PIK3C3

PIK3C3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IHY, 3LS8, 4OYS, 4PH4, 4UWF, 4UWG, 4UWH, 4UWL, 5ANL
Identifiers
Aliases	PIK3C3 , VPS34, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3
External IDs	OMIM: 602609 MGI: 2445019 HomoloGene: 1986 GeneCards: PIK3C3
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q12.3 Start 41,955,234 bp [1] End 42,087,830 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B1 Start 30,405,800 bp [2] End 30,481,179 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon endothelial cell stromal cell of endometrium ganglionic eminence Brodmann area 23 tibial nerve postcentral gyrus monocyte thymus corpus callosum Top expressed in lesser wing of sphenoid bone occiput occipital bone Meckel's cartilage rib parotid gland epithelium of stomach submandibular gland humerus ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding 1-phosphatidylinositol-3-kinase activity protein binding phosphatidylinositol 3-kinase activity ATP binding kinase activity Cellular component cytosol endosome late endosome phagocytic vesicle membrane membrane phosphatidylinositol 3-kinase complex, class III autophagosome midbody phagocytic vesicle axoneme cytoplasmic vesicle autolysosome phagophore assembly site peroxisome phosphatidylinositol 3-kinase complex, class III, type I phosphatidylinositol 3-kinase complex, class III, type II cytoplasm intracellular anatomical structure Biological process cellular response to glucose starvation regulation of cytokinesis phosphorylation protein processing response to leucine cytokinesis endosome organization cell division phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process early endosome to late endosome transport phosphatidylinositol biosynthetic process cell cycle toll-like receptor 9 signaling pathway macroautophagy regulation of protein secretion protein localization to phagophore assembly site cellular response to starvation protein lipidation autophagy autophagosome assembly protein phosphorylation endocytosis autophagy of peroxisome phosphatidylinositol-mediated signaling interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5289 225326 Ensembl ENSG00000078142 ENSMUSG00000033628 UniProt Q8NEB9 Q6PF93 RefSeq (mRNA) NM_001308020 NM_002647 NM_181414 RefSeq (protein) NP_001294949 NP_002638 NP_852079 Location (UCSC) Chr 18: 41.96 – 42.09 Mb Chr 18: 30.41 – 30.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene. ^{[5] [6]} It's a class III phosphoinositide 3-kinase.

References

1. GRCh38: Ensembl release 89: ENSG00000078142 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033628 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD (Sep 1995). "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system". EMBO J. 14 (14): 3339–48. doi:10.1002/j.1460-2075.1995.tb07340.x. PMC   394401 . PMID   7628435.
6. "Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3".

Further reading

• Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi: 10.1189/jlb.0503206 . PMID   12960231. S2CID   11362623.
• Vogel LB, Fujita DJ (1994). "The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes". Mol. Cell. Biol. 13 (12): 7408–17. doi:10.1128/mcb.13.12.7408. PMC   364812 . PMID   7504174.
• Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. doi: 10.1074/jbc.271.38.22961 . PMID   8798481.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Panaretou C, Domin J, Cockcroft S, Waterfield MD (1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): 2477–85. doi: 10.1074/jbc.272.4.2477 . PMID   8999962.
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID   9341793. S2CID   33397908.
• Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID   9394803. S2CID   6303471.
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID   9446795.
• Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi: 10.1097/00002030-199811000-00008 . PMID   9708406. S2CID   25758704.
• Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. doi: 10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A . PMID   9808187.
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. doi: 10.1182/blood.V97.2.352 . PMID   11154208.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID   11156964. S2CID   26315564.
• Deregibus MC, Cantaluppi V, Doublier S, et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". J. Biol. Chem. 277 (28): 25195–202. doi: 10.1074/jbc.M200921200 . PMID   11994280.
• Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". J. Immunol. 169 (1): 254–60. doi: 10.4049/jimmunol.169.1.254 . PMID   12077252.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages". J. Virol. 77 (4): 2539–49. doi:10.1128/JVI.77.4.2539-2549.2003. PMC   141101 . PMID   12551992.
• Vergne I, Chua J, Deretic V (2003). "Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade". J. Exp. Med. 198 (4): 653–9. doi:10.1084/jem.20030527. PMC   2194170 . PMID   12925680.
• Khan NA, Di Cello F, Nath A, Kim KS (2004). "Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells". J. Neurovirol. 9 (6): 584–93. doi:10.1080/jnv.9.6.584.593. PMID   14602571.