PCBD2

PCBD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C45
Identifiers
Aliases	PCBD2 , DCOH2, DCOHM, PHS2, pterin-4 alpha-carbinolamine dehydratase 2
External IDs	OMIM: 609836 MGI: 1919812 HomoloGene: 49987 GeneCards: PCBD2
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.1 Start 134,905,120 bp [1] End 135,007,959 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 B1 Start 55,727,368 bp [2] End 55,776,830 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • 4-alpha-hydroxytetrahydrobiopterin dehydratase activity • phenylalanine 4-monooxygenase activity • lyase activity Cellular component • nucleus • cellular component Biological process • tetrahydrobiopterin biosynthetic process • positive regulation of transcription, DNA-templated • protein homotetramerization • protein heterooligomerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84105	72562
Ensembl	ENSG00000132570	ENSMUSG00000021496
UniProt	Q9H0N5	Q9CZL5
RefSeq (mRNA)	NM_032151	NM_028281
RefSeq (protein)	NP_115527	NP_082557
Location (UCSC)	Chr 5: 134.91 – 135.01 Mb	Chr 13: 55.73 – 55.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Pterin-4-alpha-carbinolamine dehydratase 2 is an enzyme that in humans is encoded by the PCBD2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000132570 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021496 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rose RB, Pullen KE, Bayle JH, Crabtree GR, Alber T (Jun 2004). "Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2". Biochemistry. 43 (23): 7345–55. doi:10.1021/bi049620t. PMID   15182178.
6. Lim S, Jin K, Friedman E (Jul 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J Biol Chem. 277 (28): 25040–6. doi: 10.1074/jbc.M203257200 . PMID   11980910.
7. "Entrez Gene: PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Arias JM, Murbartián J, Perez-Reyes E (2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID   12646162.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Schaaf CP, Benzing J, Schmitt T, et al. (2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB J. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID   15546961. S2CID   17142907.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.