonal management throughout survivorship, surrogacy, and adoption. As of 2024[update], oncofertility services are available in most countries outside of Africa.[1]
About 10% of people being treated for cancer are younger than age 40 at the time of diagnosis. As cancer death rates decrease, the preservation of fertility in younger people becomes important to their post-treatment life plans. Preserving fertility prior to cancer treatment can provide hope at the time of diagnosis for families.
Fertility options for men
Established fertility preservation options for men include sperm banking, in which a semen sample is produced, frozen, and stored for future use,[2] and testicular sperm extraction, during which sperm is retrieved directly from the testes through a short surgical procedure and frozen. Experimental options include testicular tissue banking, in which testicular tissue is surgically removed and frozen.[1]
Frozen sperm can be discarded if fertility resumes after treatment.[1] About 10% of adult men who attempt to bank sperm are already infertile.[1]
Men who do not preserve their fertility prior to cancer treatment may have children through donor sperm, using sperm from a known or anonymous donor to achieve a pregnancy with a female partner, or by using assisted reproductive technologies or adoption.[citation needed]
Fertility options for women
Cryopreserving ovarian tissue strips
Options for women to have children after cancer have increased significantly in recent years.[3] Women should be counseled on established options such as embryo banking in which hormonal stimulation causes the production of multiple eggs, which are removed, fertilized by sperm, and frozen for future use.
Egg banking is a process of extracting and freezing unfertilized eggs.[4] It uses hormonal stimulation to trigger the production of multiple eggs, which are surgically removed and frozen for storage and future use. The success rate for is lower than most women expect, requiring, on average, about 10 frozen eggs to be used for each live birth.[4]
For radiation, ovarian transposition (surgically moving the ovaries to a different part of the body) and ovarian shielding (physically shielding the ovaries from the area receiving radiation) may be used.[5]
Experimental techniques include ovarian tissue banking in which an ovary is surgically removed and frozen to be transplanted back into the woman when she is ready to have children. Scientists are also working on ways to mature undeveloped eggs from this ovarian tissue. [citation needed]
After sterilizing cancer treatment, permanent damage to the uterus could be sustained.[6] A woman can also choose surrogacy (when a woman carries a pregnancy for another woman or couple) or adoption.
Fertility preservation costs may be high for young patients, and multiple organizations now provide methods to reduce costs for patients.[8] For example, depending on how a country handles healthcare costs and health insurance, the cancer survivor may have to pay directly for the cost of storing frozen sperm.[1]
↑ Sheth, Kunj R.; Sharma, Vidit; Helfand, Brian T.; Cashy, John; Smith, Kristin; Hedges, Jason C.; Köhler, Tobias S.; Woodruff, Teresa K.; Brannigan, Robert E. (2012). "Improved Fertility Preservation Care for Male Patients with Cancer After Establishment of Formalized Oncofertility Program". The Journal of Urology. 187 (3): 979–86. doi:10.1016/j.juro.2011.10.154. PMID22264454.
↑ Noyes, Nicole; Knopman, Jaime M.; Long, Kara; Coletta, Jaclyn M.; Abu-Rustum, Nadeem R. (2011). "Fertility considerations in the management of gynecologic malignancies". Gynecologic Oncology. 120 (3): 326–33. doi:10.1016/j.ygyno.2010.09.012. PMID20943258.
1 2 Fuchs Weizman, N.; Baram, S.; Montbriand, J.; Librach, C. L. (May 2021). "Planned oocyte cryopreservation (Planned OC): systematic review and meta-analysis of cost-efficiency and patients' perspective". BJOG: An International Journal of Obstetrics and Gynaecology. 128 (6): 950–962. doi:10.1111/1471-0528.16555. ISSN1471-0528. PMID33021076.
↑ Jungheim, Emily S.; Carson, Kenneth R.; Brown, Douglas (2010). "Counseling and Consenting Women with Cancer on Their Oncofertility Options: A Clinical Perspective". Oncofertility. Cancer Treatment and Research. Vol.156. pp.403–12. doi:10.1007/978-1-4419-6518-9_31. ISBN978-1-4419-6517-2. PMC3071538. PMID20811851.
↑ Griffiths M, Marshall S, Cousins F, Alesi L, Higgins J, Giridharan S, Sarma U, Menkhorst E, Zhou W, Care A, Donoghue J, Holdsworth-Carson S, Rogers P, Dimitriadis E, Gargett C ,Robertson S, Winship A & Hutt K. Radiotherapy exposure directly damages the uterus and causes pregnancy loss. (2023) JCI Insight. 8(6):e163704. doi: 10.1172/jci.insight.163704 PMID 36946464
↑ Galvin, Kathleen M.; Clayman, Marla L. (2010). "Whose Future Is It? Ethical Family Decision Making About Daughters' Treatment in the Oncofertility Context". Oncofertility. Cancer Treatment and Research. Vol.156. pp.429–45. doi:10.1007/978-1-4419-6518-9_33. ISBN978-1-4419-6517-2. PMC3086488. PMID20811853.
This page is based on this Wikipedia article Text is available under the CC BY-SA 4.0 license; additional terms may apply. Images, videos and audio are available under their respective licenses.
