PDE1A

PDE1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LXQ
Identifiers
Aliases	PDE1A , CAM-PDE-1A, HCAM-1, HCAM1, HSphosphodiesterase 1A, CAM-PDE 1A
External IDs	OMIM: 171890 MGI: 1201792 HomoloGene: 21043 GeneCards: PDE1A
Gene location (Human)
Chr.	Chromosome 2 (human)
End	182,523,359 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	79,959,802 bp
RNA expression pattern
	Top expressed in
	sperm; ; Brodmann area 23; ; middle temporal gyrus; ; renal medulla; ; entorhinal cortex; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; cerebellar cortex; ; cerebellar hemisphere;
	Top expressed in
	spermatid; ; seminiferous tubule; ; superior frontal gyrus; ; subiculum; ; primary motor cortex; ; Region I of hippocampus proper; ; nucleus accumbens; ; spermatocyte; ; endocardial cushion; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity ; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity ; hydrolase activity ; 3',5'-cyclic-nucleotide phosphodiesterase activity ; metal ion binding ; calmodulin binding ; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity ; cGMP binding ; 3',5'-cyclic-AMP phosphodiesterase activity ; 3',5'-cyclic-GMP phosphodiesterase activity ;
Cellular component	cytosol ; cytoplasm ; nucleus ; neuronal cell body ;
Biological process	cGMP catabolic process ; cAMP catabolic process ; signal transduction ; regulation of smooth muscle cell apoptotic process ; regulation of smooth muscle cell proliferation ; G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	5136
	18573
	ENSG00000115252
	ENSMUSG00000059173
	P54750 ; Q9Y633
	Q61481
NM_001003683 ; NM_001258312 ; NM_001258313 ; NM_001258314 ; NM_005019 ;
	NM_001363871 ; NM_001395258 ; NM_001395259 ; NM_001395260 ; NM_001395261 ; NM_001395262 ; NM_001395263 ; NM_001395264 ; NM_001395265 ; NM_001395266 ; NM_001395267 ; NM_001395268 ; NM_001395269
NM_001009978 ; NM_001009979 ; NM_001159582 ; NM_016744 ; NM_001355140 ;
	NM_001355141 ; NM_001355142 ; NM_001355143 ; NM_001355144
NP_001003683 ; NP_001245241 ; NP_001245242 ; NP_001245243 ; NP_005010 ;
	NP_001350800 ; NP_001245241.1
NP_001009978 ; NP_001009979 ; NP_001153054 ; NP_058024 ; NP_001342069 ;
	NP_001342070 ; NP_001342071 ; NP_001342073
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2024

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.^[5]^[6]^[7]

Related Research Articles

Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium- and calmodulin-dependent phosphodiesterase. It is one of the 11 families of phosphodiesterase (PDE1-PDE11). Phosphodiesterase 1 has three subtypes, PDE1A, PDE1B and PDE1C which divide further into various isoforms. The various isoforms exhibit different affinities for cAMP and cGMP.

Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene.

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.

Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene.

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene. Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.

Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein.

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene. Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.

Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene.

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene.

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.

2′,3′-Cyclic-nucleotide 3'-phosphodiesterase is an enzyme that in humans is encoded by the CNP gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115252 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059173 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi: 10.1074/jbc.271.2.796 . PMID 8557689.
↑ Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K (May 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim Biophys Acta. 1517 (2): 278–87. doi:10.1016/s0167-4781(00)00293-1. PMID 11342109.
↑ "Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Snyder PB, Florio VA, Ferguson K, Loughney K (1999). "Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A)". Cell. Signal. 11 (7): 535–44. doi:10.1016/S0898-6568(99)00027-3. PMID 10405764.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID 11156964. S2CID 26315564.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis". Biol. Reprod. 64 (6): 1746–54. doi: 10.1095/biolreprod64.6.1746 . PMID 11369604.
Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
Ritter M, Buechler C, Boettcher A, et al. (2002). "Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I". Genomics. 79 (5): 693–702. doi:10.1006/geno.2002.6761. PMID 11991719.
Lefièvre L, de Lamirande E, Gagnon C (2003). "Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa". Biol. Reprod. 67 (2): 423–30. doi: 10.1095/biolreprod67.2.423 . PMID 12135876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Goraya TA, Masada N, Ciruela A, Cooper DM (2004). "Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A". J. Biol. Chem. 279 (39): 40494–504. doi: 10.1074/jbc.M313441200 . PMID 15272012.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Nagel DJ, Aizawa T, Jeon KI, et al. (2006). "Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival". Circ. Res. 98 (6): 777–84. doi:10.1161/01.RES.0000215576.27615.fd. PMC 4114760 . PMID 16514069.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115252 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000059173 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8557689-5] Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796–806. doi: 10.1074/jbc.271.2.796 . PMID 8557689.

[pmid11342109-6] Michibata H, Yanaka N, Kanoh Y, Okumura K, Omori K (May 2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim Biophys Acta. 1517 (2): 278–87. doi:10.1016/s0167-4781(00)00293-1. PMID 11342109.

[entrez-7] "Entrez Gene: PDE1A phosphodiesterase 1A, calmodulin-dependent".

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PDE1A

Related Research Articles

References

Further reading