PGM5

PGM5
Identifiers
Aliases	PGM5 , PGMRP, phosphoglucomutase 5
External IDs	OMIM: 600981 MGI: 1925668 HomoloGene: 74881 GeneCards: PGM5
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	24,839,219 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; seminal vesicula; ; gastric mucosa; ; urethra; ; vena cava; ; left uterine tube; ; popliteal artery; ; right ventricle; ; nipple; ; right coronary artery;
	Top expressed in
	interventricular septum; ; otolith organ; ; utricle; ; atrium; ; myocardium of ventricle; ; uterus; ; aorta; ; ascending aorta; ; left colon; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	intramolecular transferase activity, phosphotransferases ; structural molecule activity ; metal ion binding ; phosphoglucomutase activity ; magnesium ion binding ;
Cellular component	cytoplasm ; cytosol ; intercalated disc ; focal adhesion ; cell-substrate junction ; adherens junction ; dystrophin-associated glycoprotein complex ; stress fiber ; cell junction ; spot adherens junction ; Z disc ; cytoplasmic side of plasma membrane ; sarcolemma ; costamere ; cytoskeleton ;
Biological process	organic substance metabolic process ; cell adhesion ; glycogen biosynthetic process ; glucose metabolic process ; galactose catabolic process ; carbohydrate metabolic process ; striated muscle tissue development ; myofibril assembly ;
	Sources:Amigo / QuickGO
Orthologs
	5239
	226041
	n/a
	ENSMUSG00000041731
	Q15124
	Q8BZF8
	NM_021965
	NM_175013
	NP_068800
	NP_778178
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 14, 2023

Phosphoglucomutase-like protein 5 is an enzyme that in humans is encoded by the PGM5 gene.^[4]^[5]^[6]

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Phosphoglucomutase-1 is an enzyme that in humans is encoded by the PGM1 gene. The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red blood cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause CDG syndrome type 1t. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]

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References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041731 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Edwards YH, Putt W, Fox M, Ives JH (Mar 1996). "A novel human phosphoglucomutase (PGM5) maps to the centromeric region of chromosome 9". Genomics. 30 (2): 350–3. doi:10.1006/geno.1995.9866. PMID 8586438.
↑ Moiseeva EP, Belkin AM, Spurr NK, Koteliansky VE, Critchley DR (Jul 1996). "A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily". Eur J Biochem. 235 (1–2): 103–13. doi: 10.1111/j.1432-1033.1996.00103.x . PMID 8631316.
↑ "Entrez Gene: PGM5 phosphoglucomutase 5".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wakayama Y, Inoue M, Kojima H, et al. (2000). "Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles". Acta Neuropathol. 99 (6): 654–62. doi:10.1007/s004010051176. PMID 10867799. S2CID 20949507.
Moiseeva EP, Critchley DR (1997). "Characterisation of the promoter which regulates expression of a phosphoglucomutase-related protein, a component of the dystrophin/utrophin cytoskeleton predominantly expressed in smooth muscle". Eur. J. Biochem. 248 (3): 634–43. doi:10.1111/j.1432-1033.1997.00634.x. PMID 9342213.
Belkin AM, Klimanskaya IV, Lukashev ME, et al. (1994). "A novel phosphoglucomutase-related protein is concentrated in adherens junctions of muscle and nonmuscle cells". J. Cell Sci. 107 (1): 159–73. doi:10.1242/jcs.107.1.159. PMID 8175905.
Belkin AM, Burridge K (1995). "Association of aciculin with dystrophin and utrophin". J. Biol. Chem. 270 (11): 6328–37. doi: 10.1074/jbc.270.11.6328 . PMID 7890770.
Belkin AM, Burridge K (1995). "Localization of utrophin and aciculin at sites of cell-matrix and cell-cell adhesion in cultured cells". Exp. Cell Res. 221 (1): 132–40. doi:10.1006/excr.1995.1360. PMID 7589238.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041731 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586438-4] Edwards YH, Putt W, Fox M, Ives JH (Mar 1996). "A novel human phosphoglucomutase (PGM5) maps to the centromeric region of chromosome 9". Genomics. 30 (2): 350–3. doi:10.1006/geno.1995.9866. PMID 8586438.

[pmid8631316-5] Moiseeva EP, Belkin AM, Spurr NK, Koteliansky VE, Critchley DR (Jul 1996). "A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily". Eur J Biochem. 235 (1–2): 103–13. doi: 10.1111/j.1432-1033.1996.00103.x . PMID 8631316.

[entrez-6] "Entrez Gene: PGM5 phosphoglucomutase 5".

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PGM5

Related Research Articles

References

Further reading