PIK3C2B

PIK3C2B
Identifiers
Aliases	PIK3C2B , C2-PI3K, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
External IDs	OMIM: 602838; MGI: 2685045; HomoloGene: 20582; GeneCards: PIK3C2B; OMA:PIK3C2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 204,422,628 bp [1] End 204,494,805 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 132,973,405 bp [2] End 133,036,425 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell inferior ganglion of vagus nerve gingival epithelium pylorus nipple vena cava ventral tegmental area epithelium of nasopharynx visceral pleura superficial temporal artery Top expressed in zygote secondary oocyte primary oocyte tail of embryo skeletal muscle tissue striatum of neuraxis genital tubercle heart muscle of thigh colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding lipid kinase activity 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity kinase activity protein binding phosphatidylinositol binding ATP binding Cellular component phosphatidylinositol 3-kinase complex membrane intracellular membrane-bounded organelle plasma membrane endocytic vesicle endoplasmic reticulum nucleus nucleoplasm cytosol cytoplasm Biological process protein kinase B signaling phosphorylation phosphatidylinositol phosphate biosynthetic process phosphatidylinositol-mediated signaling cellular response to starvation phosphatidylinositol-3-phosphate biosynthetic process autophagosome organization macroautophagy phosphatidylinositol 3-kinase signaling cell migration biological process phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5287 240752 Ensembl ENSG00000133056 ENSMUSG00000026447 UniProt O00750 n/a RefSeq (mRNA) NM_002646 NM_001377334 NM_001377335 NM_001099276 RefSeq (protein) NP_002637 NP_001364263 NP_001364264 n/a Location (UCSC) Chr 1: 204.42 – 204.49 Mb Chr 1: 132.97 – 133.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not Ca²⁺, which suggests that this enzyme may function in a calcium-independent manner. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000133056 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026447 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (Apr 1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochemical and Biophysical Research Communications. 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID   9144573.
6. Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (Dec 1998). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". The Journal of Biological Chemistry. 273 (49): 33082–90. doi: 10.1074/jbc.273.49.33082 . PMID   9830063.
7. "Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide".

Further reading

• Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (Nov 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID   12960231. S2CID   11362623.
• Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (Oct 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID   8084603.
• Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (Sep 1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". The Journal of Biological Chemistry. 271 (38): 22961–4. doi: 10.1074/jbc.271.38.22961 . PMID   8798481.
• Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (Jun 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi: 10.1038/sj.onc.1201153 . PMID   9223670.
• Mazerolles F, Barbat C, Fischer A (Sep 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID   9341793. S2CID   33397908.
• Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, Capitani S (Nov 1997). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". European Journal of Immunology. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID   9394803. S2CID   6303471.
• Borgatti P, Zauli G, Cantley LC, Capitani S (Jan 1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochemical and Biophysical Research Communications. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID   9446795.
• Milani D, Mazzoni M, Zauli G, Mischiati C, Gibellini D, Giacca M, Capitani S (Jul 1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi: 10.1097/00002030-199811000-00008 . PMID   9708406. S2CID   25758704.
• Jauliac S, Mazerolles F, Jabado N, Pallier A, Bernard F, Peake J, Fischer A, Hivroz C (Oct 1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". European Journal of Immunology. 28 (10): 3183–91. doi: 10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A . PMID   9808187.
• Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J (Jun 2000). "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors". Molecular and Cellular Biology. 20 (11): 3817–30. doi:10.1128/MCB.20.11.3817-3830.2000. PMC   85707 . PMID   10805725.
• Park IW, Wang JF, Groopman JE (Jan 2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. doi: 10.1182/blood.V97.2.352 . PMID   11154208.
• Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (Feb 2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB Journal. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID   11156964. S2CID   26315564.
• Wheeler M, Domin J (Oct 2001). "Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2". Molecular and Cellular Biology. 21 (19): 6660–7. doi:10.1128/MCB.21.19.6660-6667.2001. PMC   99811 . PMID   11533253.
• Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G (Jul 2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". The Journal of Biological Chemistry. 277 (28): 25195–202. doi: 10.1074/jbc.M200921200 . PMID   11994280.
• Cook JA, August A, Henderson AJ (Jul 2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". Journal of Immunology. 169 (1): 254–60. doi: 10.4049/jimmunol.169.1.254 . PMID   12077252.
• Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ (Oct 2002). "Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation". The EMBO Journal. 21 (19): 5097–108. doi:10.1093/emboj/cdf512. PMC   129034 . PMID   12356726.
• Visnjić D, Crljen V, Curić J, Batinić D, Volinia S, Banfić H (Oct 2002). "The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells". FEBS Letters. 529 (2–3): 268–74. doi:10.1016/S0014-5793(02)03357-4. PMID   12372612. S2CID   29067083.