PCYOX1

PCYOX1
Identifiers
Aliases	PCYOX1 , PCL1, prenylcysteine oxidase 1
External IDs	OMIM: 610995 MGI: 1914131 HomoloGene: 9458 GeneCards: PCYOX1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	70,281,185 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	86,374,136 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; endothelial cell; ; parietal pleura; ; Brodmann area 23; ; visceral pleura; ; seminal vesicula; ; vulva; ; lactiferous duct; ; renal medulla; ; synovial joint;
	Top expressed in
	urothelium; ; medullary collecting duct; ; facial motor nucleus; ; cumulus cell; ; ureter; ; substantia nigra; ; ciliary body; ; iris; ; seminal vesicula; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity ; oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor ; prenylcysteine oxidase activity ;
Cellular component	plasma membrane ; extracellular exosome ; vacuolar membrane ; very-low-density lipoprotein particle ; lysosome ;
Biological process	prenylcysteine metabolic process ; chloride transport ; chloride transmembrane transport ; prenylcysteine catabolic process ; prenylated protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	51449
	66881
	ENSG00000116005
	ENSMUSG00000029998
	Q9UHG3
	Q9CQF9
	NM_016297
	NM_025823 ; NM_001355687
	NP_057381
	NP_080099 ; NP_001342616
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Prenylcysteine oxidase 1 is an enzyme that in humans is encoded by the PCYOX1 gene.^[5]^[6]^[7]

Related Research Articles

Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene.

Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene.

Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.

High affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene.

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.

CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.

Mitochondrial import receptor subunit TOM22 homolog is a protein that in humans is encoded by the TOMM22 gene.

Phosphoglucomutase-2 is an enzyme that in humans is encoded by the PGM2 gene. PGM2 is a major isozyme in red blood cells.

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.

Chromatin modification-related protein MEAF6 is a protein that in humans is encoded by the MEAF6 gene.

AP-3 complex subunit sigma-2 is a protein that in humans is encoded by the AP3S2 gene.

Mitochondrial transcription termination factor 1, also known as MTERF1, is a protein which in humans is encoded by the MTERF gene.

TOM1-like protein 1 is a protein that in humans is encoded by the TOM1L1 gene.

Transcription factor ETV7 is a protein that in humans is encoded by the ETV7 gene.

ATPase WRNIP1 is an enzyme that in humans is encoded by the WRNIP1 gene. The protein is a member of AAA ATPase family.

28S ribosomal protein S28, mitochondrial is a protein that in humans is encoded by the MRPS28 gene.

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase is an enzyme that in humans is encoded by the PAOX gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116005 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029998 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tschantz WR, Zhang L, Casey PJ (Jan 2000). "Cloning, expression, and cellular localization of a human prenylcysteine lyase". J Biol Chem. 274 (50): 35802–8. doi: 10.1074/jbc.274.50.35802 . PMID 10585463.
↑ Digits JA, Pyun HJ, Coates RM, Casey PJ (Oct 2002). "Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase". J Biol Chem. 277 (43): 41086–93. doi: 10.1074/jbc.M208069200 . PMID 12186880.
↑ "Entrez Gene: PCYOX1 prenylcysteine oxidase 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Zhang L, Tschantz WR, Casey PJ (1997). "Isolation and characterization of a prenylcysteine lyase from bovine brain". J. Biol. Chem. 272 (37): 23354–9. doi: 10.1074/jbc.272.37.23354 . PMID 9287348.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943 . PMID 16335952.
Wouters MM, Neefs JM, Kerchove d'Exaerde A, et al. (2006). "Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse jejunum". Biochem. Biophys. Res. Commun. 346 (2): 491–500. doi:10.1016/j.bbrc.2006.05.132. PMID 16765319. S2CID 21347125.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116005 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029998 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585463-5] Tschantz WR, Zhang L, Casey PJ (Jan 2000). "Cloning, expression, and cellular localization of a human prenylcysteine lyase". J Biol Chem. 274 (50): 35802–8. doi: 10.1074/jbc.274.50.35802 . PMID 10585463.

[pmid12186880-6] Digits JA, Pyun HJ, Coates RM, Casey PJ (Oct 2002). "Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase". J Biol Chem. 277 (43): 41086–93. doi: 10.1074/jbc.M208069200 . PMID 12186880.

[entrez-7] "Entrez Gene: PCYOX1 prenylcysteine oxidase 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

PCYOX1

Contents

See also

Related Research Articles

References

Further reading