PHLPP (gene)

PHLPP1
Identifiers
Aliases	PHLPP1 , PHLPP, PLEKHE1, SCOP, PPM3A, PH domain and leucine rich repeat protein phosphatase 1
External IDs	OMIM: 609396 MGI: 2138327 HomoloGene: 11015 GeneCards: PHLPP1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	62,980,433 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	106,321,980 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; middle frontal gyrus; ; inferior ganglion of vagus nerve; ; optic nerve; ; ganglionic eminence; ; Region I of hippocampus proper; ; external globus pallidus; ; subthalamic nucleus; ; Brodmann area 10;
	Top expressed in
	lateral geniculate nucleus; ; globus pallidus; ; substantia nigra; ; medial geniculate nucleus; ; pontine nuclei; ; dorsal tegmental nucleus; ; medial dorsal nucleus; ; mammillary body; ; superior colliculus; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity ; metal ion binding ; protein binding ; catalytic activity ; hydrolase activity ; protein serine/threonine phosphatase activity ;
Cellular component	cytosol ; membrane ; nucleus ; cytoplasm ; plasma membrane ; nuclear membrane ; photoreceptor inner segment ; photoreceptor outer segment membrane ;
Biological process	regulation of apoptotic process ; regulation of MAPK cascade ; protein dephosphorylation ; entrainment of circadian clock ; regulation of JNK cascade ; regulation of T cell anergy ; regulation of p38MAPK cascade ; apoptotic process ; regulation of protein kinase C signaling ; negative regulation of protein kinase B signaling ;
	Sources:Amigo / QuickGO
Orthologs
	23239
	98432
	ENSG00000081913
	ENSMUSG00000044340
	O60346
	Q8CHE4
	NM_194449
	NM_133821
	NP_919431
	NP_598582
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.^[5]

Related Research Articles

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene. The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding. DNM3 is upregulated in Sézary's syndrome.

Chloride transport protein 6 is a protein that in humans is encoded by the CLCN6 gene.

PHD finger protein 3 is a protein that in humans is encoded by the PHF3 gene.

RNA-binding protein 12 is a protein that in humans is encoded by the RBM12 gene.

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.

Pleckstrin homology domain-containing family A member 5 is a protein that in humans is encoded by the PLEKHA5 gene.

PERQ amino acid-rich with GYF domain-containing protein 2 is a protein that in humans is encoded by the GIGYF2 gene.

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.

PH domain and leucine rich repeat protein phosphatase-like, also known as PHLPPL, is an enzyme which in humans is encoded by the PHLPPL gene.

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.

TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene.

Tyrosine-protein phosphatase non-receptor type 23 is an enzyme that in humans is encoded by the PTPN23 gene.

Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene.

Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene.

Ubiquitin carboxyl-terminal hydrolase 34 is an enzyme that in humans is encoded by the USP34 gene.

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of cyclin-dependent kinase protein family.

Girdin is a protein that in humans is encoded by the CCDC88A gene. Although its cellular function are not fully elucidated, it has been associated with glioma.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000081913 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044340 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID 9628581.
Shimizu K, Okada M, Takano A, Nagai K (2000). "SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus". FEBS Lett. 458 (3): 363–9. doi: 10.1016/S0014-5793(99)01190-4 . PMID 10570941. S2CID 38044717.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Gao T, Furnari F, Newton AC (2005). "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth". Mol. Cell. 18 (1): 13–24. doi: 10.1016/j.molcel.2005.03.008 . PMID 15808505.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID 15951569.
Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5. doi: 10.1038/nature03983 . PMID 16177791.
Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms". Mol. Cell. 25 (6): 917–31. doi: 10.1016/j.molcel.2007.02.017 . PMID 17386267.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000081913 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044340 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase".

[1]

[2]

[3]

[4]

[5]

PHLPP (gene)

Contents

See also

Related Research Articles

References

Further reading