PDE2A

PDE2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB
Identifiers
Aliases	PDE2A , CGS-PDE, PDE2A1, PED2A4, cGSPDE, phosphodiesterase 2A, IDDPADS
External IDs	OMIM: 602658 MGI: 2446107 HomoloGene: 1952 GeneCards: PDE2A
Gene location (Human)
Chr.	Chromosome 11 (human)
End	72,674,591 bp
RNA expression pattern
	Top expressed in
	spleen; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; Brodmann area 9; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; nucleus accumbens; ; subcutaneous adipose tissue; ; putamen;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; 3',5'-cyclic-nucleotide phosphodiesterase activity ; calcium channel activity ; cGMP binding ; metal ion binding ; cyclic-nucleotide phosphodiesterase activity ; protein binding ; phosphoric diester hydrolase activity ; TPR domain binding ; hydrolase activity ; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity ; cAMP binding ; protein homodimerization activity ; 3',5'-cyclic-AMP phosphodiesterase activity ; 3',5'-cyclic-GMP phosphodiesterase activity ; identical protein binding ; magnesium ion binding ; zinc ion binding ; phosphate ion binding ;
Cellular component	cytoplasm ; cytosol ; Golgi apparatus ; membrane ; plasma membrane ; endoplasmic reticulum ; mitochondrion ; perinuclear region of cytoplasm ; presynaptic membrane ; nucleus ; mitochondrial outer membrane ; mitochondrial inner membrane ; mitochondrial matrix ;
Biological process	establishment of endothelial barrier ; cellular response to transforming growth factor beta stimulus ; positive regulation of inflammatory response ; cellular response to cGMP ; negative regulation of transcription by RNA polymerase II ; monocyte differentiation ; cGMP-mediated signaling ; cellular response to macrophage colony-stimulating factor stimulus ; cellular response to mechanical stimulus ; positive regulation of vascular permeability ; cellular response to granulocyte macrophage colony-stimulating factor stimulus ; cAMP-mediated signaling ; signal transduction ; negative regulation of vascular permeability ; cGMP catabolic process ; cAMP catabolic process ; calcium ion transmembrane transport ; G protein-coupled receptor signaling pathway ; negative regulation of cAMP-mediated signaling ; cellular response to cAMP ; cellular response to 2,3,7,8-tetrachlorodibenzodioxine ; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ; positive regulation of gene expression ; negative regulation of cGMP-mediated signaling ; regulation of mitochondrion organization ; heart valve development ; ventricular septum development ; aorta development ;
	Sources:Amigo / QuickGO
Orthologs
	5138
	207728
	ENSG00000186642
	ENSMUSG00000030653
	O00408
	Q922S4
	NM_001143839 ; NM_001146209 ; NM_001243784 ; NM_002599
	NM_001008548 ; NM_001143848 ; NM_001143849 ; NM_001243757 ; NM_001243758
	NP_001137311 ; NP_001139681 ; NP_001230713 ; NP_002590
	NP_001008548 ; NP_001137320 ; NP_001137321 ; NP_001230686 ; NP_001230687
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 28, 2024

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.^[4]^[5]

Related Research Articles

The PDE2 enzyme is one of 21 different phosphodiesterases (PDE) found in mammals. These different PDEs can be subdivided to 11 families. The different PDEs of the same family are functionally related despite the fact that their amino acid sequences show considerable divergence. The PDEs have different substrate specificities. Some are cAMP selective hydrolases, others are cGMP selective hydrolases and the rest can hydrolyse both cAMP and cGMP.

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene.

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.

Guanine nucleotide-binding protein G(t) subunit alpha-2 is a protein that in humans is encoded by the GNAT2 gene.

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene. RAP2B belongs to the Ras-related protein family.

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A is an enzyme that in humans is encoded by the PDE1A gene.

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene. Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene.

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A is an enzyme that in humans is encoded by the PDE9A gene.

mRNA-capping enzyme is a protein that in humans is encoded by the RNGTT gene.

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene. Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene.

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' is an enzyme that in humans is encoded by the PDE6C gene.

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.

Potassium voltage-gated channel subfamily F member 1 is a protein that in humans is encoded by the KCNF1 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit.

PDE7B is a mammalian gene that encodes a 3'5'-cyclic nucleotide phosphodiesterase (PDE) that converts 3'5'-cyclic adenosine monophosphate (cAMP) to 5'AMP as part of cyclic nucleotide signaling pathways. There are 21 PDE genes in mammals that are pharmacologically-grouped into 11 families based on their biochemical characteristics and sequence conservation. The PDE7 family is composed of PDEs encoded by two genes, PDE7A and PDE7B. These PDEs are highly specific for cAMP relative to cGMP.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186642 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.
↑ "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, Van Laak V (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. 37 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892. S2CID 1060183.
Seybold J, Thomas D, Witzenrath M, Boral S, Hocke AC, Bürger A, Hatzelmann A, Tenor H, Schudt C (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood. 105 (9): 3569–3576. doi: 10.1182/blood-2004-07-2729 . PMID 15650061.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. Bibcode:2002PNAS...9913260M. doi: 10.1073/pnas.192374899 . PMC 130621 . PMID 12271124.
Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. doi:10.1055/s-0037-1613099. PMID 12038792. S2CID 4637804.
Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi: 10.1096/fj.00-0354com . PMID 11156964. S2CID 26315564.
Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi: 10.1177/002215549904700707 . PMID 10375378.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186642 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9210593-4] Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.

[entrez-5] "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

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PDE2A

Related Research Articles

References

Further reading