PCBD2

PCBD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C45
Identifiers
Aliases	PCBD2 , DCOH2, DCOHM, PHS2, pterin-4 alpha-carbinolamine dehydratase 2
External IDs	OMIM: 609836; MGI: 1919812; HomoloGene: 49987; GeneCards: PCBD2; OMA:PCBD2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.1 Start 134,905,120 bp [1] End 135,007,959 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 B1 Start 55,875,181 bp [2] End 55,924,643 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle deltoid muscle vastus lateralis muscle gastrocnemius muscle muscle of thigh biceps brachii Skeletal muscle tissue of biceps brachii endothelial cell Skeletal muscle tissue of rectus abdominis left ventricle Top expressed in renal corpuscle medullary collecting duct primary oocyte Epithelium of choroid plexus facial motor nucleus vestibular membrane of cochlear duct proximal tubule right kidney yolk sac Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding 4-alpha-hydroxytetrahydrobiopterin dehydratase activity phenylalanine 4-monooxygenase activity lyase activity Cellular component nucleus cellular component Biological process tetrahydrobiopterin biosynthetic process positive regulation of transcription, DNA-templated protein homotetramerization protein heterooligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84105 72562 Ensembl ENSG00000132570 ENSMUSG00000021496 UniProt Q9H0N5 Q9CZL5 RefSeq (mRNA) NM_032151 NM_028281 RefSeq (protein) NP_115527 NP_082557 Location (UCSC) Chr 5: 134.91 – 135.01 Mb Chr 13: 55.88 – 55.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pterin-4-alpha-carbinolamine dehydratase 2 is an enzyme that in humans is encoded by the PCBD2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000132570 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021496 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rose RB, Pullen KE, Bayle JH, Crabtree GR, Alber T (Jun 2004). "Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2". Biochemistry. 43 (23): 7345–55. doi:10.1021/bi049620t. PMID   15182178.
6. Lim S, Jin K, Friedman E (Jul 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J Biol Chem. 277 (28): 25040–6. doi: 10.1074/jbc.M203257200 . PMID   11980910.
7. "Entrez Gene: PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Arias JM, Murbartián J, Perez-Reyes E (2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID   12646162.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Schaaf CP, Benzing J, Schmitt T, et al. (2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB J. 19 (2): 267–9. doi: 10.1096/fj.04-1558fje . PMID   15546961. S2CID   17142907.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.