PDE11A

PDE11A
Identifiers
Aliases	PDE11A , PPNAD2, phosphodiesterase 11A
External IDs	OMIM: 604961; MGI: 3036251; HomoloGene: 56763; GeneCards: PDE11A; OMA:PDE11A - orthologs
Gene location (Mouse) Chr. Chromosome 2 (mouse) [1] Band 2|2 C3 Start 75,819,485 bp [1] End 76,169,118 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in deltoid muscle quadriceps femoris muscle vastus lateralis muscle liver gastrocnemius muscle prostate biceps brachii right lobe of liver tibialis anterior muscle tibia Top expressed in hippocampus proper dentate gyrus of hippocampal formation granule cell embryo ileum primary visual cortex midbrain tegmentum jejunum Cortex of frontal lobe white adipose tissue cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity catalytic activity 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity metal ion binding cGMP-stimulated cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity cyclic-nucleotide phosphodiesterase activity cGMP binding Cellular component cytoplasm cytosol cellular component Biological process metabolism signal transduction G protein-coupled receptor signaling pathway negative regulation of cGMP-mediated signaling negative regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50940 241489 Ensembl n/a ENSMUSG00000075270 UniProt Q9HCR9 P0C1Q2 RefSeq (mRNA) NM_016953 NM_001077196 NM_001077197 NM_001077358 NM_001081033 RefSeq (protein) NP_001070664 NP_001070665 NP_001070826 NP_058649 NP_001074502 Location (UCSC) n/a Chr 2: 75.82 – 76.17 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. ^{[4] [5]}

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing's disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. ^[5]

Inhibitors

• BC11-38 ^[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000075270 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi: 10.1073/pnas.050585197 . PMC   16303 . PMID   10725373.
5. "Entrez Gene: PDE11A phosphodiesterase 11A".
6. Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi: 10.1016/j.chembiol.2011.12.010 . hdl: 2345/2934 . PMID   22284362.

Further reading

• Beavo JA, Conti M, Heaslip RJ (1994). "Multiple cyclic nucleotide phosphodiesterases". Mol. Pharmacol. 46 (3): 399–405. PMID   7935318.
• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Yuasa K, Kotera J, Fujishige K, et al. (2000). "Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression". J. Biol. Chem. 275 (40): 31469–79. doi: 10.1074/jbc.M003041200 . PMID   10906126.
• Hetman JM, Robas N, Baxendale R, et al. (2001). "Cloning and characterization of two splice variants of human phosphodiesterase 11A". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12891–5. doi: 10.1073/pnas.200355397 . PMC   18860 . PMID   11050148.
• Yuasa K, Kanoh Y, Okumura K, Omori K (2001). "Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains". Eur. J. Biochem. 268 (1): 168–78. doi:10.1046/j.1432-1327.2001.01866.x. PMID   11121118.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID   11156964. S2CID   26315564.
• Yuasa K, Ohgaru T, Asahina M, Omori K (2001). "Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants". Eur. J. Biochem. 268 (16): 4440–8. doi: 10.1046/j.1432-1327.2001.02366.x . PMID   11502204.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Weeks JL, Zoraghi R, Beasley A, et al. (2005). "High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients". Int. J. Impot. Res. 17 (1): 5–9. doi:10.1038/sj.ijir.3901283. PMID   15538396. S2CID   20459148.
• Loughney K, Taylor J, Florio VA (2005). "3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues". Int. J. Impot. Res. 17 (4): 320–5. doi:10.1038/sj.ijir.3901317. PMID   15800651. S2CID   23220517.
• Wayman C, Phillips S, Lunny C, et al. (2005). "Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology". Int. J. Impot. Res. 17 (3): 216–23. doi:10.1038/sj.ijir.3901307. PMID   15800654. S2CID   19852638.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• D'Andrea MR, Qiu Y, Haynes-Johnson D, et al. (2005). "Expression of PDE11A in normal and malignant human tissues". J. Histochem. Cytochem. 53 (7): 895–903. doi: 10.1369/jhc.5A6625.2005 . PMID   15995148.
• Francis SH (2005). "Phosphodiesterase 11 (PDE11): is it a player in human testicular function?". Int. J. Impot. Res. 17 (5): 467–8. doi: 10.1038/sj.ijir.3901377 . PMID   16079899.
• Gross-Langenhoff M, Hofbauer K, Weber J, et al. (2006). "cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11". J. Biol. Chem. 281 (5): 2841–6. doi: 10.1074/jbc.M511468200 . PMID   16330539.
• Horvath A, Boikos S, Giatzakis C, et al. (2006). "A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia". Nat. Genet. 38 (7): 794–800. doi:10.1038/ng1809. PMID   16767104. S2CID   30482549.
• Wong ML, Whelan F, Deloukas P, et al. (2006). "Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response". Proc. Natl. Acad. Sci. U.S.A. 103 (41): 15124–9. Bibcode:2006PNAS..10315124W. doi: 10.1073/pnas.0602795103 . PMC   1581426 . PMID   17008408.