Menopause, also known as the climacteric, is the time when menstrual periods permanently stop, marking the end of reproduction. It typically occurs between the ages of 45 and 55, although the exact timing can vary. Menopause is usually a natural change. It can occur earlier in those who smoke tobacco. Other causes include surgery that removes both ovaries or some types of chemotherapy. At the physiological level, menopause happens because of a decrease in the ovaries' production of the hormones estrogen and progesterone. While typically not needed, a diagnosis of menopause can be confirmed by measuring hormone levels in the blood or urine. Menopause is the opposite of menarche, the time when a girl's periods start.
Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone. FSH is synthesized and secreted by the gonadotropic cells of the anterior pituitary gland and regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and luteinizing hormone (LH) work together in the reproductive system.
The hypothalamic–pituitary–gonadal axis refers to the hypothalamus, pituitary gland, and gonadal glands as if these individual endocrine glands were a single entity. Because these glands often act in concert, physiologists and endocrinologists find it convenient and descriptive to speak of them as a single system.
Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.
Reproductive medicine is a branch of medicine concerning the male and female reproductive systems. It encompasses a variety of reproductive conditions, their prevention and assessment, as well as their subsequent treatment and prognosis.
In vitro maturation (IVM) is the technique of letting the contents of ovarian follicles and the oocytes inside mature in vitro. It can be offered to women with infertility problems, combined with In Vitro Fertilization (IVF), offering women pregnancy without ovarian stimulation.
The Oncofertility Consortium is an international, multi-institutional group that assesses the impact of cancer and its treatment on reproductive health. Founded by Dr. Teresa Woodruff in 2007, its primary mission is to expand fertility options for cancer survivors. It has since expanded this mission to include non-oncologic conditions that affect fertility, including differences of sex development, gender-affirming treatment, and transfusion-dependent thalassemia.
Fertility preservation is the effort to help cancer patients retain their fertility, or ability to procreate. Research into how cancer, ageing and other health conditions effect reproductive health and preservation options are growing. Specifically sparked in part by the increase in the survival rate of cancer patients.
Inhibin, beta B, also known as INHBB, is a protein which in humans is encoded by the INHBB gene. INHBB is a subunit of both activin and inhibin, two closely related glycoproteins with opposing biological effects.
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely, inhibin downregulates FSH synthesis and inhibits FSH secretion. The existence of inhibin was hypothesized as early as 1916; however, it was not demonstrated to exist until Neena Schwartz and Cornelia Channing's work in the mid-1970s, after which both proteins were molecularly characterized ten years later.
Oncofertility is a subfield that bridges oncology and reproductive research to explore and expand options for the reproductive future of cancer survivors. The name was coined in 2006 by Teresa K. Woodruff at the Oncofertility Consortium.
Sandra Ann Carson is an American obstetrician who is the principal innovator of the first artificial human ovary. This innovation was reported in the Journal of Assisted Reproduction and Genetics, and recognized by Time magazine as one of the top 10 medical breakthroughs in 2010.
Follicle-stimulating hormone (FSH) insensitivity, or ovarian insensitivity to FSH in females, also referable to as ovarian follicle hypoplasia or granulosa cell hypoplasia in females, is a rare autosomal recessive genetic and endocrine syndrome affecting both females and males, with the former presenting with much greater severity of symptomatology. It is characterized by a resistance or complete insensitivity to the effects of follicle-stimulating hormone (FSH), a gonadotropin which is normally responsible for the stimulation of estrogen production by the ovaries in females and maintenance of fertility in both sexes. The condition manifests itself as hypergonadotropic hypogonadism, reduced or absent puberty, amenorrhea, and infertility in females, whereas males present merely with varying degrees of infertility and associated symptoms.
Hilary Octavia Dawn Critchley FRSE FRSB FMedSci FFSRH FRCOG FRANZCOG is a Scottish obstetrician and gynaecologist. as of 2014, she is the Professor of Reproductive Medicine and an Honorary Consultant in Obstetrics and Gynaecology at the University of Edinburgh.
Neena Betty Schwartz was an American endocrinologist and William Deering Professor of Endocrinology Emerita in the Department of Neurobiology at Northwestern University. She was best known for her work on female reproductive biology and the regulation of hormonal signaling pathways, particularly for the discovery of the signaling hormone inhibin. Schwartz was an active feminist advocate for women in science throughout her career; she was a founding member of the Association for Women in Science organization in 1971 and shared the founding presidency with Judith Pool. She also co-founded the Women in Endocrinology group under the auspices of the Endocrine Society, served terms as the president of the Endocrine Society and the Society for the Study of Reproduction, and was recognized for her exceptional mentorship of women scientists. In 2010, she published a memoir of her life in science, A Lab of My Own, in which she came out as lesbian.
Laurie Zoloth is an American ethicist, currently Margaret E. Burton Professor at the University of Chicago Divinity School. She was the first Jewish dean of the Divinity School and served in the position from 2017 to 2018, whereupon she was invited to serve as the first Senior Advisor on Programs on Social Ethics for the University, an advisory administrative position.
Evelyn Elizabeth Telfer is a reproductive biologist and professor at the University of Edinburgh. She leads a research team which has successfully grown immature human eggs to maturity in the lab, and discovered that human ovaries are capable of growing new eggs. In 2018 she was named one of Porter magazine's Incredible Women of 2018. In January 2019 she delivered the Anne McLaren Memorial Lecture at the Joint Fertility Societies Meeting in Birmingham: Fertility 2019. The Society of Reproduction and Fertility (SRF) presented her with their Distinguished Scientist award. Professor Telfer was presented with the Marshall Medal by SRF at Fertility 2023 in Belfast in recognition of her world leading contributions to the field of ovarian function and fertility preservation. The Marshall Medal is the Society’s premier award established in 1963 to commemorate the life and work of the eminent physiologist FHA Marshall.
Ovarian follicle dominance is the process where one or more follicles are selected per cycle to ovulate.
Janet Elizabeth Hall is a Canadian-American physician-scientist and neuroendocrinologist specialized in the human reproductive physiology and pathophysiology. Her research focuses on women's health and the neuroendocrine interactions governing normal reproduction and the impact of aging. She is the clinical director at the National Institute of Environmental Health Sciences. Hall was previously a professor of medicine at the Harvard Medical School.
Linda C. Giudice is an American gynecologist and obstetrician whose research has focused on the genetics of infertility, endometriosis, and the mechanisms of the menstrual cycle, along with the impacts of environmental pollutants on women's fertility. A New Yorker, she had an accelerated education with a heavy emphasis on the sciences, moving through multiple disciplines of engineering for her undergraduate and graduate degrees. Her postdoctoral fellowships introduced her to translational medicine and the genetics of women's health, resulting in her returning to her studies to obtain a medical degree.
