PISD (gene)

PISD
Identifiers
Aliases	PISD , DJ858B16, PSD, PSDC, PSSC, dJ858B16.2, phosphatidylserine decarboxylase, LIBF
External IDs	OMIM: 612770; MGI: 2445114; HomoloGene: 81653; GeneCards: PISD; OMA:PISD - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q12.2 Start 31,618,491 bp [1] End 31,662,221 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B1 Start 32,893,645 bp [2] End 32,942,990 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum paraflocculus of cerebellum cerebellar vermis granulocyte blood monocyte right frontal lobe spleen pituitary gland Top expressed in hypothalamus proximal tubule granulocyte colon right kidney mesencephalon duodenum neural tube jejunum spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carboxy-lyase activity lyase activity phosphatidylserine decarboxylase activity Cellular component integral component of membrane mitochondrial inner membrane membrane mitochondrion nucleus integral component of mitochondrial inner membrane Biological process lipid metabolism phospholipid biosynthetic process phosphatidylethanolamine biosynthetic process protein autoprocessing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23761 320951 Ensembl ENSG00000241878 ENSMUSG00000023452 UniProt Q9UG56 Q8BSF4 RefSeq (mRNA) NM_014338 NM_001326411 NM_001326412 NM_001326413 NM_001326414 NM_001326415 NM_001326416 NM_001326417 NM_001326418 NM_001326419 NM_001326420 NM_001326421 NM_178022 NM_177298 NM_001347332 RefSeq (protein) NP_001313340 NP_001313341 NP_001313342 NP_001313343 NP_001313344 NP_001313345 NP_001313346 NP_001313347 NP_001313348 NP_001313349 NP_001313350 NP_055153 NP_821141 NP_001334261 NP_796272 Location (UCSC) Chr 22: 31.62 – 31.66 Mb Chr 5: 32.89 – 32.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylserine decarboxylase proenzyme is an enzyme that in humans is encoded by the PISD gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000241878 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023452 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22" (PDF). Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
6. "Entrez Gene: PISD phosphatidylserine decarboxylase".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Kuge O, Saito K, Kojima M, Akamatsu Y, Nishijima M (1996). "Post-translational processing of the phosphatidylserine decarboxylase gene product in Chinese hamster ovary cells". Biochem. J. 319 ( Pt 1) (Pt 1): 33–8. doi:10.1042/bj3190033. PMC   1217732 . PMID   8870646.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID   15790807. S2CID   13047538.
• Steenbergen R, Nanowski TS, Beigneux A, Kulinski A, Young SG, Vance JE (2006). "Disruption of the Phosphatidylserine Decarboxylase Gene in Mice Causes Embryonic Lethality and Mitochondrial Defects". J. Biol. Chem. 280 (48): 40032–40. doi: 10.1074/jbc.M506510200 . PMC   2888304 . PMID   16192276.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Forbes CD, Toth JG, Ozbal CC, Lamarr WA, Pendleton JA, Rocks S, Gedrich RW, Osterman DG, Landro JA, Lumb KJ (2007). "High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase". Journal of Biomolecular Screening. 12 (5): 628–34. doi: 10.1177/1087057107301320 . PMID   17478478.