PDE1B

PDE1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TAZ, 4NPV, 4NPW, 5B25
Identifiers
Aliases	PDE1B , PDE1B1, PDES1B, HEL-S-79p, phosphodiesterase 1B
External IDs	OMIM: 171891 MGI: 97523 HomoloGene: 37370 GeneCards: PDE1B
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,579,239 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,438,479 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; gastric mucosa; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; ascending aorta; ; middle frontal gyrus; ; subcutaneous adipose tissue;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; superior frontal gyrus; ; globus pallidus; ; entorhinal cortex; ; superior colliculus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; inferior colliculus; ; pontine nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity ; metal ion binding ; calmodulin binding ; cyclic-nucleotide phosphodiesterase activity ; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity ; protein binding ; phosphoric diester hydrolase activity ; hydrolase activity ; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity ; 3',5'-cyclic-AMP phosphodiesterase activity ; 3',5'-cyclic-GMP phosphodiesterase activity ;
Cellular component	cytoplasm ; neuronal cell body ; cytosol ;
Biological process	visual learning ; regulation of neurotransmitter levels ; cAMP catabolic process ; locomotory behavior ; response to amphetamine ; serotonin metabolic process ; monocyte differentiation ; regulation of dopamine metabolic process ; cellular response to macrophage colony-stimulating factor stimulus ; cGMP catabolic process ; cellular response to granulocyte macrophage colony-stimulating factor stimulus ; apoptotic process ; signal transduction ; G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	5153
	18574
	ENSG00000123360
	ENSMUSG00000022489
	Q01064
	Q01065
NM_000924 ; NM_001165975 ; NM_001288768 ; NM_001288769 ; NM_001315534 ;
	NM_001315535
	NM_001285890 ; NM_008800 ; NM_001357980
NP_000915 ; NP_001159447 ; NP_001275697 ; NP_001275698 ; NP_001302463 ;
	NP_001302464
	NP_001272819 ; NP_032826 ; NP_001344909
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2024

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123360 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022489 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A. 93 (20): 11236–41. Bibcode:1996PNAS...9311236J. doi: 10.1073/pnas.93.20.11236 . PMC 1074519 . PMID 8855339.
↑ Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal. 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.
↑ "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

Repaske DR, Swinnen JV, Jin SL, et al. (1992). "A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase". J. Biol. Chem. 267 (26): 18683–8. doi: 10.1016/S0021-9258(19)37015-2 . PMID 1326532.
Spence S, Rena G, Sullivan M, et al. (1997). "Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase". Biochem. J. 321 ( Pt 1) (Pt 1): 157–63. doi:10.1042/bj3210157. PMC 1218050 . PMID 9003415.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID 11156964. S2CID 26315564.
Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Bender AT, Ostenson CL, Wang EH, Beavo JA (2005). "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 497–502. Bibcode:2005PNAS..102..497B. doi: 10.1073/pnas.0408535102 . PMC 544304 . PMID 15625104.
Bender AT, Beavo JA (2006). "PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 460–5. Bibcode:2006PNAS..103..460B. doi: 10.1073/pnas.0509972102 . PMC 1326187 . PMID 16407168.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123360 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022489 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8855339-5] Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A. 93 (20): 11236–41. Bibcode:1996PNAS...9311236J. doi: 10.1073/pnas.93.20.11236 . PMC 1074519 . PMID 8855339.

[pmid9419816-6] Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal. 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.

[entrez-7] "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

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PDE1B

Related Research Articles

References

Further reading