PIK3CB

PIK3CB
Identifiers
Aliases	PIK3CB , P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
External IDs	OMIM: 602925 MGI: 1922019 HomoloGene: 21250 GeneCards: PIK3CB
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q22.3 Start 138,652,698 bp [1] End 138,834,928 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E3.3 Start 98,918,707 bp [2] End 99,022,674 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus endothelial cell middle temporal gyrus Brodmann area 23 kidney tubule optic nerve pons jejunal mucosa postcentral gyrus superior frontal gyrus Top expressed in superior cervical ganglion esophagus interventricular septum facial motor nucleus morula secondary oocyte lip spermatocyte conjunctival fornix yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding 1-phosphatidylinositol-4-phosphate 3-kinase activity protein binding insulin receptor substrate binding ATP binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity kinase activity 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity phosphatidylinositol-3,4-bisphosphate 5-kinase activity Cellular component cytosol phosphatidylinositol 3-kinase complex plasma membrane nucleolus nucleus midbody cytoplasm membrane intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway embryonic cleavage endocytosis positive regulation of autophagy Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway angiogenesis involved in wound healing cellular calcium ion homeostasis regulation of cell-matrix adhesion platelet activation autophagy Fc-epsilon receptor signaling pathway chemotaxis phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process positive regulation of gene expression vascular endothelial growth factor receptor signaling pathway cell adhesion response to wounding endothelial cell proliferation regulation of clathrin-dependent endocytosis T cell receptor signaling pathway platelet aggregation cell migration phosphatidylinositol-mediated signaling leukocyte migration signal transduction homophilic cell adhesion via plasma membrane adhesion molecules axon guidance phosphorylation adaptive immune response inflammatory response positive regulation of neutrophil apoptotic process innate immune response cell chemotaxis positive regulation of protein kinase B signaling phosphatidylinositol 3-kinase signaling cytokine-mediated signaling pathway protein phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5291 74769 Ensembl ENSG00000051382 ENSMUSG00000032462 UniProt P42338 Q8BTI9 RefSeq (mRNA) NM_001256045 NM_006219 NM_029094 RefSeq (protein) NP_001242974 NP_006210 NP_083370 Location (UCSC) Chr 3: 138.65 – 138.83 Mb Chr 9: 98.92 – 99.02 Mb PubMed search [3] [4]
Wikidata
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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene. ^{[5] [6]}

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000051382 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032462 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hu P, Mondino A, Skolnik EY, Schlessinger J (Jan 1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol Cell Biol. 13 (12): 7677–88. doi:10.1128/mcb.13.12.7677. PMC   364839 . PMID   8246984.
6. "Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide".

Further reading

• Katada T, Kurosu H, Okada T, et al. (1999). "Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors". Chem. Phys. Lipids. 98 (1–2): 79–86. doi:10.1016/S0009-3084(99)00020-1. PMID   10358930.
• Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID   12960231. S2CID   11362623.
• Carpenter CL, Duckworth BC, Auger KR, et al. (1991). "Purification and characterization of phosphoinositide 3-kinase from rat liver". J. Biol. Chem. 265 (32): 19704–11. doi: 10.1016/S0021-9258(17)45429-9 . PMID   2174051.
• Bonnefoy-Bérard N, Liu YC, von Willebrand M, et al. (1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10142–6. Bibcode:1995PNAS...9210142B. doi: 10.1073/pnas.92.22.10142 . PMC   40752 . PMID   7479742.
• Hu P, Schlessinger J (1994). "Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta". Mol. Cell. Biol. 14 (4): 2577–83. doi:10.1128/mcb.14.4.2577. PMC   358625 . PMID   8139559.
• Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. doi: 10.1074/jbc.271.38.22961 . PMID   8798481.
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID   9341793. S2CID   33397908.
• Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID   9394803. S2CID   6303471.
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID   9446795.
• Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi: 10.1097/00002030-199811000-00008 . PMID   9708406. S2CID   25758704.
• Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. doi: 10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A . PMID   9808187.
• Graness A, Adomeit A, Heinze R, et al. (1998). "A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon". J. Biol. Chem. 273 (48): 32016–22. doi: 10.1074/jbc.273.48.32016 . PMID   9822674.
• Sotsios Y, Whittaker GC, Westwick J, Ward SG (1999). "The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes". J. Immunol. 163 (11): 5954–63. doi: 10.4049/jimmunol.163.11.5954 . PMID   10570282.
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. doi: 10.1182/blood.V97.2.352 . PMID   11154208.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID   11156964. S2CID   26315564.
• Yang H, Wang X, Raizada MK (2001). "Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons". Endocrinology. 142 (8): 3502–11. doi: 10.1210/en.142.8.3502 . PMID   11459796.
• Steták A, Csermely P, Ullrich A, Kéri G (2001). "Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta". Biochem. Biophys. Res. Commun. 288 (3): 564–72. doi:10.1006/bbrc.2001.5811. PMID   11676480.
• Ueki K, Yballe CM, Brachmann SM, et al. (2002). "Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 419–24. Bibcode:2002PNAS...99..419U. doi: 10.1073/pnas.012581799 . PMC   117575 . PMID   11752399.