PDE8B

PDE8B
Identifiers
Aliases	PDE8B , ADSD, PPNAD3, phosphodiesterase 8B
External IDs	OMIM: 603390 MGI: 2443999 HomoloGene: 2758 GeneCards: PDE8B
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	95,386,844 bp
RNA expression pattern
	n/a
	Top expressed in
	olfactory tubercle; ; superior frontal gyrus; ; ventromedial nucleus; ; pineal gland; ; nucleus accumbens; ; piriform cortex; ; Region I of hippocampus proper; ; toe; ; supraoptic nucleus; ; primary motor cortex;
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity ; hydrolase activity ; 3',5'-cyclic-nucleotide phosphodiesterase activity ; metal ion binding ; 3',5'-cyclic-AMP phosphodiesterase activity ;
Cellular component	cytosol ; cellular component ;
Biological process	cyclic nucleotide metabolic process ; cAMP catabolic process ; signal transduction ; G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	8622
	218461
	ENSG00000113231
	ENSMUSG00000021684
	O95263
	E9Q4S1
NM_001029851 ; NM_001029852 ; NM_001029853 ; NM_001029854 ; NM_003719 ;
	NM_001349748 ; NM_001349749 ; NM_001349750 ; NM_001349751 ; NM_001349752 ; NM_001349753
NM_001170669 ; NM_172263 ; NM_001346782 ; NM_001374003 ; NM_001374004 ;
	NM_001374005 ; NM_001374006 ; NM_001374007
NP_001025022 ; NP_001025023 ; NP_001025024 ; NP_001025025 ; NP_003710 ;
	NP_001336677 ; NP_001336678 ; NP_001336679 ; NP_001336680 ; NP_001336681 ; NP_001336682 ; NP_001362991 ; NP_001362992 ; NP_001362993 ; NP_001362994 ; NP_001362995 ; NP_001362996 ; NP_001362997 ; NP_001362998 ; NP_001362999 ; NP_001363000 ; NP_001363001 ; NP_001363002 ; NP_001363003 ; NP_001363004
NP_001164140 ; NP_001333711 ; NP_758467 ; NP_001360932 ; NP_001360933 ;
	NP_001360934 ; NP_001360935 ; NP_001360936 ; NP_001391617 ; NP_001391618 ; NP_001391619 ; NP_001391620 ; NP_001391621 ; NP_001391622 ; NP_001391623 ; NP_001391624 ; NP_001391625
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 30, 2023

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.^[4]^[5]

Related Research Articles

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References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021684 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hayashi M, Matsushima K, Ohashi H, Tsunoda H, Murase S, Kawarada Y, Tanaka T (Nov 1998). "Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase". Biochem Biophys Res Commun. 250 (3): 751–6. doi:10.1006/bbrc.1998.9379. PMID 9784418.
↑ "Entrez Gene: PDE8B phosphodiesterase 8B".

Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Persani L, Borgato S, Lania A, et al. (2001). "Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations". J. Clin. Endocrinol. Metab. 86 (8): 3795–800. doi: 10.1210/jcem.86.8.7779 . PMID 11502813.
Hayashi M, Shimada Y, Nishimura Y, et al. (2002). "Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene". Biochem. Biophys. Res. Commun. 297 (5): 1253–8. doi:10.1016/S0006-291X(02)02371-9. PMID 12372422.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–74. doi:10.1016/S0898-6568(02)00146-8. PMID 12681444.
Pérez-Torres S, Cortés R, Tolnay M, et al. (2003). "Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization". Exp. Neurol. 182 (2): 322–34. doi:10.1016/S0014-4886(03)00042-6. hdl: 10261/112629 . PMID 12895443. S2CID 12150443.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021684 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9784418-4] Hayashi M, Matsushima K, Ohashi H, Tsunoda H, Murase S, Kawarada Y, Tanaka T (Nov 1998). "Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase". Biochem Biophys Res Commun. 250 (3): 751–6. doi:10.1006/bbrc.1998.9379. PMID 9784418.

[entrez-5] "Entrez Gene: PDE8B phosphodiesterase 8B".

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PDE8B

Related Research Articles

References

Further reading