PHACTR3

PHACTR3
Identifiers
Aliases	PHACTR3 , C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
External IDs	OMIM: 608725; MGI: 1921439; HomoloGene: 14482; GeneCards: PHACTR3; OMA:PHACTR3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.32-q13.33 Start 59,577,509 bp [1] End 59,847,711 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H4 Start 177,760,768 bp [2] End 177,980,285 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala internal globus pallidus C1 segment substantia nigra corpus callosum cingulate gyrus anterior cingulate cortex right frontal lobe Brodmann area 9 hippocampus proper Top expressed in piriform cortex olfactory tubercle superior frontal gyrus cingulate gyrus globus pallidus superior cervical ganglion temporal lobe visual cortex primary motor cortex hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function protein phosphatase inhibitor activity protein phosphatase 1 binding actin binding protein phosphatase regulator activity Cellular component nuclear matrix nucleus nucleoplasm Biological process negative regulation of phosphoprotein phosphatase activity regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116154 74189 Ensembl ENSG00000087495 ENSMUSG00000027525 UniProt Q96KR7 Q8BYK5 RefSeq (mRNA) NM_001199505 NM_001199506 NM_001281507 NM_080672 NM_183244 NM_183246 NM_001007154 NM_001177789 NM_001177790 NM_001177791 NM_028806 RefSeq (protein) NP_001186434 NP_001186435 NP_001268436 NP_542403 NP_899067 NP_899069 NP_001007155 NP_001171260 NP_001171261 NP_001171262 NP_083082 Location (UCSC) Chr 20: 59.58 – 59.85 Mb Chr 2: 177.76 – 177.98 Mb PubMed search [3] [4]
Wikidata
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Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene. ^{[5] [6]}

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms. ^[6]

Interactions

PHACTR3 has been shown to interact with PPP1CA. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000087495 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027525 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. Bibcode:2004PNAS..101.7187A. doi: 10.1073/pnas.0401673101 . PMC   406487 . PMID   15107502.
6. "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
7. Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi: 10.1074/jbc.M305227200 . PMID   12925532.

Further reading

• Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human". Cytogenet. Genome Res. 115 (1): 23–9. doi:10.1159/000094797. PMID   16974080. S2CID   38349132.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi: 10.1074/jbc.M305227200 . PMID   12925532.