PECI (gene)

ECI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQU, 2F6Q, 4U18, 4U19, 4U1A
Identifiers
Aliases	ECI2 , ACBD2, DRS-1, DRS1, HCA88, PECI, dJ1013A10.3, enoyl-CoA delta isomerase 2
External IDs	OMIM: 608024 MGI: 1346064 HomoloGene: 38145 GeneCards: ECI2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	4,135,597 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	35,211,079 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right ventricle; ; triceps brachii muscle; ; left adrenal gland; ; biceps brachii; ; left ventricle; ; thoracic diaphragm; ; body of pancreas; ; right lobe of liver; ; kidney;
	Top expressed in
	saccule; ; otic placode; ; renal corpuscle; ; interventricular septum; ; proximal tubule; ; hair follicle; ; ureter; ; external carotid artery; ; endocardial cushion; ; liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	intramolecular oxidoreductase activity, transposing C=C bonds ; signaling receptor binding ; catalytic activity ; isomerase activity ; fatty-acyl-CoA binding ; dodecenoyl-CoA delta-isomerase activity ;
Cellular component	membrane ; mitochondrion ; intracellular membrane-bounded organelle ; nucleoplasm ; peroxisomal matrix ; peroxisome ; cytosol ;
Biological process	fatty acid catabolic process ; fatty acid beta-oxidation ; metabolism ; fatty acid beta-oxidation using acyl-CoA oxidase ; protein targeting to peroxisome ;
	Sources:Amigo / QuickGO
Orthologs
	10455
	23986
	ENSG00000198721
	ENSMUSG00000021417
	O75521
	Q9WUR2
	NM_001166010 ; NM_006117 ; NM_206836
	NM_001110331 ; NM_001110332 ; NM_011868
	NP_001159482 ; NP_006108 ; NP_996667
	NP_001103801 ; NP_035998
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Peroxisomal 3,2-trans-enoyl-CoA isomerase is an enzyme that in humans is encoded by the PECI gene.^[5]^[6]

PECI is an auxiliary enzyme that catalyzes an isomerization step required for the beta-oxidation of unsaturated fatty acids.[supplied by OMIM]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198721 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021417 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Geisbrecht BV, Zhang D, Schulz H, Gould SJ (Aug 1999). "Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes". J Biol Chem. 274 (31): 21797–803. doi: 10.1074/jbc.274.31.21797 . PMID 10419495.
1 2 "Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Suk K, Kim YH, Hwang DY, et al. (1999). "Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor". Biochim. Biophys. Acta. 1454 (1): 126–31. doi:10.1016/s0925-4439(99)00033-2. PMID 10354522.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086 . PMID 11337467.
Janssen U, Stoffel W (2002). "Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse". J. Biol. Chem. 277 (22): 19579–84. doi: 10.1074/jbc.M110993200 . PMID 11916962.
Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi: 10.4049/jimmunol.169.2.1102 . PMID 12097419.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Feng X, Chuhjo T, Sugimori C, et al. (2004). "Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells". Blood. 104 (8): 2425–31. doi: 10.1182/blood-2004-05-1839 . PMID 15217832.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198721 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021417 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10419495-5] Geisbrecht BV, Zhang D, Schulz H, Gould SJ (Aug 1999). "Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes". J Biol Chem. 274 (31): 21797–803. doi: 10.1074/jbc.274.31.21797 . PMID 10419495.

[entrez-6] 1 2 "Entrez Gene: PECI peroxisomal D3,D2-enoyl-CoA isomerase".

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PECI (gene)

Related Research Articles

References

Further reading