PIB5PA

INPP5J
Identifiers
Aliases	INPP5J , INPP5, PIB5PA, PIPP, inositol polyphosphate-5-phosphatase J
External IDs	OMIM: 606481 MGI: 2158663 HomoloGene: 8682 GeneCards: INPP5J
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,134,697 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,504,821 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; parotid gland; ; left ventricle; ; duodenum; ; body of pancreas; ; body of stomach; ; kidney; ; prefrontal cortex; ; cingulate gyrus;
	Top expressed in
	cerebellar cortex; ; submandibular gland; ; superior frontal gyrus; ; entorhinal cortex; ; masseter muscle; ; medulla oblongata; ; olfactory bulb; ; lateral geniculate nucleus; ; left colon; ; inferior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding ; inositol-polyphosphate 5-phosphatase activity ; protein binding ; hydrolase activity ; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity ; inositol-1,4,5-trisphosphate 5-phosphatase activity ; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity ;
Cellular component	cytoplasm ; ruffle ; growth cone ; dendritic shaft ; cytosol ; plasma membrane ;
Biological process	phosphatidylinositol biosynthetic process ; negative regulation of neuron projection development ; inositol phosphate metabolic process ; negative regulation of microtubule polymerization ; phosphatidylinositol dephosphorylation ; negative regulation of peptidyl-serine phosphorylation ; inositol phosphate dephosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	27124
	170835
	ENSG00000185133
	ENSMUSG00000034570
	Q15735
	P59644
NM_001002837 ; NM_001284285 ; NM_001284286 ; NM_001284287 ; NM_001284288 ;
	NM_001284289 ; NM_014422
	NM_172439
NP_001002837 ; NP_001271214 ; NP_001271215 ; NP_001271216 ; NP_001271217 ;
	NP_001271218
	NP_766027
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A is an enzyme that in humans is encoded by the INPP5J gene.^[5]^[6]

Related Research Articles

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1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene.

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 is an enzyme that in humans is encoded by the PLCB4 gene.

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.

Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.

Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene.

Secretory carrier-associated membrane protein 2 is a protein that in humans is encoded by the SCAMP2 gene.

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.

Protein sprouty homolog 3 is a protein that in humans is encoded by the SPRY3 gene.

CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene.

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene. INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.

SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.

72 kDa inositol polyphosphate 5-phosphatase, also known as phosphatidylinositol-4,5-bisphosphate 5-phosphatase or Pharbin, is an enzyme that in humans is encoded by the INPP5E gene.

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.

Inositol polyphosphate-5-phosphatase F is a protein that in humans is encoded by the INPP5F gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185133 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034570 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
↑ "Entrez Gene: PIB5PA phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gurung R, Tan A, Ooms LM, et al. (2003). "Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation". J. Biol. Chem. 278 (13): 11376–85. doi: 10.1074/jbc.M209991200 . PMID 12536145.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mochizuki Y, Takenawa T (2000). "Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles". J. Biol. Chem. 274 (51): 36790–5. doi: 10.1074/jbc.274.51.36790 . PMID 10593988.
Krämer J, Aguirre-Arteta AM, Thiel C, et al. (1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin". J. Mol. Med. 77 (2): 294–8. doi:10.1007/s001090050352. PMID 10023782. S2CID 3017418.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185133 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034570 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.

[entrez-6] "Entrez Gene: PIB5PA phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A".

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PIB5PA

Related Research Articles

References

Further reading