PASD1

PASD1
Identifiers
Aliases	PASD1 , CT63, OXTES1, PAS domain containing 1, PAS domain containing repressor 1, CT64
External IDs	OMIM: 300993; HomoloGene: 131196; GeneCards: PASD1; OMA:PASD1 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 151,563,675 bp [1] End 151,676,739 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis gonad human musculoskeletal system muscular system muscle skeletal muscle lower limb muscles muscle of leg n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator binding Cellular component Cry-Per complex nucleus nuclear speck Biological process negative regulation of circadian rhythm negative regulation of transcription, DNA-templated rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 139135 n/a Ensembl ENSG00000166049 n/a UniProt Q8IV76 n/a RefSeq (mRNA) NM_173493 n/a RefSeq (protein) NP_775764 n/a Location (UCSC) Chr X: 151.56 – 151.68 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene. ^{[3] [4] [5]}

PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function. ^{[6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000166049 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (July 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens". International Journal of Cancer. 110 (4): 563–569. doi: 10.1002/ijc.20170 . PMID   15122589.
4. Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (July 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein". British Journal of Cancer. 91 (1): 141–149. doi:10.1038/sj.bjc.6601875. PMC   2364759 . PMID   15162151.
5. "Entrez Gene: PASD1 PAS domain containing 1".
6. Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock". Molecular Cell. 58 (5): 743–754. doi:10.1016/j.molcel.2015.03.031. PMC   4458219 . PMID   25936801.
7. Greenwood V (15 September 2015). "How the Body's Trillions of Clocks Keep Time". Quanta Magazine .

Further reading

• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, et al. (October 2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochemical and Biophysical Research Communications. 335 (4): 1293–1304. doi:10.1016/j.bbrc.2005.08.024. PMID   16112646.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.