PASD1

PASD1
Identifiers
Aliases	PASD1 , CT63, OXTES1, PAS domain containing 1, PAS domain containing repressor 1, CT64
External IDs	OMIM: 300993 HomoloGene: 131196 GeneCards: PASD1
Gene location (Human)
Chr.	X chromosome (human)
End	151,676,739 bp
RNA expression pattern
	Top expressed in
	human musculoskeletal system; ; muscular system; ; muscle; ; muscle of leg; ; lower leg; ; gastrocnemius muscle; ; tibial nerve;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator binding ;
Cellular component	Cry-Per complex ; nucleus ; nuclear speck ;
Biological process	negative regulation of circadian rhythm ; negative regulation of transcription, DNA-templated ; rhythmic process ;
	Sources:Amigo / QuickGO
Orthologs
	139135
	n/a
	ENSG00000166049
	n/a
	Q8IV76
	n/a
	NM_173493
	n/a
	NP_775764
	n/a
	Wikidata
View/Edit Human

Last updated December 20, 2023

PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene.^[3]^[4]^[5]

PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function.^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166049 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (May 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens". Int J Cancer. 110 (4): 563–9. doi: 10.1002/ijc.20170 . PMID 15122589.
↑ Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (Jun 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein". Br J Cancer. 91 (1): 141–9. doi:10.1038/sj.bjc.6601875. PMC 2364759 . PMID 15162151.
↑ "Entrez Gene: PASD1 PAS domain containing 1".
↑ Michael, Alicia K.; Harvey, Stacy L.; Sammons, Patrick J.; Anderson, Amanda P.; Kopalle, Hema M.; Banham, Alison H.; Partch, Carrie L. (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock". Molecular Cell. 58 (5): 743–754. doi:10.1016/j.molcel.2015.03.031. PMC 4458219 . PMID 25936801.
↑ Greenwood, Veronique (15 September 2015). "How the Body's Trillions of Clocks Keep Time". Quanta Magazine .

PASD1

Related Research Articles

References

Further reading