PARP10

PARP10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DHX, 3HKV
Identifiers
Aliases	PARP10 , ARTD10, poly(ADP-ribose) polymerase family member 10
External IDs	OMIM: 609564 MGI: 3712326 HomoloGene: 53133 GeneCards: PARP10
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,012,772 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,127,641 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; right uterine tube; ; spleen; ; appendix; ; lymph node; ; right lobe of liver; ; right adrenal gland; ; monocyte; ; blood; ; parotid gland;
	Top expressed in
	thymus; ; duodenum; ; lip; ; spleen; ; proximal tubule; ; left lobe of liver; ; submandibular gland; ; ileum; ; blood; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; K63-linked polyubiquitin modification-dependent protein binding ; protein binding ; glycosyltransferase activity ; NAD+ ADP-ribosyltransferase activity ; protein ADP-ribosylase activity ;
Cellular component	cytoplasm ; nucleus ; nucleolus ; cytosol ; intracellular membrane-bounded organelle ;
Biological process	negative regulation of protein K63-linked ubiquitination ; protein auto-ADP-ribosylation ; negative regulation of NF-kappaB transcription factor activity ; protein ADP-ribosylation ; negative regulation of fibroblast proliferation ; negative regulation of gene expression ; NAD biosynthesis via nicotinamide riboside salvage pathway ; protein poly-ADP-ribosylation ; translesion synthesis ; protein mono-ADP-ribosylation ; DNA repair ; cellular response to DNA damage stimulus ;
	Sources:Amigo / QuickGO
Orthologs
	84875
	671535
	ENSG00000178685
	ENSMUSG00000063268
	Q53GL7
	Q8CIE4
	NM_032789 ; NM_001317895
	NM_001163575 ; NM_001163576
	NP_001304824 ; NP_116178
	NP_001157047 ; NP_001157048
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 17, 2024

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.^[5]^[6]

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM]^[6]

Related Research Articles

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.

Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD⁺ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. It is the most abundant of the PARP family of enzymes, accounting for 90% of the NAD+ used by the family. PARP1 is mostly present in cell nucleus, but cytosolic fraction of this protein was also reported.

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.

60S ribosomal protein L13a is a protein that in humans is encoded by the RPL13A gene.

Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.

Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene.

Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene. It is one of the PARP family of enzymes.

Diphthine synthase is an enzyme that in humans is encoded by the DPH5 gene.

(ADP-ribosyl)hydrolase 3 (ARH3) is an enzyme that in humans is encoded by the ADPRHL2 gene (also called ADPRS). This enzyme reverses the proteins’ post-translational addition of ADP-ribose to serine residues as part of the DNA damage response The enzyme is also known to cleave poly(ADP-ribose) polymers, 1''-O-acetyl-ADP-ribose and alpha-NAD⁺

Probable cation-transporting ATPase 13A3 is an enzyme that in humans is encoded by the ATP13A3 gene.

Poly [ADP-ribose] polymerase 8 is an enzyme that in humans is encoded by the PARP8 gene.

TCDD-inducible poly [ADP-ribose] polymerase is an enzyme that in humans is encoded by the TIPARP gene.

Zinc finger protein 219 is a protein that in humans is encoded by the ZNF219 gene.

DNA-directed RNA polymerase, mitochondrial is an enzyme that in humans is encoded by the POLRMT gene.

FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene.

DNA-directed RNA polymerase III subunit RPC5 is an enzyme that in humans is encoded by the POLR3E gene.

Tudor and KH domain-containing protein is a protein that in humans is encoded by the TDRKH gene.

Elongator complex protein 2 is a protein that in humans is encoded by the ELP2 gene.

Poly [ADP-ribose] polymerase 12 is an enzyme that in humans is encoded by the PARP12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178685 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063268 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi: 10.1002/bies.20085 . PMID 15273990. S2CID 25024719.
1 2 "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

Chou HY, Chou HT, Lee SC (2006). "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10)". J. Biol. Chem. 281 (22): 15201–7. doi: 10.1074/jbc.M506745200 . PMID 16455663.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Yu M, Schreek S, Cerni C, et al. (2005). "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation". Oncogene. 24 (12): 1982–93. doi:10.1038/sj.onc.1208410. PMID 15674325. S2CID 13330538.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178685 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063268 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15273990-5] Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi: 10.1002/bies.20085 . PMID 15273990. S2CID 25024719.

[entrez-6] 1 2 "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

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PARP10

Related Research Articles

References

Further reading