PISD (gene)

PISD
Identifiers
Aliases	PISD , DJ858B16, PSD, PSDC, PSSC, dJ858B16.2, phosphatidylserine decarboxylase, LIBF
External IDs	OMIM: 612770 MGI: 2445114 HomoloGene: 81653 GeneCards: PISD
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,662,221 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	32,942,990 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; cerebellar vermis; ; blood; ; monocyte; ; spleen; ; pituitary gland; ; left adrenal gland; ; anterior pituitary; ; left uterine tube; ; upper lobe of left lung;
	Top expressed in
	hypothalamus; ; proximal tubule; ; colon; ; mesencephalon; ; duodenum; ; neural tube; ; jejunum; ; spermatocyte; ; placenta; ; basal forebrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxy-lyase activity ; lyase activity ; phosphatidylserine decarboxylase activity ;
Cellular component	integral component of membrane ; mitochondrial inner membrane ; membrane ; mitochondrion ; nucleus ; integral component of mitochondrial inner membrane ;
Biological process	lipid metabolism ; phospholipid biosynthetic process ; phosphatidylethanolamine biosynthetic process ; protein autoprocessing ;
	Sources:Amigo / QuickGO
Orthologs
	23761
	320951
	ENSG00000241878
	ENSMUSG00000023452
	Q9UG56
	Q8BSF4
NM_014338 ; NM_001326411 ; NM_001326412 ; NM_001326413 ; NM_001326414 ;
	NM_001326415 ; NM_001326416 ; NM_001326417 ; NM_001326418 ; NM_001326419 ; NM_001326420 ; NM_001326421 ; NM_178022
	NM_177298 ; NM_001347332
NP_001313340 ; NP_001313341 ; NP_001313342 ; NP_001313343 ; NP_001313344 ;
	NP_001313345 ; NP_001313346 ; NP_001313347 ; NP_001313348 ; NP_001313349 ; NP_001313350 ; NP_055153 ; NP_821141
	NP_001334261 ; NP_796272
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Phosphatidylserine decarboxylase proenzyme is an enzyme that in humans is encoded by the PISD gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000241878 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023452 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
↑ "Entrez Gene: PISD phosphatidylserine decarboxylase".

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Kuge O, Saito K, Kojima M, Akamatsu Y, Nishijima M (1996). "Post-translational processing of the phosphatidylserine decarboxylase gene product in Chinese hamster ovary cells". Biochem. J. 319 ( Pt 1) (Pt 1): 33–8. doi:10.1042/bj3190033. PMC 1217732 . PMID 8870646.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Steenbergen R, Nanowski TS, Beigneux A, Kulinski A, Young SG, Vance JE (2006). "Disruption of the Phosphatidylserine Decarboxylase Gene in Mice Causes Embryonic Lethality and Mitochondrial Defects". J. Biol. Chem. 280 (48): 40032–40. doi: 10.1074/jbc.M506510200 . PMC 2888304 . PMID 16192276.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Forbes CD, Toth JG, Ozbal CC, Lamarr WA, Pendleton JA, Rocks S, Gedrich RW, Osterman DG, Landro JA, Lumb KJ (2007). "High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase". Journal of Biomolecular Screening. 12 (5): 628–34. doi: 10.1177/1087057107301320 . PMID 17478478.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000241878 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023452 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.

[entrez-6] "Entrez Gene: PISD phosphatidylserine decarboxylase".

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PISD (gene)

Related Research Articles

References

Further reading