PANK4

PANK4
Identifiers
Aliases	PANK4 , pantothenate kinase 4, pantothenate kinase 4 (inactive), CTRCT49
External IDs	OMIM: 606162; MGI: 2387466; HomoloGene: 41235; GeneCards: PANK4; OMA:PANK4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.32 Start 2,508,537 bp [1] End 2,526,597 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 E2 Start 155,048,580 bp [2] End 155,065,395 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right hemisphere of cerebellum blood granulocyte gastrocnemius muscle skeletal muscle tissue left ventricle right auricle of heart muscle of thigh pituitary gland Top expressed in neural layer of retina interventricular septum extraocular muscle otic vesicle digastric muscle vastus lateralis muscle soleus muscle temporal muscle retinal pigment epithelium muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding pantothenate kinase activity ATP binding kinase activity Cellular component cytoplasm Biological process coenzyme A biosynthetic process phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55229 269614 Ensembl ENSG00000157881 ENSG00000273494 ENSMUSG00000029056 UniProt Q9NVE7 Q80YV4 RefSeq (mRNA) NM_018216 NM_172990 NM_001305804 RefSeq (protein) NP_060686 NP_001292733 NP_766578 NP_001392980 NP_001392981 NP_001392982 NP_001392983 NP_001392984 NP_001392985 Location (UCSC) Chr 1: 2.51 – 2.53 Mb Chr 4: 155.05 – 155.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pantothenate kinase 4 is an enzyme (pantothenate kinase) that in humans is encoded by the PANK4 gene. ^{[5] [6]}

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. ^[6]

See also

• Pantothenate

References

1. ENSG00000273494 GRCh38: Ensembl release 89: ENSG00000157881, ENSG00000273494 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029056 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ (Jul 2001). "A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome". Nat Genet. 28 (4): 345–9. doi:10.1038/ng572. PMID   11479594. S2CID   20400095.
6. "Entrez Gene: PANK4 pantothenate kinase 4".

Further reading

• Robishaw JD, Neely JR (1985). "Coenzyme A metabolism". Am. J. Physiol. 248 (1 Pt 1): E1–9. doi:10.1152/ajpendo.1985.248.1.E1. PMID   2981478.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Li Y, Chang Y, Zhang L, et al. (2005). "High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2)". Mol. Cell. Biochem. 277 (1–2): 117–25. doi:10.1007/s11010-005-5535-1. PMID   16132722. S2CID   34385941.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.