PCYT1A

PCYT1A
Identifiers
Aliases	PCYT1A , CCTA, CT, CTA, CTPCT, PCYT1, SMDCRD, phosphate cytidylyltransferase 1, choline, alpha, phosphate cytidylyltransferase 1A, choline, CCTalpha
External IDs	OMIM: 123695 MGI: 88557 HomoloGene: 3680 GeneCards: PCYT1A
Gene location (Human)
Chr.	Chromosome 3 (human)
End	196,287,957 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	32,293,888 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; monocyte; ; skin of abdomen; ; duodenum; ; blood; ; tibia; ; nipple; ; stromal cell of endometrium; ; muscle of leg; ; internal globus pallidus;
	Top expressed in
	triceps brachii muscle; ; temporal muscle; ; Epithelium of stomach; ; extensor digitorum longus muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; plantaris muscle; ; jejunum; ; duodenum; ; knee joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotidyltransferase activity ; catalytic activity ; protein homodimerization activity ; lipid binding ; choline-phosphate cytidylyltransferase activity ; calmodulin binding ; phosphatidylcholine binding ;
Cellular component	cytoplasm ; cytosol ; membrane ; endoplasmic reticulum membrane ; glycogen granule ; nuclear envelope ; endoplasmic reticulum ; plasma membrane ;
Biological process	biosynthetic process ; lipid metabolism ; phospholipid biosynthetic process ; phosphatidylcholine biosynthetic process ; CDP-choline pathway ;
	Sources:Amigo / QuickGO
Orthologs
	5130
	13026
	ENSG00000161217
	ENSMUSG00000005615
	P49585
	P49586
	NM_005017 ; NM_001312673
	NM_001163159 ; NM_001163160 ; NM_009981
	NP_001299602 ; NP_005008
	NP_001156631 ; NP_001156632 ; NP_034111
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Choline-phosphate cytidylyltransferase A is an enzyme that in humans is encoded by the PCYT1A gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000161217 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005615 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kalmar GB, Kay RJ, LaChance AC, Cornell RB (Nov 1994). "Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase". Biochim Biophys Acta. 1219 (2): 328–34. doi:10.1016/0167-4781(94)90056-6. PMID 7918629.
↑ "Entrez Gene: PCYT1A phosphate cytidylyltransferase 1, choline, alpha".

Hunt AN, Normand CS, Postle AD (1990). "CTP:cholinephosphate cytidylyltransferase in human and rat lung: association in vitro with cytoskeletal actin". Biochim. Biophys. Acta. 1043 (1): 19–26. doi:10.1016/0005-2760(90)90105-7. PMID 2155660.
Vance JE, Vance DE (1988). "Does rat liver Golgi have the capacity to synthesize phospholipids for lipoprotein secretion?". J. Biol. Chem. 263 (12): 5898–909. doi: 10.1016/S0021-9258(18)60650-7 . PMID 2833521.
Weinhold PA, Feldman DA (1995). "Fatty acids promote the formation of complexes between choline-phosphate cytidylyltransferase and cytidylyltransferase binding protein". Arch. Biochem. Biophys. 318 (1): 147–56. doi:10.1006/abbi.1995.1215. PMID 7726555.
Johnson JE, Cornell RB (1994). "Membrane-binding amphipathic alpha-helical peptide derived from CTP:phosphocholine cytidylyltransferase". Biochemistry. 33 (14): 4327–35. doi:10.1021/bi00180a029. PMID 8155650.
Dunne SJ, Cornell RB, Johnson JE, et al. (1996). "Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferase". Biochemistry. 35 (37): 11975–84. doi:10.1021/bi960821+. PMID 8810902.
Arnold RS, DePaoli-Roach AA, Cornell RB (1997). "Binding of CTP:phosphocholine cytidylyltransferase to lipid vesicles: diacylglycerol and enzyme dephosphorylation increase the affinity for negatively charged membranes". Biochemistry. 36 (20): 6149–56. doi:10.1021/bi970023z. PMID 9166786.
Yang J, Wang J, Tseu I, et al. (1997). "Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions". Biochem. J. 325. ( Pt 1): 29–38. doi:10.1042/bj3250029. PMC 1218525 . PMID 9224626.
Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant". J. Biol. Chem. 274 (38): 26992–7001. doi: 10.1074/jbc.274.38.26992 . PMID 10480912.
Lagace TA, Miller JR, Ridgway ND (2002). "Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis". Mol. Cell. Biol. 22 (13): 4851–62. doi:10.1128/MCB.22.13.4851-4862.2002. PMC 133913 . PMID 12052891.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Guenther MG, Yu J, Kao GD, et al. (2003). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes Dev. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500 . PMID 12502735.
Xie M, Smith JL, Ding Z, et al. (2004). "Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase". J. Biol. Chem. 279 (27): 28817–25. doi: 10.1074/jbc.M403311200 . PMID 15069071.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Enaw JO, Zhu H, Yang W, et al. (2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population". BMC Medicine. 4: 36. doi:10.1186/1741-7015-4-36. PMC 1770928 . PMID 17184542.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000161217 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005615 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7918629-5] Kalmar GB, Kay RJ, LaChance AC, Cornell RB (Nov 1994). "Primary structure and expression of a human CTP:phosphocholine cytidylyltransferase". Biochim Biophys Acta. 1219 (2): 328–34. doi:10.1016/0167-4781(94)90056-6. PMID 7918629.

[entrez-6] "Entrez Gene: PCYT1A phosphate cytidylyltransferase 1, choline, alpha".

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PCYT1A

Related Research Articles

References

Further reading