PANK4

PANK4
Identifiers
Aliases	PANK4 , pantothenate kinase 4, pantothenate kinase 4 (inactive), CTRCT49
External IDs	OMIM: 606162 MGI: 2387466 HomoloGene: 41235 GeneCards: PANK4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	2,526,597 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,065,395 bp
RNA expression pattern
	Top expressed in
	blood; ; gastrocnemius muscle; ; skeletal muscle tissue; ; left ventricle; ; pituitary gland; ; anterior pituitary; ; spleen; ; right lobe of thyroid gland; ; Right adrenal gland; ; left lobe of thyroid gland;
	Top expressed in
	interventricular septum; ; extraocular muscle; ; digastric muscle; ; vastus lateralis muscle; ; soleus muscle; ; temporal muscle; ; retinal pigment epithelium; ; facial motor nucleus; ; tibialis anterior muscle; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; pantothenate kinase activity ; ATP binding ; kinase activity ;
Cellular component	cytoplasm ;
Biological process	coenzyme A biosynthetic process ; phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	55229
	269614
	ENSG00000157881 ; ENSG00000273494
	ENSMUSG00000029056
	Q9NVE7
	Q80YV4
	NM_018216
	NM_172990 ; NM_001305804
	NP_060686
NP_001292733 ; NP_766578 ; NP_001392980 ; NP_001392981 ; NP_001392982 ;
	NP_001392983 ; NP_001392984 ; NP_001392985
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Pantothenate kinase 4 is an enzyme (pantothenate kinase) that in humans is encoded by the PANK4 gene.^[5]^[6]

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.^[6]

Related Research Articles

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References

1 2 3 ENSG00000273494 GRCh38: Ensembl release 89: ENSG00000157881, ENSG00000273494 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029056 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ (Jul 2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594. S2CID 20400095.
1 2 "Entrez Gene: PANK4 pantothenate kinase 4".

Robishaw JD, Neely JR (1985). "Coenzyme A metabolism". Am. J. Physiol. 248 (1 Pt 1): E1–9. doi:10.1152/ajpendo.1985.248.1.E1. PMID 2981478.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Li Y, Chang Y, Zhang L, et al. (2005). "High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2)". Mol. Cell. Biochem. 277 (1–2): 117–25. doi:10.1007/s11010-005-5535-1. PMID 16132722. S2CID 34385941.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000273494 GRCh38: Ensembl release 89: ENSG00000157881, ENSG00000273494 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029056 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11479594-5] Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ (Jul 2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID 11479594. S2CID 20400095.

[entrez-6] 1 2 "Entrez Gene: PANK4 pantothenate kinase 4".

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PANK4

Contents

See also

Related Research Articles

References

Further reading