PDE8B

PDE8B
Identifiers
Aliases	PDE8B , ADSD, PPNAD3, phosphodiesterase 8B
External IDs	OMIM: 603390; MGI: 2443999; HomoloGene: 2758; GeneCards: PDE8B; OMA:PDE8B - orthologs
Gene location (Mouse) Chr. Chromosome 13 (mouse) [1] Band 13|13 D1 Start 95,160,962 bp [1] End 95,386,844 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in olfactory tubercle superior frontal gyrus ventromedial nucleus pineal gland nucleus accumbens piriform cortex Region I of hippocampus proper posterior nasal aperture toe neural layer of retina BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding 3',5'-cyclic-AMP phosphodiesterase activity Cellular component cytosol cellular component Biological process cyclic nucleotide metabolic process cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8622 218461 Ensembl ENSG00000113231 ENSMUSG00000021684 UniProt O95263 E9Q4S1 RefSeq (mRNA) NM_001029851 NM_001029852 NM_001029853 NM_001029854 NM_003719 NM_001349748 NM_001349749 NM_001349750 NM_001349751 NM_001349752 NM_001349753 NM_001170669 NM_172263 NM_001346782 NM_001374003 NM_001374004 NM_001374005 NM_001374006 NM_001374007 RefSeq (protein) NP_001025022 NP_001025023 NP_001025024 NP_001025025 NP_003710 NP_001336677 NP_001336678 NP_001336679 NP_001336680 NP_001336681 NP_001336682 NP_001362991 NP_001362992 NP_001362993 NP_001362994 NP_001362995 NP_001362996 NP_001362997 NP_001362998 NP_001362999 NP_001363000 NP_001363001 NP_001363002 NP_001363003 NP_001363004 NP_001164140 NP_001333711 NP_758467 NP_001360932 NP_001360933 NP_001360934 NP_001360935 NP_001360936 NP_001391617 NP_001391618 NP_001391619 NP_001391620 NP_001391621 NP_001391622 NP_001391623 NP_001391624 NP_001391625 Location (UCSC) n/a Chr 13: 95.16 – 95.39 Mb PubMed search [2] [3]
Wikidata
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene. ^{[4] [5]}

Clinical significance

PDE8B expression has been linked to higher survival rates for lung adenocarcinoma patients. ^[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000021684 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Hayashi M, Matsushima K, Ohashi H, Tsunoda H, Murase S, Kawarada Y, Tanaka T (Nov 1998). "Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase". Biochem Biophys Res Commun. 250 (3): 751–6. doi:10.1006/bbrc.1998.9379. PMID   9784418.
5. "Entrez Gene: PDE8B phosphodiesterase 8B".
6. "Research update from the MCM team (May 2025)". World Community Grid. 21 May 2025. Retrieved 22 May 2025.

Further reading

• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Persani L, Borgato S, Lania A, et al. (2001). "Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations". J. Clin. Endocrinol. Metab. 86 (8): 3795–800. doi: 10.1210/jcem.86.8.7779 . PMID   11502813.
• Hayashi M, Shimada Y, Nishimura Y, et al. (2002). "Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene". Biochem. Biophys. Res. Commun. 297 (5): 1253–8. doi:10.1016/S0006-291X(02)02371-9. PMID   12372422.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–74. doi:10.1016/S0898-6568(02)00146-8. PMID   12681444.
• Pérez-Torres S, Cortés R, Tolnay M, et al. (2003). "Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization". Exp. Neurol. 182 (2): 322–34. doi:10.1016/S0014-4886(03)00042-6. hdl: 10261/112629 . PMID   12895443. S2CID   12150443.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.