PHPT1

PHPT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AI6, 2HW4, 2NMM, 2OZW, 2OZX
Identifiers
Aliases	PHPT1 , CGI-202, HEL-S-132P, HSPC141, PHP14, phosphohistidine phosphatase 1, PHP
External IDs	OMIM: 610167 MGI: 1922704 HomoloGene: 8573 GeneCards: PHPT1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,851,027 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,465,236 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; Right adrenal gland; ; body of pancreas; ; right lobe of thyroid gland; ; right uterine tube; ; gastrocnemius muscle; ; left lobe of thyroid gland; ; cingulate gyrus; ; Brodmann area 9; ; left coronary artery;
	Top expressed in
	mirror; ; yolk sac; ; quadriceps femoris muscle; ; neural tube; ; cerebellum; ; olfactory bulb; ; muscle tissue; ; cerebellar cortex; ; skeletal muscle tissue; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel inhibitor activity ; phosphoprotein phosphatase activity ; hydrolase activity ; transmembrane transporter binding ; protein binding ; protein histidine phosphatase activity ;
Cellular component	cytoplasm ; cytosol ; extracellular exosome ;
Biological process	negative regulation of lyase activity ; positive regulation of insulin secretion involved in cellular response to glucose stimulus ; protein dephosphorylation ; regulation of actin cytoskeleton reorganization ; peptidyl-histidine dephosphorylation ; negative regulation of ATP citrate synthase activity ; positive regulation of cell motility ; negative regulation of T cell receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	29085
	75454
	ENSG00000054148
	ENSMUSG00000036504
	Q9NRX4
	Q9DAK9
	NM_001135860 ; NM_001135861 ; NM_001287342 ; NM_001287343 ; NM_014172
	NM_029293
	NP_001129333 ; NP_001274271 ; NP_001274272 ; NP_054891
	NP_083569
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

14 kDa phosphohistidine phosphatase is an enzyme that in humans is encoded by the PHPT1 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000054148 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036504 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
↑ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
↑ "Entrez Gene: PHPT1 phosphohistidine phosphatase 1".

Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC 16901 . PMID 10931946.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Lai CH, Chiu JY, Lin W (2001). "Identification of the human crooked neck gene by comparative gene identification". Biochim. Biophys. Acta. 1517 (3): 449–54. doi:10.1016/s0167-4781(00)00295-5. PMID 11342225.
Ek P, Pettersson G, Ek B, et al. (2002). "Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase". Eur. J. Biochem. 269 (20): 5016–23. doi:10.1046/j.1432-1033.2002.03206.x. PMID 12383260.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ma R, Kanders E, Sundh UB, et al. (2005). "Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity". Biochem. Biophys. Res. Commun. 337 (3): 887–91. doi:10.1016/j.bbrc.2005.09.134. PMID 16219293.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000054148 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036504 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.

[pmid8619474-6] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[entrez-7] "Entrez Gene: PHPT1 phosphohistidine phosphatase 1".

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PHPT1

Related Research Articles

References

Further reading