PCYOX1

PCYOX1
Identifiers
Aliases	PCYOX1 , PCL1, prenylcysteine oxidase 1
External IDs	OMIM: 610995; MGI: 1914131; HomoloGene: 9458; GeneCards: PCYOX1; OMA:PCYOX1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.3 Start 70,257,386 bp [1] End 70,281,185 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 D1 Start 86,362,988 bp [2] End 86,374,136 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland endothelial cell parietal pleura skin of hip gingival epithelium skin of thigh Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis Brodmann area 23 visceral pleura Top expressed in urothelium medullary collecting duct transitional epithelium of urinary bladder facial motor nucleus cumulus cell ureter vestibular sensory epithelium substantia nigra Epithelium of choroid plexus skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor prenylcysteine oxidase activity Cellular component plasma membrane extracellular exosome vacuolar membrane very-low-density lipoprotein particle lysosome Biological process prenylcysteine metabolic process chloride transport chloride transmembrane transport prenylcysteine catabolic process prenylated protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51449 66881 Ensembl ENSG00000116005 ENSMUSG00000029998 UniProt Q9UHG3 Q9CQF9 RefSeq (mRNA) NM_016297 NM_025823 NM_001355687 RefSeq (protein) NP_057381 NP_080099 NP_001342616 Location (UCSC) Chr 2: 70.26 – 70.28 Mb Chr 6: 86.36 – 86.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prenylcysteine oxidase 1 is an enzyme that in humans is encoded by the PCYOX1 gene. ^{[5] [6] [7]}

See also

• Prenylcysteine oxidase

References

1. GRCh38: Ensembl release 89: ENSG00000116005 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029998 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tschantz WR, Zhang L, Casey PJ (Jan 2000). "Cloning, expression, and cellular localization of a human prenylcysteine lyase". J Biol Chem. 274 (50): 35802–8. doi: 10.1074/jbc.274.50.35802 . PMID   10585463.
6. Digits JA, Pyun HJ, Coates RM, Casey PJ (Oct 2002). "Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase". J Biol Chem. 277 (43): 41086–93. doi: 10.1074/jbc.M208069200 . PMID   12186880.
7. "Entrez Gene: PCYOX1 prenylcysteine oxidase 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Zhang L, Tschantz WR, Casey PJ (1997). "Isolation and characterization of a prenylcysteine lyase from bovine brain". J. Biol. Chem. 272 (37): 23354–9. doi: 10.1074/jbc.272.37.23354 . PMID   9287348.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Wouters MM, Neefs JM, Kerchove d'Exaerde A, et al. (2006). "Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse jejunum" . Biochem. Biophys. Res. Commun. 346 (2): 491–500. doi:10.1016/j.bbrc.2006.05.132. PMID   16765319. S2CID   21347125.