PECR

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PECR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YXM
Identifiers
Aliases	PECR , DCRRP, HPDHASE, HSA250303, PVIARL, SDR29C1, TERP, peroxisomal trans-2-enoyl-CoA reductase
External IDs	OMIM: 605843; MGI: 2148199; HomoloGene: 69255; GeneCards: PECR; OMA:PECR - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q35 Start 215,996,329 bp [1] End 216,082,955 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 C3|1 36.46 cM Start 72,298,326 bp [2] End 72,323,473 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla buccal mucosa cell nipple ventral tegmental area synovial joint cardia trigeminal ganglion subthalamic nucleus external globus pallidus spinal ganglia Top expressed in right kidney human kidney left lobe of liver zygote primary oocyte proximal tubule secondary oocyte lacrimal gland parotid gland epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity signaling receptor binding 2,4-dienoyl-CoA reductase (NADPH) activity trans-2-enoyl-CoA reductase (NADPH) activity Cellular component peroxisome mitochondrion peroxisomal membrane cytosol Biological process phytol metabolic process fatty acid biosynthetic process fatty acid metabolic process lipid metabolism fatty acid alpha-oxidation protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55825 111175 Ensembl ENSG00000115425 ENSMUSG00000026189 UniProt Q9BY49 Q99MZ7 RefSeq (mRNA) NM_018441 NM_023523 NM_001356516 RefSeq (protein) NP_060911 NP_076012 NP_001343445 Location (UCSC) Chr 2: 216 – 216.08 Mb Chr 1: 72.3 – 72.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal trans-2-enoyl-CoA reductase is an enzyme that in humans is encoded by the PECR gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000115425 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026189 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Das AK, Uhler MD, Hajra AK (Sep 2000). "Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs". J Biol Chem. 275 (32): 24333–40. doi: 10.1074/jbc.M001168200 . PMID   10811639.
6. Amery L, Mannaerts GP, Subramani S, et al. (Oct 2001). "Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology". Comb Chem High Throughput Screen. 4 (7): 545–52. doi:10.2174/1386207013330832. PMID   11669066.
7. Persson B, Kallberg Y, Bray JE, et al. (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
8. "Entrez Gene: PECR peroxisomal trans-2-enoyl-CoA reductase".

Further reading

• Gay F, Anglade I, Gong Z, et al. (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Mol. Endocrinol. 14 (10): 1627–48. doi: 10.1210/mend.14.10.0538 . PMID   11043578.
• Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID   11827452.
• Braastad CD, Leguia M, Hendrickson EA (2002). "Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element". Nucleic Acids Res. 30 (8): 1713–24. doi:10.1093/nar/30.8.1713. PMC   113227 . PMID   11937624.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Gloerich J, Ruiter JP, van den Brink DM, et al. (2006). "Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation". FEBS Lett. 580 (8): 2092–6. doi: 10.1016/j.febslet.2006.03.011 . PMID   16546181. S2CID   34148550.