PIP5K1A

Last updated
PIP5K1A
Identifiers
Aliases PIP5K1A , phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
External IDs OMIM: 603275 MGI: 107929 HomoloGene: 93492 GeneCards: PIP5K1A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135636
NM_001135637
NM_001135638
NM_003557
NM_001330689

NM_001293707
NM_008847

RefSeq (protein)

NP_001129108
NP_001129109
NP_001129110
NP_001317618
NP_003548

NP_001280636
NP_032873

Location (UCSC) Chr 1: 151.2 – 151.25 Mb Chr 3: 95.06 – 95.11 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene. [5] [6] [7]


Related Research Articles

<span class="mw-page-title-main">Phosphatidylinositol 4,5-bisphosphate</span> Chemical compound

Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid component of cell membranes. PtdIns(4,5)P2 is enriched at the plasma membrane where it is a substrate for a number of important signaling proteins.

<span class="mw-page-title-main">Lipid signaling</span>

Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms because lipids can freely diffuse through membranes. One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized "on demand" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum.

<span class="mw-page-title-main">Ezrin</span> Protein-coding gene in the species Homo sapiens

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.

<span class="mw-page-title-main">PLD2</span> Protein-coding gene in the species Homo sapiens

Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.

<span class="mw-page-title-main">PLCB1</span>

1-Phosphatidylinositol-4,5-bisphosphate phospholipase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.

<span class="mw-page-title-main">PIK3CB</span>

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.

<span class="mw-page-title-main">PLCB2</span>

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.

<span class="mw-page-title-main">PIK3C2A</span>

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the PIK3C2A gene.

<span class="mw-page-title-main">PIK3C3</span>

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene. It's a class III phosphoinositide 3-kinase.

<span class="mw-page-title-main">PI4KA</span>

Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene.

<span class="mw-page-title-main">DGKZ</span>

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.

<span class="mw-page-title-main">PIP5K1C</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma is an enzyme that in humans is encoded by the PIP5K1C gene.

<span class="mw-page-title-main">PIP4K2A</span> Kinase enzyme

Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha is an enzyme that in humans is encoded by the PIP4K2A gene.

<span class="mw-page-title-main">INPP4A</span>

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.

<span class="mw-page-title-main">PIK3C2G</span>

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.

<span class="mw-page-title-main">PI4K2A</span>

Phosphatidylinositol 4-kinase 2-alpha is an enzyme that in humans is encoded by the PI4K2A gene.

<span class="mw-page-title-main">PIP4K2B</span>

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.

<span class="mw-page-title-main">PIP5K1B</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol-4-phosphate 5-kinase type-1 beta is an enzyme that in humans is encoded by the PIP5K1B gene.

<span class="mw-page-title-main">PI4K2B</span>

Phosphatidylinositol 4-kinase type 2-beta is an enzyme that in humans is encoded by the PI4K2B gene.

Phosphatidylinositol-4-phosphate 5-kinases are a class of enzymes that phosphorylate phosphatidylinositol 4-phosphate. They perform this reaction on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol 4,5-bisphosphate.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143398 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028126 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Loijens JC, Anderson RA (Jan 1997). "Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family". J Biol Chem. 271 (51): 32937–43. doi: 10.1074/jbc.271.51.32937 . PMID   8955136.
  6. Xie Y, Zhu L, Zhao G (Jun 2000). "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization". Cytogenet Cell Genet. 88 (3–4): 197–9. doi:10.1159/000015545. PMID   10828584. S2CID   45527362.
  7. "Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha".

Further reading