PBK (gene)

PBK
Identifiers
Aliases	PBK , CT84, HEL164, Nori-3, SPK, TOPK, PDZ binding kinase
External IDs	OMIM: 611210 MGI: 1289156 HomoloGene: 32415 GeneCards: PBK
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.1 Start 27,809,624 bp [1] End 27,838,082 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 D1|14 34.36 cM Start 66,043,286 bp [2] End 66,055,271 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm ganglionic eminence secondary oocyte rectum stromal cell of endometrium appendix cavity of mouth thymus duodenum bone marrow Top expressed in spermatocyte medial ganglionic eminence superior cervical ganglion seminiferous tubule endocardial cushion Paneth cell renal corpuscle atrioventricular valve vas deferens somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein serine/threonine kinase activity protein kinase activity protein binding ATP binding Cellular component nucleus Biological process cellular response to UV negative regulation of protein phosphorylation protein phosphorylation negative regulation of stress-activated MAPK cascade negative regulation of inflammatory response phosphorylation negative regulation of proteasomal ubiquitin-dependent protein catabolic process mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55872 52033 Ensembl 55872 ENSMUSG00000022033 UniProt Q96KB5 Q9JJ78 RefSeq (mRNA) NM_001278945 NM_018492 NM_001363040 NM_023209 RefSeq (protein) NP_001265874 NP_060962 NP_001349969 NP_075698 Location (UCSC) Chr 8: 27.81 – 27.84 Mb Chr 14: 66.04 – 66.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene. ^{[5] [6] [7]}

The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. ^[7]

References

1. GRCh38: Ensembl release 89: 55872 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022033 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Abe Y, Matsumoto S, Kito K, Ueda N (Aug 2000). "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells". J Biol Chem. 275 (28): 21525–31. doi: 10.1074/jbc.M909629199 . PMID   10781613.
6. Gaudet S, Branton D, Lue RA (Jun 2000). "Characterization of PDZ-binding kinase, a mitotic kinase". Proc Natl Acad Sci U S A. 97 (10): 5167–72. Bibcode:2000PNAS...97.5167G. doi: 10.1073/pnas.090102397 . PMC   25800 . PMID   10779557.
7. "Entrez Gene: PBK PDZ binding kinase".

Further reading

• Zhao S, Dai J, Zhao W, et al. (2001). "PDZ-binding kinase participates in spermatogenesis". Int. J. Biochem. Cell Biol. 33 (6): 631–6. doi:10.1016/S1357-2725(01)00005-X. PMID   11378444.
• Simons-Evelyn M, Bailey-Dell K, Toretsky JA, et al. (2003). "PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells". Blood Cells Mol. Dis. 27 (5): 825–9. doi:10.1006/bcmd.2001.0452. PMID   11783945.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID   12620389.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Nandi A, Tidwell M, Karp J, Rapoport AP (2004). "Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells". Blood Cells Mol. Dis. 32 (1): 240–5. doi:10.1016/j.bcmd.2003.10.004. PMID   14757441.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Matsumoto S, Abe Y, Fujibuchi T, et al. (2005). "Characterization of a MAPKK-like protein kinase TOPK". Biochem. Biophys. Res. Commun. 325 (3): 997–1004. doi:10.1016/j.bbrc.2004.10.133. PMID   15541388.
• Sabio G, Arthur JS, Kuma Y, et al. (2005). "p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP". EMBO J. 24 (6): 1134–45. doi:10.1038/sj.emboj.7600578. PMC   556394 . PMID   15729360.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods. 2 (1): 47–53. doi:10.1038/nmeth726. PMID   15782160. S2CID   6135437.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Dougherty JD, Garcia AD, Nakano I, et al. (2006). "PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase". J. Neurosci. 25 (46): 10773–85. doi:10.1523/JNEUROSCI.3207-05.2005. PMC   6725850 . PMID   16291951.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Nandi AK, Ford T, Fleksher D, et al. (2007). "Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53". Biochem. Biophys. Res. Commun. 358 (1): 181–8. doi:10.1016/j.bbrc.2007.04.125. PMID   17482142.
• Oh SM, Zhu F, Cho YY, et al. (2007). "T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation". Cancer Res. 67 (11): 5186–94. doi: 10.1158/0008-5472.CAN-06-4506 . PMID   17545598.
• Zhu F, Zykova TA, Kang BS, et al. (2007). "Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells". Gastroenterology. 133 (1): 219–31. doi: 10.1053/j.gastro.2007.04.048 . PMID   17631144.

External links

• Overview of all the structural information available in the PDB for UniProt : Q96KB5 (Lymphokine-activated killer T-cell-originated protein kinase) at the PDBe-KB .