PHACTR3

PHACTR3
Identifiers
Aliases	PHACTR3 , C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
External IDs	OMIM: 608725 MGI: 1921439 HomoloGene: 14482 GeneCards: PHACTR3
Gene location (Human)
Chr.	Chromosome 20 (human)
End	59,847,711 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	177,980,285 bp
RNA expression pattern
	Top expressed in
	amygdala; ; internal globus pallidus; ; substantia nigra; ; corpus callosum; ; cingulate gyrus; ; Brodmann area 9; ; hippocampus proper; ; putamen; ; ganglionic eminence; ; hypothalamus;
	Top expressed in
	piriform cortex; ; olfactory tubercle; ; superior frontal gyrus; ; cingulate gyrus; ; globus pallidus; ; superior cervical ganglion; ; temporal lobe; ; visual cortex; ; primary motor cortex; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein phosphatase inhibitor activity ; protein phosphatase 1 binding ; actin binding ; protein phosphatase regulator activity ;
Cellular component	nuclear matrix ; nucleus ; nucleoplasm ;
Biological process	negative regulation of phosphoprotein phosphatase activity ; regulation of phosphoprotein phosphatase activity ;
	Sources:Amigo / QuickGO
Orthologs
	116154
	74189
	ENSG00000087495
	ENSMUSG00000027525
	Q96KR7
	Q8BYK5
NM_001199505 ; NM_001199506 ; NM_001281507 ; NM_080672 ; NM_183244 ;
	NM_183246
	NM_001007154 ; NM_001177789 ; NM_001177790 ; NM_001177791 ; NM_028806 Contents Function ; Interactions ; References ; Further reading ;
NP_001186434 ; NP_001186435 ; NP_001268436 ; NP_542403 ; NP_899067 ;
	NP_899069
	NP_001007155 ; NP_001171260 ; NP_001171261 ; NP_001171262 ; NP_083082
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.^[5]^[6]

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.^[6]

Interactions

PHACTR3 has been shown to interact with PPP1CA.^[7]

Related Research Articles

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that is encoded by the PPP2CA gene.

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene. Mutations in PPP2R5D cause Jordan's Syndrome.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.

Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene.

T-complex protein 1 subunit delta is a protein that in humans is encoded by the CCT4 gene. The CCT4 protein is a component of the TRiC complex.

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.

Neurabin-1 is a protein that in humans is encoded by the PPP1R9A gene.

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the PPP2R3B gene.

Protein phosphatase 1 regulatory subunit 7 is an enzyme that in humans is encoded by the PPP1R7 gene.

Phosphatase and actin regulator 1 (PHACTR1) is a protein that in humans is encoded by the PHACTR1 gene on chromosome 6. It is most significantly expressed in the globus pallidus of the brain. PHACTR1 is an actin and protein phosphatase 1 (PP1) binding protein that binds actin and regulates the reorganization of the actin cytoskeleton. This protein has been associated with coronary artery disease and migraines through genome-wide association studies. The PHACTR1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

Protein phosphatase 1 regulatory subunit 12C is a protein that in humans is encoded by the PPP1R12C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000087495 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027525 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. Bibcode:2004PNAS..101.7187A. doi: 10.1073/pnas.0401673101 . PMC 406487 . PMID 15107502.
1 2 "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
↑ Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi: 10.1074/jbc.M305227200 . PMID 12925532.

PHACTR3

Contents

Function

Interactions

Related Research Articles

References

Further reading