P53AIP1

TP53AIP1
Identifiers
Aliases	TP53AIP1 , P53AIP1, tumor protein p53 regulated apoptosis inducing protein 1
External IDs	OMIM: 605426; HomoloGene: 137360; GeneCards: TP53AIP1; OMA:TP53AIP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.3 Start 128,934,731 bp [1] End 128,943,399 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell hair follicle gingival epithelium skin of abdomen skin of limb skin of leg skin of arm testicle vagina vulva n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component mitochondrion mitochondrial matrix Biological process apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63970 n/a Ensembl ENSG00000120471 n/a UniProt Q9HCN2 n/a RefSeq (mRNA) NM_022112 NM_001195194 NM_001195195 NM_001251964 n/a RefSeq (protein) NP_001182123 NP_001182124 NP_001238893 NP_071395 n/a Location (UCSC) Chr 11: 128.93 – 128.94 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

p53-regulated apoptosis-inducing protein 1 is a protein that in humans is encoded by the TP53AIP1 gene. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000120471 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y (Oct 2000). "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53". Cell. 102 (6): 849–62. doi: 10.1016/S0092-8674(00)00073-8 . PMID   11030628. S2CID   3051667.
4. Matsuda K, Yoshida K, Taya Y, Nakamura K, Nakamura Y, Arakawa H (May 2002). "p53AIP1 regulates the mitochondrial apoptotic pathway". Cancer Res. 62 (10): 2883–9. PMID   12019168.
5. "Entrez Gene: P53AIP1 p53-regulated apoptosis-inducing protein 1".

Further reading

• Strano S, Monti O, Pediconi N, et al. (2005). "The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage". Mol. Cell. 18 (4): 447–59. doi: 10.1016/j.molcel.2005.04.008 . PMID   15893728.
• Wesierska-Gadek J, Gueorguieva M, Horky M (2005). "Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells". Mol. Cancer Ther. 4 (1): 113–24. doi: 10.1158/1535-7163.113.4.1 . PMID   15657359.
• Chan KT, Lung ML (2004). "Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line". Cancer Chemother. Pharmacol. 53 (6): 519–26. doi:10.1007/s00280-004-0767-4. PMID   15004724. S2CID   13125987.
• Kövesi G, Szende B (2004). "Changes in apoptosis and mitotic index, p53 and Ki67 expression in various types of oral leukoplakia". Oncology. 65 (4): 331–6. doi:10.1159/000074646. PMID   14707453. S2CID   19136670.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi: 10.1126/science.1058040 . PMID   11181995.