PIK3CB

Last updated
PIK3CB
Identifiers
Aliases PIK3CB , P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
External IDs OMIM: 602925 MGI: 1922019 HomoloGene: 21250 GeneCards: PIK3CB
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256045
NM_006219

NM_029094

RefSeq (protein)

NP_001242974
NP_006210

NP_083370

Location (UCSC) Chr 3: 138.65 – 138.83 Mb Chr 9: 98.92 – 99.02 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene. [5] [6]

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM] [6]

Related Research Articles

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<span class="mw-page-title-main">PIK3R1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PIK3R2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PLCG2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PRKCH</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PLCB1</span> Protein-coding gene in the species Homo sapiens

1-Phosphatidylinositol-4,5-bisphosphate phospholipase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.

<span class="mw-page-title-main">PLCB2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PRKD3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PRKACB</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PLCB3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PIK3C2A</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PIK3C2B</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.

<span class="mw-page-title-main">PLCD4</span> Protein-coding gene in the species Homo sapiens

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 is an enzyme that in humans is encoded by the PLCD4 gene.

<span class="mw-page-title-main">PLCB4</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PIK3C2G</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.

<span class="mw-page-title-main">PIK3R5</span> Protein-coding gene in the species Homo sapiens

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000051382 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032462 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hu P, Mondino A, Skolnik EY, Schlessinger J (Jan 1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol Cell Biol. 13 (12): 7677–88. doi:10.1128/mcb.13.12.7677. PMC   364839 . PMID   8246984.
  6. 1 2 "Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide".

Further reading