PI4K2B

PI4K2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WTV
Identifiers
Aliases	PI4K2B , PI4KIIB, PIK42B, phosphatidylinositol 4-kinase type 2 beta
External IDs	OMIM: 612101; MGI: 1914323; HomoloGene: 32405; GeneCards: PI4K2B; OMA:PI4K2B - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p15.2 Start 25,160,663 bp [1] End 25,279,204 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 C1 Start 52,898,916 bp [2] End 52,926,682 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa duodenum skin of arm mucosa of ileum epithelium of nasopharynx liver pancreatic epithelial cell mucosa of paranasal sinus rectum Top expressed in left lung lobe lacrimal gland decidua epithelium of small intestine gastrula parotid gland jejunum intestinal villus right lung crypt of lieberkuhn of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding ATP binding kinase activity 1-phosphatidylinositol 4-kinase activity Cellular component cytosol membrane cytoplasm lysosomal membrane endosome trans-Golgi network plasma membrane Biological process phosphatidylinositol biosynthetic process phosphorylation Golgi organization endosome organization phosphatidylinositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55300 67073 Ensembl ENSG00000038210 ENSMUSG00000029186 UniProt Q8TCG2 Q8CBQ5 RefSeq (mRNA) NM_018323 NM_025951 NM_028744 RefSeq (protein) NP_060793 NP_080227 NP_083020 Location (UCSC) Chr 4: 25.16 – 25.28 Mb Chr 5: 52.9 – 52.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol 4-kinase type 2-beta is an enzyme that in humans is encoded by the PI4K2B gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000038210 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029186 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T (May 2002). "Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments". J Biol Chem. 277 (22): 20041–50. doi: 10.1074/jbc.M111807200 . PMID   11923287.
6. "Entrez Gene: PI4K2B phosphatidylinositol 4-kinase type 2 beta".

Further reading

• Griffioen M, van der Meijden ED, Slager EH, et al. (2008). "Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3837–42. Bibcode:2008PNAS..105.3837G. doi: 10.1073/pnas.0712250105 . PMC   2268788 . PMID   18316730.
• Jones DR, Bultsma Y, Keune WJ, et al. (2006). "Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta". Mol. Cell. 23 (5): 685–95. doi: 10.1016/j.molcel.2006.07.014 . PMID   16949365.
• Srivastava R, Sinha RK, Subrahmanyam G (2006). "Type II phosphatidylinositol 4-kinase beta associates with TCR-CD3 zeta chain in Jurkat cells". Mol. Immunol. 43 (5): 454–63. doi:10.1016/j.molimm.2005.03.009. PMID   16337488.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wei YJ, Sun HQ, Yamamoto M, et al. (2003). "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP". J. Biol. Chem. 277 (48): 46586–93. doi: 10.1074/jbc.M206860200 . PMID   12324459.
• Mora S, Durham PL, Smith JR, et al. (2002). "NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes through a phosphatidylinositol 4-kinase-dependent pathway". J. Biol. Chem. 277 (30): 27494–500. doi: 10.1074/jbc.M203669200 . hdl: 2445/176737 . PMID   12011096.
• Huang C, Handlogten ME, Miller RT (2002). "Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor". J. Biol. Chem. 277 (23): 20293–300. doi: 10.1074/jbc.M200831200 . PMID   11907035.